Early-Stage Alzheimer's Disease Prediction Using Machine Learning Models.

Alzheimer's disease (AD) is the leading cause of dementia in older adults. There is currently a lot of interest in applying machine learning to find out metabolic diseases like Alzheimer's and Diabetes that affect a large population of people around the world. Their incidence rates are increasing at an alarming rate every year. In Alzheimer's disease, the brain is affected by neurodegenerative changes. As our aging population increases, more and more individuals, their families, and healthcare will experience diseases that affect memory and functioning. These effects will be profound on the social, financial, and economic fronts. In its early stages, Alzheimer's disease is hard to predict. A treatment given at an early stage of AD is more effective, and it causes fewer minor damage than a treatment done at a later stage. Several techniques such as Decision Tree, Random Forest, Support Vector Machine, Gradient Boosting, and Voting classifiers have been employed to identify the best parameters for Alzheimer's disease prediction. Predictions of Alzheimer's disease are based on Open Access Series of Imaging Studies (OASIS) data, and performance is measured with parameters like Precision, Recall, Accuracy, and F1-score for ML models. The proposed classification scheme can be used by clinicians to make diagnoses of these diseases. It is highly beneficial to lower annual mortality rates of Alzheimer's disease in early diagnosis with these ML algorithms. The proposed work shows better results with the best validation average accuracy of 83% on the test data of AD. This test accuracy score is significantly higher in comparison with existing works.

Quantitative Features Analysis of Water Carrying Nanoparticles of Alumina over a Uniform Surface.

Little is known about the rising impacts of Coriolis force and volume fraction of nanoparticles in industrial, mechanical, and biological domains, with an emphasis on water conveying 47 nm nanoparticles of alumina nanoparticles. We explored the impact of the volume fraction and rotation parameter on water conveying 47 nm of alumina nanoparticles across a uniform surface in this study. The Levenberg-Marquardt backpropagated neural network (LMB-NN) architecture was used to examine the transport phenomena of 47 nm conveying nanoparticles. The partial differential equations (PDEs) are converted into a system of Ordinary Differential Equations (ODEs). To assess our soft-computing process, we used the RK4 method to acquire reference solutions. The problem is investigated using two situations, each with three sub-cases for the change of the rotation parameter K and the volume fraction ϕ. Our simulation results are compared to the reference solutions. It has been proven that our technique is superior to the current state-of-the-art. For further explanation, error histograms, regression graphs, and fitness values are graphically displayed.

Analysis of Nanofluid Particles in a Duct with Thermal Radiation by Using an Efficient Metaheuristic-Driven Approach.

This study investigated the steady two-phase flow of a nanofluid in a permeable duct with thermal radiation, a magnetic field, and external forces. The basic continuity and momentum equations were considered along with the Buongiorno model to formulate the governing mathematical model of the problem. Furthermore, the intelligent computational strength of artificial neural networks (ANNs) was utilized to construct the approximate solution for the problem. The unsupervised objective functions of the governing equations in terms of mean square error were optimized by hybridizing the global search ability of an arithmetic optimization algorithm (AOA) with the local search capability of an interior point algorithm (IPA). The proposed ANN-AOA-IPA technique was implemented to study the effect of variations in the thermophoretic parameter (Nt), Hartmann number (Ha), Brownian (Nb) and radiation (Rd) motion parameters, Eckert number (Ec), Reynolds number (Re) and Schmidt number (Sc) on the velocity profile, thermal profile, Nusselt number and skin friction coefficient of the nanofluid. The results obtained by the designed metaheuristic algorithm were compared with the numerical solutions obtained by the Runge-Kutta method of order 4 (RK-4) and machine learning algorithms based on a nonlinear autoregressive network with exogenous inputs (NARX) and backpropagated Levenberg-Marquardt algorithm. The mean percentage errors in approximate solutions obtained by ANN-AOA-IPA are around 10-6 to 10-7. The graphical analysis illustrates that the velocity, temperature, and concentration profiles of the nanofluid increase with an increase in the suction parameter, Eckert number and Schmidt number, respectively. Solutions and the results of performance indicators such as mean absolute deviation, Theil's inequality coefficient and error in Nash-Sutcliffe efficiency further validate the proposed algorithm's utility and efficiency.

Study of Rolling Motion of Ships in Random Beam Seas with Nonlinear Restoring Moment and Damping Effects Using Neuroevolutionary Technique.

In this paper, a mathematical model for the rolling motion of ships in random beam seas has been investigated. The ships' steady-state rolling motion with a nonlinear restoring moment and damping effect is modeled by the nonlinear second-order differential equation. Furthermore, an artificial neural network (NN)-based, backpropagated Levenberg-Marquardt (LM) algorithm is utilized to interpret a numerical solution for the roll angle (x(t)), velocity (x'(t)), and acceleration (x''(t)) of the ship in random beam seas. A reference data set based on numerical examples of the mathematical model for a rolling ship for the LM-NN algorithm is generated by the numerical solver Runge-Kutta method of order 4 (RK-4). The LM-NN algorithm further uses the created data set for the validation, testing, and training of approximate solutions. The outcomes of the design paradigm are compared with those of the homotopy perturbation method (HPM), optimal homotopy analysis method (OHAM), and RK-4. Statistical analyses of the mean square error (MSE), regression, error histograms, proportional performance, and computational complexity further validate the worth of the LM-NN algorithm.

