Setting priorities for high-cost medications in public hospitals in Australia: should the public be involved?

AIM: To explore healthcare decision makers' perceptions about public involvement in setting priorities for high-cost medications (HCMs) in public hospitals in Australia. METHODS: In-depth, semi-structured interviews were conducted with 24 decision-makers (executive directors of hospitals, area health service managers, directors of hospital pharmacy departments and senior medical doctors) in a Sydney Area Health Service. Interviews were digitally recorded, transcribed verbatim, thematically content analysed and coded. RESULTS: The majority of participants perceived that the 'rationing debate' needs to happen in Australia. The community at large should be encouraged to understand that healthcare resources are limited and choices need to be made. The perspectives of the public, according to participants, were considered diverse (tax payers, patients, consumers). Owing to the complexities of the healthcare system, their involvement of the public in decision-making regarding access to HCMs in public hospitals was considered limited. For participants, the role of the public was likely to be at the macro level, deciding how much they were prepared to spend on healthcare. CONCLUSION: The role of the public in setting priorities for HCMs in public hospitals was perceived by these healthcare decision makers as limited. However since rationing is unavoidable, there should be an explicit debate about the principles and issues concerned.

Successful salvage of a recurrently dislocating Oxford medial unicompartmental bearing.

Dislocation of the bearing of the Oxford medial unicompartmental arthroplasty is a rare but serious complication. We report the case of a 48-year-old woman with a classic anteromedial arthritis who had 2 bearing dislocations within the first 3 months after index surgery. These were attributable to posterior bony impingement of the bearing against a small retained osteophyte. After arthroscopic resection of the osteophyte, she has retained her original components with no further dislocations or signs of impending failure 7 years later. This case report emphasizes the importance of osteophyte removal from the back of the femoral condyle during an Oxford unicompartmental arthroplasty.

Pharmacy students' intention to practise in a rural setting: measuring the impact of a rural curriculum, rural campus and rural placement on a predominantly metropolitan student cohort.

OBJECTIVE: To compare pharmacy students' intention to practise in a rural setting expressed in their first year of university with that expressed during their final year. DESIGN: Longitudinal survey of students in their first and final years. SETTING: Tertiary educational institution. PARTICIPANTS: Predominantly metropolitan pharmacy students. INTERVENTIONS: Students were exposed to a rural curriculum, rural campus and rural placement or rural placement alone during their degree. MAIN OUTCOME MEASURE: Change in proportion of students expressing an intention to practise in a rural setting following registration. RESULTS: The proportion of respondents who indicated an intention to practise in a rural setting was 21.6% (27/125) in 2006 compared with 11.2% (14/125) in 2003. This was a statistically significant increase of 10.4% (P = 0.001) over the four years. Positive influences on students' intention to practise in a rural setting were: rural background (P = 0.012); rural placement (either two weeks or 12 weeks) (P = 0.002); having been enrolled in the BPharm (Rural) (P = 0.001). CONCLUSIONS: This study confirmed the work of others in that the students most likely to express an intention to practise in a rural setting were those from a rural background who elected to undertake and complete a rural degree involving a rural placement. A follow-up survey will be conducted to establish whether their stated intention as students has translated to rural practice in reality.

Human organ/tissue growth algorithms that include obese individuals and black/white population organ weight similarities from autopsy data.

Physiologically based pharmacokinetic (PBPK) models need the correct organ/tissue weights to match various total body weights in order to be applied to children and the obese individual. Baseline data from Reference Man for the growth of human organs (adrenals, brain, heart, kidneys, liver, lungs, pancreas, spleen, thymus, and thyroid) were augmented with autopsy data to extend the describing polynomials to include the morbidly obese individual (up to 250 kg). Additional literature data similarly extends the growth curves for blood volume, muscle, skin, and adipose tissue. Collectively these polynomials were used to calculate blood/organ/tissue weights for males and females from birth to 250 kg, which can be directly used to help parameterize PBPK models. In contrast to other black/white anthropomorphic measurements, the data demonstrated no observable or statistical difference in weights for any organ/tissue between individuals identified as black or white in the autopsy reports.

Public views on priority setting for high cost medications in public hospitals in Australia.

OBJECTIVE: To gather information about views of members of the general public about access to High Cost Medications (HCMs) in public hospitals. METHODS: A structured questionnaire was administered to members of the general public. Individuals were approached in train stations, shopping centres and different venues in the Sydney metropolitan area. People were eligible to answer the survey if they were: over 18 years of age, Australian permanent residents and able to complete the questionnaire in English. RESULTS: Two hundred people completed the survey. Of these 56% were females, 47% were married, 84% spoke English at home, 88% were working either full-time or part-time, 61% had a university degree, 27% had a household annual income greater than 100,000 dollars and 68% had private health insurance. Participants considered factors such as treatment outcomes, quality of life and current health status when determining who should have access to HCMs. Participants wanted resources to be allocated to provide the 'greatest benefit to the greatest number of people'. Almost half the respondents did not want direct involvement in decision-making, however, 38% did. CONCLUSIONS: The results offered support for indirect involvement through the development of a process to involve community members in discussion on policy on the provision of treatment and services within health-care institutions and specifically, to seek the views of members of the public on the provision of HCMs and expensive services within public hospitals.

