[Sensitivity to combined metronidazole and penicillin in 227 strains of non-sporulated anaerobic bacteria]. / Sensibilitatea la combinatia metronidazol-penicilina a 227 de tulpini de germeni anaerobi nesporulati.

Combined metronidazol-penicillin, used in large amounts corresponding to the selective concentrations in vitro of 25 + 25 IU, may be assumed to be effective in all clinical infections in which one or several anaerobes are implicated. The experiments carried out demonstrate that this is valid for all categories of Grampositive or Gramnegative non-sporulate anaerobes. The antibiotic concentrations used are well tolerated by the human organism.

[Study of Coxsackie A 10 virus infection in newborn and suckling mice of the strains A2G, ICR-K and CBA]. / Studiu asupra infectiei cu virus Coxsackie A10 a soarecilor de prima vîrsta din tulpinile A2G, ICR-K si CBA.

Differences in the susceptibility to paralytogenic infection with Coxsackie A10 virus were found in neonate and suckling mice belonging to A2G, ICR-K and CBA strains and ICR-K/CBA and CBA/ICR-K hybrids in the F1 generation. At the first passage in vivo the more susceptible strains selected paralytogenic viral particles from among the cytopathogenic and non-pathogenic Coxsackie A10 virus populations. The differences in susceptibility could not be related either with the humoral immune response to virus or to the rate of fixation of virus on the neonate mouse muscle cell receptors. These differences are, however, in agreement with the data concerning the synthesis of interferon in the striated muscle, the lots with greater resistance to viral infection being also those which synthesize interferon in higher concentrations. The hybrids resulting from the parental strains more susceptible to virus, presented a resistance superior to that of the parents.

Influenza hemagglutination-inhibiting antibodies in hospitalized children. Distribution of specific activity into IgM, IgG and IgA classes.

Sera from 75 children hospitalized with a clinical diagnosis of acute respiratory virus disease were tested by hemagglutination-inhibition as regards influenza A2 and B antibody shifts. In 48 patients there was an antibody shift during the clinical evolution of the disease (against influenza A2 in 34, B-- in 11, A2 and B in 3cases). A significant proportion of sera with antibody shift associated with a decrease of serum IgG levels and with an increase of serum IgM and IgA levels.

[Sensitivity to chemotherapeutic agents of bacteria isolated from generalized infections]. / Observatii privind sensibilitatea la chimioterapice a germenilor izolati din infectii generalizate.

A study carried out on 206 bacteriemia infections showed that: the following bacterial flora was implicated in the etiology of bacteremia infections: Staphylococcus aureus in 28.6% of cases, Staphylococcus albus in 20.4% Enterobacteriaceae in 25.7% and Pseudomonas in 3.8%; an increase existed in the number of generalized infections caused by opportunists belonging to the Enterobacteriaceae family and Pseudomonas genus. Similarly, an increase in the resistance to the recently introduced antibiotics, Septrin and Gentamycin, was noted. These observation require antibiotic lebel control and, if it is necessary the association of two or more antibiotics in severe infections.

[Cellular mediated immunity in virus infections]. / Unele aspecte ale imunitatii mediate celular în infectiile cu virusuri.

The intervention of cellular immunity in the course of specific antiviral defence is suggested or confirmed by a series of clinical and experimental findings, i.e. the evolution of certain viral diseases following a second contact with viral antigens; discrepancy between the level of antiviral serum antibodies and the clinical course of some viral diseases; pathohistological alterations in some viral diseases, suggesting the intervention of cellular immunity; the clinical aspects of natural or experimental viral diseases in primary and secondary immunodeficiency. Investigations were likewise carried out on certain indices of cellular immunity in human or experimental viral diseases, such as delayed hypersensitivity skin tests; the transfer of immune lymphocytes; lymphocytic blastic transformation; inhibition of macrophage migration; specific cytotoxicity test. The problems concerning the role of cellular immunity in the specific defence against viruses may be grouped as follows: mechanisms of induction of the immune cellular response in viral infections; relationship between cellular and humoral immunity in antiviral resistance; relative independance of systemic and local cellular immunity in the course of viral diseases; the cellular basis of cellular mediated immunity in viral diseases.