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Z Naturforsch C J Biosci ; 72(11-12): 477-482, 2017 Oct 26.
Artigo em Inglês | MEDLINE | ID: mdl-28525357

RESUMO

Phytochemical investigation of the aerial parts of Sansevieria trifasciata, one of the most common Dracaenaceae plants, has resulted in the isolation of a new dihydrochalcone derivative named trifasciatine C (1), four previously unreported steroidal saponins as two pairs of inseparable regioisomers: trifasciatosides K/L (2/3), M/N (4/5), together with the known 1,2-(dipalmitoyl)-3-O-ß-D-galactopyranosylglycerol (6), aconitic acid (7), and 1-methyl aconitic acid (8). Their structures were elucidated mainly by extensive spectroscopic analysis (1D and 2D nuclear magnetic resonance) and high-resolution electronspray ionization-mass spectrometry, as well as chemical methods and comparison of their spectral data with those of related compounds. Compounds 2/3 and 4/5 were evaluated for their antiproliferative activity on Hela cells, and no significant effect was observed.


Assuntos
Chalconas/isolamento & purificação , Galactosídeos/isolamento & purificação , Sansevieria/química , Saponinas/isolamento & purificação , Ácido Aconítico/análogos & derivados , Ácido Aconítico/isolamento & purificação , Ácido Aconítico/farmacologia , Sequência de Carboidratos , Proliferação de Células/efeitos dos fármacos , Chalconas/farmacologia , Galactosídeos/farmacologia , Células HeLa , Humanos , Saponinas/farmacologia , Estereoisomerismo
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