Provision of pharmaceuticals in Australian hospitals: equity of access?

In Australia, medicines are funded under a complex set of financial arrangements. Currently there are dual funding arrangements in public and private hospitals that can lead to differences in patient access to medications. There are considerable concerns about the consequences of the fragmentation and "lack of cohesion of the system". Some decision-makers consider there are inequities because of the funding models in place. What follows is a description of this system.

Issues with prescribed medications in Aboriginal communities: Aboriginal health workers' perspectives.

INTRODUCTION: The health of Indigenous Australians remains appalling. The causes of this situation are multi-factorial, however one contributing factor is poor medication compliance within Aboriginal populations. Anecdotal evidence provided by Aboriginal health workers in western New South Wales (NSW), Australia, has suggested that there are problems associated with the use of prescribed medications within the Aboriginal community. Aboriginal health workers form a core component of the Aboriginal health service sector and they have an in-depth knowledge of the community and its healthcare provision, as well as a familiarity with clinic patients and families. As such they are an important group whose opinions and beliefs about medication use in the Aboriginal population should be investigated. While there have been studies on the issues of prescribing in Aboriginal communities and access to medications, limited investigation into the use of prescribed medicines in Aboriginal communities and the role of the pharmacist in that process, has taken place. Therefore, this research aimed to identify the type of and reasons for inappropriate use of prescribed medications within Aboriginal communities serviced by the Mid Western Area Health Service (since incorporated into the Greater West Area Health Service) as perceived by the Aboriginal health workers in the area, and to explore strategies in conjunction with those Aboriginal health workers to address identified issues. METHODS: Qualitative, in-depth interviews were held with 11 Aboriginal health workers employed in Community Health Centres and hospitals in the Mid Western Area Health service of NSW. The interviews were audiotaped and transcribed verbatim. The transcripts were content analysed for emerging themes. The interviews explored the beliefs, perceptions and experiences of the Aboriginal health workers regarding prescribed medication use, the role of the pharmacist, and identification of future strategies to improve medication use in local Aboriginal communities. RESULTS: The Aboriginal health workers reported a general lack of access to medications and frequent inappropriate use of medications due to limited understanding, literacy and information all of which lead to non-compliance with instructions. Medication sharing was common in their communities. They reported that many Aboriginal people were uncomfortable seeking medicines advice, and the consumer medicine information provided was often difficult to understand, culturally inappropriate and unlikely to be utilised. Strategies suggested to improve pharmacist services and access to the services were a more 'Aboriginal friendly' environment, relationship development between pharmacists and Aboriginal health workers, cultural awareness programs for pharmacists and their staff, provision of disease state management services and medicine education programs by pharmacists for Aboriginal health workers. CONCLUSION: Medication misunderstandings and non-compliance within the Aboriginal community frequently occur. Suggestions to improve access, understanding and compliance, along with the education and training of Aboriginal health workers may provide tools for self-determination. Pharmacists may be well positioned to provide Aboriginal health workers with medicines information and patient education skills, and encourage the effective use of medicines within the Aboriginal community.

Effect of different sitting postures on lung capacity, expiratory flow, and lumbar lordosis.

OBJECTIVE: To investigate the effect of sitting posture on lung capacity and expiratory flow (LC-EF) and lumbar lordosis. DESIGN: Repeated measures on 1 group of subjects in 4 postures. SETTING: Laboratory. PARTICIPANTS: Seventy able-bodied volunteers. INTERVENTIONS: Postures were assumed randomly: normal, with full ischial support and flat lumbar support; slumped, with the pelvis positioned in the middle of seat while leaning against the backrest; against the back part of the seat without ischial support (WO-BPS), with partially removed ischial support and an enhanced lumbar support; and standing. MAIN OUTCOME MEASURES: For LC-EF, forced vital capacity, maximum forced expiratory flow, forced expiratory volume in 1 second, and peak expiratory flow; and lumbar lordosis. RESULTS: All LC-EF measures in standing were significantly superior to those in slumped and normal sitting, and 4 measures were significantly higher than in WO-BPS. In slumped sitting, LC-EF significantly decreased from that in normal sitting. WO-BPS sitting significantly increased 4 of the LC-EF measures from those in the normal sitting. Lumbar lordosis was the highest in standing and progressively decreased in WO-BPS, normal, and slumped sitting. CONCLUSIONS: Slumped sitting significantly decreased LC-EF and lumbar lordosis. Because it increases the lumbar lordosis and promotes LC-EF, the WO-BPS posture may be a better seating option for people sitting for a prolonged time.

Impact on medication use and adherence of Australian pharmacists' diabetes care services.

