RESUMO
Neutral and cationic tripyridylporphyrin-D-galactose conjugates were synthesized and their antiviral activity against herpes simplex virus type 1 (HSV-1) was evaluated. At non-cytotoxic concentrations the studied compounds show significant antiviral activity after photoactivation. The influence of photoactivation on drug treated cells was also analyzed, at different times of infection with HSV-1, for a neutral (1b) and a cationic glycoporphyrin (3b) derivative. The results show that the inhibition of the viral yield is more dependent on photoactivation for compound 1b than for compound 3b. These two compounds also differ in the inhibitory effect during the viral replicative cycle: while compound 3b inhibits the viral yield at all the addition times assayed, compound 1b is more efficient in later times of infection.
Assuntos
Galactose/química , Galactose/farmacologia , Herpesvirus Humano 1/efeitos dos fármacos , Fármacos Fotossensibilizantes/síntese química , Fármacos Fotossensibilizantes/farmacologia , Porfirinas/química , Piridinas/química , Animais , Antivirais/síntese química , Antivirais/química , Antivirais/farmacologia , Cátions/síntese química , Cátions/química , Sobrevivência Celular/efeitos dos fármacos , Sobrevivência Celular/efeitos da radiação , Chlorocebus aethiops , Galactose/síntese química , Herpesvirus Humano 1/fisiologia , Herpesvirus Humano 1/efeitos da radiação , Estrutura Molecular , Fármacos Fotossensibilizantes/química , Oxigênio Singlete/química , Eletricidade Estática , Relação Estrutura-Atividade , Fatores de Tempo , Células VeroRESUMO
An easy route to cationic beta-vinyl substituted meso-tetraphenylporphyrin derivatives is described. Two novel compounds were tested in vitro for their antiviral photoactivity against herpes simplex virus type 1. One of these compounds exhibited a significant activity, reaching 99% of virus inactivation after 15 min of photoactivation.