An Optimistic Solver for the Mathematical Model of the Flow of Johnson Segalman Fluid on the Surface of an Infinitely Long Vertical Cylinder.

In this paper, a novel soft computing technique is designed to analyze the mathematical model of the steady thin film flow of Johnson-Segalman fluid on the surface of an infinitely long vertical cylinder used in the drainage system by using artificial neural networks (ANNs). The approximate series solutions are constructed by Legendre polynomials and a Legendre polynomial-based artificial neural networks architecture (LNN) to approximate solutions for drainage problems. The training of designed neurons in an LNN structure is carried out by a hybridizing generalized normal distribution optimization (GNDO) algorithm and sequential quadratic programming (SQP). To investigate the capabilities of the proposed LNN-GNDO-SQP algorithm, the effect of variations in various non-Newtonian parameters like Stokes number (St), Weissenberg number (We), slip parameters (a), and the ratio of viscosities (ϕ) on velocity profiles of the of steady thin film flow of non-Newtonian Johnson-Segalman fluid are investigated. The results establish that the velocity profile is directly affected by increasing Stokes and Weissenberg numbers while the ratio of viscosities and slip parameter inversely affects the fluid's velocity profile. To validate the proposed technique's efficiency, solutions and absolute errors are compared with reference solutions calculated by RK-4 (ode45) and the Genetic algorithm-Active set algorithm (GA-ASA). To study the stability, efficiency and accuracy of the LNN-GNDO-SQP algorithm, extensive graphical and statistical analyses are conducted based on absolute errors, mean, median, standard deviation, mean absolute deviation, Theil's inequality coefficient (TIC), and error in Nash Sutcliffe efficiency (ENSE). Statistics of the performance indicators are approaching zero, which dictates the proposed algorithm's worth and reliability.

Falkner-Skan Flow with Stream-Wise Pressure Gradient and Transfer of Mass over a Dynamic Wall.

In this work, an important model in fluid dynamics is analyzed by a new hybrid neurocomputing algorithm. We have considered the Falkner-Skan (FS) with the stream-wise pressure gradient transfer of mass over a dynamic wall. To analyze the boundary flow of the FS model, we have utilized the global search characteristic of a recently developed heuristic, the Sine Cosine Algorithm (SCA), and the local search characteristic of Sequential Quadratic Programming (SQP). Artificial neural network (ANN) architecture is utilized to construct a series solution of the mathematical model. We have called our technique the ANN-SCA-SQP algorithm. The dynamic of the FS system is observed by varying stream-wise pressure gradient mass transfer and dynamic wall. To validate the effectiveness of ANN-SCA-SQP algorithm, our solutions are compared with state-of-the-art reference solutions. We have repeated a hundred experiments to establish the robustness of our approach. Our experimental outcome validates the superiority of the ANN-SCA-SQP algorithm.

A Hybrid Metaheuristic Based on Neurocomputing for Analysis of Unipolar Electrohydrodynamic Pump Flow.

A unipolar electrohydrodynamic (UP-EHD) pump flow is studied with known electric potential at the emitter and zero electric potential at the collector. The model is designed for electric potential, charge density, and electric field. The dimensionless parameters, namely the electrical source number (Es), the electrical Reynolds number (ReE), and electrical slip number (Esl), are considered with wide ranges of variation to analyze the UP-EHD pump flow. To interpret the pump flow of the UP-EHD model, a hybrid metaheuristic solver is designed, consisting of the recently developed technique sine-cosine algorithm (SCA) and sequential quadratic programming (SQP) under the influence of an artificial neural network. The method is abbreviated as ANN-SCA-SQP. The superiority of the technique is shown by comparing the solution with reference solutions. For a large data set, the technique is executed for one hundred independent experiments. The performance is evaluated through performance operators and convergence plots.

Theoretical Analysis on Absorption of Carbon Dioxide (CO2) into Solutions of Phenyl Glycidyl Ether (PGE) Using Nonlinear Autoregressive Exogenous Neural Networks.

In this paper, we analyzed the mass transfer model with chemical reactions during the absorption of carbon dioxide (CO2) into phenyl glycidyl ether (PGE) solution. The mathematical model of the phenomenon is governed by a coupled nonlinear differential equation that corresponds to the reaction kinetics and diffusion. The system of differential equations is subjected to Dirichlet boundary conditions and a mixed set of Neumann and Dirichlet boundary conditions. Further, to calculate the concentration of CO2, PGE, and the flux in terms of reaction rate constants, we adopt the supervised learning strategy of a nonlinear autoregressive exogenous (NARX) neural network model with two activation functions (Log-sigmoid and Hyperbolic tangent). The reference data set for the possible outcomes of different scenarios based on variations in normalized parameters (α1, α2, ß1, ß2, k) are obtained using the MATLAB solver "pdex4". The dataset is further interpreted by the Levenberg-Marquardt (LM) backpropagation algorithm for validation, testing, and training. The results obtained by the NARX-LM algorithm are compared with the Adomian decomposition method and residual method. The rapid convergence of solutions, smooth implementation, computational complexity, absolute errors, and statistics of the mean square error further validate the design scheme's worth and efficiency.