OBJECTIVE: To assess the effect of a specialized service implemented in community pharmacies for patients with type 2 diabetes on medication use and medication-related problems. DESIGN: Parallel group, multisite, control versus intervention, repeated measures design, with three different regions in New South Wales, Australia, used as intervention regions, then matched with control regions as much as possible. INTERVENTION: After initial training, pharmacists followed a clinical protocol for more than 9 months, with patient contact approximately monthly. Each patient received an adherence assessment at the beginning and end of the study, adherence support, and a medication review as part of the intervention. MAIN OUTCOME MEASURES: Risk of nonadherence using Brief Medication Questionnaire (BMQ) scores and changes to medication regimen. RESULTS: Compared with 82 control patients, 106 intervention patients with similar demographic and clinical characteristics had significantly improved self-reported nonadherence as reflected in total BMQ scores after 9 months. The mean (+/-SD) number of medications prescribed at follow-up in intervention participants decreased significantly, from 8.2+/-3.0 to 7.7+/-2.7. No reduction was observed among the control patients (7.6+/-2.4 and 7.3+/-2.4). The overall prevalence of changes to the regimen was also significantly higher in the intervention group (51%) compared with controls (40%). CONCLUSION: Community pharmacists trained in medication review and using protocols in collaboration with providers improved adherence in patients with type 2 diabetes, reduced problems patients had in accessing their medications, and recommended medication regimen changes that improved outcomes.

Implementation and evaluation of Australian pharmacists' diabetes care services.

OBJECTIVE: To implement and evaluate a specialized service for type 2 diabetes mellitus in the community pharmacy. DESIGN: Parallel group, multisite, control versus intervention, repeated measures design, with three different regions in New South Wales, Australia, used as intervention regions, then matched with control regions as much as possible. INTERVENTION: Following training, pharmacists followed a clinical protocol over 9 months, with approximately monthly intervention site visits during which blood glucose readings were downloaded and discussed with the patient, interventions were documented, and goals set with each patient. MAIN OUTCOME MEASURES: Quality of life, well-being, risk of nonadherence, and glycosylated hemoglobin (A1C) values at the beginning and end of the study. Blood glucose levels were measured in intervention patients only. RESULTS: A total of 106 intervention and 82 control patients completed the study. Patient groups were similar at baseline. Pharmacists delivered 1,459 interventions and blood glucose levels were significantly reduced in all intervention regions. The proportion of patients with A1C values greater than 7% was similar in control sites at baseline (54%) and after 9 months (61%). In intervention sites this proportion was significantly reduced, from 72% at baseline to 53% after 9 months. Well-being and the risk of nonadherence were significantly improved in intervention patients. CONCLUSION: Implementation of a specialized service for diabetes in community pharmacy resulted in better diabetes control and health care outcomes for the patient.

Acceptability of willingness to pay techniques to consumers.

OBJECTIVE: The purpose of this study was to assess and compare the proportion of usable responses and protest votes obtained with two willingness to pay (WTP) techniques, contingent valuation (CV) and discrete choice experiment (DCE) and to assess the acceptability of the techniques to respondents. SETTING AND PARTICIPANTS: Pregnant women attending the public antenatal clinics of a Sydney teaching hospital were surveyed. MAIN VARIABLES STUDIED: Preference for either Treatment A (artificial rupture of the membranes followed by intravenous oxytocin) or Treatment B (prostaglandin E2 gel followed by oxytocin if necessary) was assessed. Then WTP for the preferred treatments was assessed using CV and WTP for specific attributes of the treatments in the DCE. In addition, the acceptability of the two techniques was compared in terms of responses deemed to be valid according to defined criteria, protest votes and comments recorded by consumers. RESULTS: With the CV, 74% of respondents chose gel and their maximum WTP was Aus$178 compared with $133 for the alternative. A total of 68% of responses were deemed to be valid including 5% who may have been expressing a protest vote. With the DCE, respondents were WTP $55 for every 1 h reduction in the length of time from induction to delivery. A total of 72% of responses were deemed valid and only two of these 258 women were considered to have expressed a protest vote. CONCLUSIONS: Only a small number of women expressed objections to the use of WTP questions in health-care and the majority of women completed both questions successfully.

Measurement of consumer preference for treatments used to induce labour: a willingness-to-pay approach.

AIM: The purpose of the study was to assess the acceptability to consumers of two methods of induction of labour using a willingness-to-pay (WTP) approach. The methods compared were amniotomy plus oxytocin and prostaglandin E2 vaginal gel, followed by oxytocin if necessary. METHODS: A description of each method was presented, in questionnaire format, to pregnant women attending a public hospital ante-natal clinic. Women were asked to choose one of the two treatments, then give a valuation in dollar terms for both their preferred treatment and the alternative. RESULTS: It was found that 73.7% of patients preferred gel. The mean maximum WTP for amniotomy plus oxytocin was Aus$133 while that for gel was Aus$178 (P=0.0001). Those who chose amniotomy plus oxytocin were WTP 90% more for their preferred treatment compared with the alternative (Aus$180 vs. Aus$95). Similarly, those who preferred gel were WTP 90% more for their preferred treatment compared with the alternative (Aus$222 vs. Aus$119). CONCLUSION: Consumers were able to assess drug information provided on the two therapies, make an informed choice and to value that choice. Information obtained in this way, combined with information on costs, could be used in policy decision-making.