Cost-effectiveness of cognitive self-therapy in patients with depression and anxiety disorders.

OBJECTIVE: Self-therapy interventions could potentially reduce healthcare expenses and the need for care in the treatment of depression and anxiety disorders. This study assessed the cost-effectiveness of cognitive self-therapy (CST) in patients with these disorders. METHOD: A total of 151 patients were randomly assigned to CST or treatment as usual (TAU), and followed during 18 months. The Symptom Checklist 90 (SCL-90) was the primary outcome measure of the study. The reference year was 2003 (US$1.00 = euro 0.92). RESULTS: Mean costs of patients in the CST group (US$4364) were lower than that of the patients who received TAU (US$5241). The results of the SCL-90 were slightly in favour of CST. Valuing an additional unit of health outcome at US$108 will lead to an 83% probability that CST is cost-effective. CONCLUSION: Cognitive self-therapy appears to be cost-effective. Wider implementation of CST may relieve the burden of many patients with emotional disorders whose treatment needs cannot be met in current healthcare systems.

Burst fractures of the thoracolumbar spine: changes of the spinal canal during operative treatment and follow-up.

Although multiple studies have concluded operative decompression of a traumatically narrowed spinal canal is not indicated because of spontaneous remodeling, instrumental decompression is frequently used as part of the operative treatment of spinal fractures. To investigate the process of remodeling, we studied the diameter of the spinal canal in 95 patients with burst fractures at the thoracolumbar junction (T9-L2). To measure and compare the spinal canal's diameter we used either computed tomography (CT) scans or radiographs, made preoperatively, postoperatively, after 9 months and after 24 months. In lateral plain radiographs we found that the initial percentage of cases with bony canal narrowing preoperatively of 76.5 was reduced to 18.4% postoperatively, to 8.2% at 9 months, and to 2.4% at 24 months. In CT scans in a selection of patients, the mean residual diameter of the spinal canal was 53% preoperatively and 78% at 24 months. The posterior segmental height increases during operation and decreases in the respective periods after operation. So ligamentotaxis can only play a role in the perioperative period. We conclude that a significant spontaneous remodeling of the spinal canal follows the initial surgical reduction. Two years after operation, bony narrowing of the spinal canal is only recognizable in 2.4% of the patients on plain lateral radiographs. The remodeling of the spinal canal can be seen on plain radiographs, although not as accurately as on CT scans.

Classificational problems in ligamentary distraction type vertebral fractures: 30% of all B-type fractures are initially unrecognised.

The clinical records, operation records, X-rays and CT-scans of 160 operatively treated patients with A-type and B-type spinal fractures were evaluated in a retrospective study. The preoperative diagnosis was compared with the postoperative diagnosis. Analysis of characteristics of patients with A-type fractures (without the unrecognised B-type fractures), initially unrecognised B-type (uB) fractures, and B-type fractures (without the unrecognised B-type fractures) was performed. We analysed the age of the patients, the respective fracture levels, neurologic deficit, anterior wedge angles (AWA), anterior corporal height (ACH), posterior corporal height (PCH), and the percentage of frontal corporal collapse (FCC). The t-test was used for statistical analysis. The mean age of patients in each group did not show a significant difference. The group of unrecognised B-fractures had a more caudal fracture level than the recognised B-type fractures. The fracture levels of the A-group and the uB-group patients showed no difference using the t-test. The percentage of patients with spinal fractures with neurologic deficit is 16% in the A-type fracture group, 12% in the uB-fracture group and 50% in the B-type group. The preoperative classification of patients in the A-group and in the uB-group showed that patients in the uB-group have more than proportional relatively simple preoperative A-fractures. The AWA and ACH did not show significant differences between the groups. The mean PCH of the uB-group was higher than the PCH of the A-group. No differences were measured between the uB-group and the B-group. The mean percentages of frontal corporal collapse (FCC) did not show a significant difference. Thirty percent of B-type fractures are misdiagnosed when plain X-rays and CT scans with 2D reconstructions are used as the only preoperative diagnostic tools. A large PCH with a normal interspinous distance should raise the suspicion of a B-type lesion. A large AWA does not point to a ligamentary B-type fracture.

Comparison of outcome after pediatric liver transplantation for metabolic diseases and biliary atresia.

