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1.
MethodsX ; 12: 102507, 2024 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-38204979

RESUMO

This study aims to automatically analyze and extract abnormalities in the lung field due to Coronavirus Disease 2019 (COVID-19). Types of abnormalities that can be detected are Ground Glass Opacity (GGO) and consolidation. The proposed method can also identify the location of the abnormality in the lung field, that is, the central and peripheral lung area. The location and type of these abnormalities affect the severity and confidence level of a patient suffering from COVID-19. The detection results using the proposed method are compared with the results of manual detection by radiologists. From the experimental results, the proposed system can provide an average error of 0.059 for the severity score and 0.069 for the confidence level. This method has been implemented in a web-based application for general users.•A method to detect the appearance of viral pneumonia imaging features, namely Ground Glass Opacity (GGO) and consolidation on the chest Computed Tomography (CT) scan images.•This method can separate the lung field to the right lung and the left lung, and it also can identify the detected imaging feature's location in the central or peripheral of the lung field.•Severity level and confidence level of the patient's suffering are measured.

2.
Comput Biol Med ; 163: 107241, 2023 09.
Artigo em Inglês | MEDLINE | ID: mdl-37437362

RESUMO

Predicting DNA-binding proteins (DBPs) based solely on primary sequences is one of the most challenging problems in genome annotation. DBPs play a crucial role in various biological processes, including DNA replication, transcription, repair, and splicing. Some DBPs are essential in pharmaceutical research on various human cancers and autoimmune diseases. Existing experimental methods for identifying DBPs are time-consuming and costly. Therefore, developing a rapid and accurate computational technique is necessary to address the issue. This study introduces BiCaps-DBP, a deep learning-based method that improves DBP prediction performance by combining bidirectional long short-term memory with a 1D-capsule network. This study uses three training and independent datasets to evaluate the proposed model's generalizability and robustness. Based on three independent datasets, BiCaps-DBP achieved 1.05%, 5.79% and 0.40% higher accuracies than an existing predictor for PDB2272, PDB186 and PDB20000, respectively. These outcomes indicate that the proposed method is a promising DBP predictor.


Assuntos
Proteínas de Ligação a DNA , Genoma , Humanos , Proteínas de Ligação a DNA/genética , Proteínas de Ligação a DNA/metabolismo , Sequência de Aminoácidos
3.
Comput Methods Programs Biomed ; 209: 106302, 2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-34390937

RESUMO

BACKGROUND AND OBJECTIVE: Object detection is a primary research interest in computer vision. Sperm-cell detection in a densely populated bull semen microscopic observation video presents challenges that are more difficult than those presented by other general object-detection cases. These challenges include partial occlusion, vast number of objects in a single video frame, tiny size of the object, artifacts, low contrast, low video resolution, and blurry objects because of the rapid movement of the sperm cells. This study proposes a deep neural network architecture, called DeepSperm, that solves the aforementioned problems and is more accurate and faster than state-of-the-art architectures. METHODS: In the proposed architecture, we use only one detection layer, which is specific for small object detection. For handling overfitting and increasing accuracy, we set a higher input network resolution, use a dropout layer, and perform data augmentation on saturation and exposure. Several hyper-parameters are tuned to achieve better performance. Mean average precision (mAP), confusion matrix, precision, recall, and F1-score are used to measure accuracy. Frame per second (fps) is used to measure speed. We compare our proposed method with you only look once (YOLO) v3 and YOLOv4. RESULTS: In our experiment, we achieve 94.11 mAP on the test dataset, F1-score of 0.93, and a processing speed of 51.9 fps. In comparison with YOLOv4, our proposed method is 2.18 x faster on testing, and 2.9 x faster on training with a small dataset, while achieving comparative detection accuracy. The weights file size was also reduced significantly, with one-twentieth that of YOLOv4. Moreover, it requires a 1.07 x less graphical processing unit (GPU) memory than YOLOv4. CONCLUSIONS: This study proposes DeepSperm, which is a simple, effective, and efficient deep neural network architecture with its hyper-parameters and configuration to detect bull sperm cells robustly in real time. In our experiments, we surpass the state-of-the-art in terms of accuracy, speed, and resource needs.


Assuntos
Redes Neurais de Computação , Sêmen , Animais , Bovinos , Masculino , Espermatozoides
4.
Minerva Cardioangiol ; 48(12 Suppl 1): 53-6, 2000 Dec.
Artigo em Italiano | MEDLINE | ID: mdl-11253341

RESUMO

The need of prolonged bed-rest for the treatment of Deep Venous Thrombosis (DVT), which was considered essential to control the thrombotic phenomenon and to prevent Pulmonary Embolism (PE) until ten years ago, has now been critically reviewed in the light of the great success of the Low Molecular Weight Heparin (LMWH) in medical therapy of DVT. There is a great evidence for bed-rest and immobility to play a pivotal role in the growth and in the progression of a venous thrombosis. The Authors emphasize, both on the international reports and their own experience, that, in most cases, medical treatment of DVT consists of an outpatient--ambulatory care based on immediate mobilization and ambulation, on external compression therapy, on early LMWH administration and late oral anticoagulation. This regimen provides great benefits in order to prevent PE, to improve the quality of life, to reduce the hospital and the anticoagulant monitoring charges.


Assuntos
Anticoagulantes/uso terapêutico , Repouso em Cama , Deambulação Precoce , Fibrinolíticos/uso terapêutico , Heparina de Baixo Peso Molecular/uso terapêutico , Trombose Venosa/terapia , Doença Aguda , Administração Oral , Anticoagulantes/administração & dosagem , Ensaios Clínicos como Assunto , Fibrinolíticos/administração & dosagem , Seguimentos , Heparina de Baixo Peso Molecular/administração & dosagem , Humanos , Embolia Pulmonar/prevenção & controle , Ensaios Clínicos Controlados Aleatórios como Assunto , Fatores de Risco , Fatores de Tempo , Trombose Venosa/complicações , Trombose Venosa/tratamento farmacológico
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