UNLABELLED: Metabolic diseases (MD) are the second largest indication group for orthotopic liver transplantation (OLTx) in children after biliary atresia (BA). A better outcome after transplantation can be expected because of a better pretransplant condition and the absence of previous abdominal surgery. To prove this statement, patient survival, graft survival, and morbidity were compared between a group of 24 for MD and 52 for BA consecutively transplanted children. The actuarial one- and five-year patient survival rates for MD were 96% and 84%, and for BA 84% and 70%, respectively (p logrank test = 0.17). Three MD children (13%) and 15 BA children (29%) died. The actuarial one- and five-year graft survival rates for MD were 75% and 58%, and for BA 75% and 64%, respectively (p logrank test = 0.76). Seven MD children (29%) and 11 BA children (21%) were retransplanted. Postoperative bleeding and gastrointestinal complications occurred less frequent (4% vs. 18% and 4% vs. 14%, respectively), whereas biliary complications, viral infections, and acute rejection occurred more frequently (38% vs. 21%, 29% vs. 15%, and 50% vs. 37%, respectively) in MD children. The difference in the incidence of the various postoperative complications between both groups was not statistically significant. The mean ICU and ventilator stay was 7.5 and four days, respectively, in MD children and 16 and 10 days, respectively, in BA children (p = ns). The mean infection, complication, intervention, and retransplantation rate was equal in both groups. CONCLUSION: Mortality and morbidity after pediatric liver transplantation for MD and BA are not different despite the better starting point for children with MD.

Thoracolumbar spinal fractures: radiological results of transpedicular fixation combined with transpedicular cancellous bone graft and posterior fusion in 183 patients.

In internal posterior fixation of thoracolumbar fractures combined with transpedicular cancellous bone graft and posterior fusion of the intervertebral facet joints at the level of the destroyed end plate it is still uncertain as to whether significant vertebral body collapse and loss of correction of the regional angle (RA) and the intervertebral angle (IVA) occur (after removal of the implants). These questions were investigated in a retrospective study of 183 consecutive patients, 18-65 years old, with a spinal fracture between the 9th thoracic and the 5th lumbar vertebral body (inclusive), treated operatively between 1988 and 1996 (27% had objective neurological deficit, 37% had multiple injuries). According to the Comprehensive Classification, 128 type A, 32 type B and 21 type C fractures were identified preoperatively. Changes in the anterior wedge angle (AWA), the IVA and the RA were measured preoperatively, and within 1 month, 9 months and 24 months postoperatively. The effect of implant failure was also evaluated. The normality of the distribution was tested using the Kolmogorov-Smirnov (K-S) test. The one-sample runs test and the t-test were used to evaluate angle changes. Angles in patients with and without implant failure were compared using the unpaired t-test. Almost complete restoration of the AWA could be achieved during operation. Postoperative changes in AWA were either very small or not significant. The reduced vertebral body did not collapse after 9 months, when most of the patients (170) underwent removal of the implants, but significant changes in IVA were found after implant removal. Correction of the RA was statistically significant before implant removal, but the RA 2 years after surgery had become almost the same as the preoperative values. Changes at the level of the intervertebral space, occurring after implant removal, contributed to the loss in the RA. Broken pedicle screws (10.9% of the patients) resulted in significant changes in the AWA and RA before implant removal, but did not influence the IVA.

Bronchiolitis obliterans syndrome after lung transplantation and health-related quality of life.

The present study was undertaken to assess the relationship between health-related quality of life (HRQOL) and bronchiolitis obliterans syndrome (BOS), as both represent important parameters of outcome after lung transplantation. HRQOL was measured both cross-sectionally and longitudinally by standardized patient self-administered questionnaires, including the Nottingham Health Profile, the State-trait Anxiety Inventory, the Zung Self-Rating Depression Scale, and the Index of Well-Being. Data were collected at 4 and 7 mo, and every 6 mo afterwards for as long as 49 mo post-transplantation. The number of patients who completed the questionnaires varied from 72 at 4 mo, to 27 at 49 mo after transplantation. Cross-sectionally, the patients with BOS reported persistently statistically significantly more restrictions on the dimensions energy and physical mobility of the Nottingham Health Profile compared with patients without BOS. Other domains, i.e., pain, sleep, social interaction, and emotional reactions, were not affected. Additionally, patients with BOS reported statistically significantly more depressive symptoms and anxiety 1 and 2 yr after transplantation. Results from the longitudinal analysis support these findings, although no change in depressive symptoms could be found after onset of BOS. This study suggests that all lung transplant recipients improve in HRQOL. The development of BOS, however, is associated with a significantly reduced HRQOL.

Does lung transplantation prolong life? A comparison of survival with and without transplantation.

BACKGROUND: Because of the assumed beneficial effect of lung transplantation on survival, controlled trials to assess the therapeutic benefit of lung transplantation are considered to be unethical. Therefore other methods must be used to provide control data. In this study the effect of lung transplantation on survival for patients with end-stage pulmonary disease was analyzed, with waiting list survival rates used as control data. METHODS: The analysis was based on 157 consecutive patients who were put on the waiting list of the Dutch lung transplantation program during the period November 1990 to January 31, 1996, of whom 76 underwent transplantation. Following the principles of control group estimation as set out in the context of heart transplantation, a stepwise approach was used to arrive at a multivariate time-dependent Cox regression model. The following prognostic variables were included in the analyses: age, forced expiratory volume in 1 second, partial pressure of carbon dioxide, partial pressure of oxygen, and diagnosis. RESULTS: The 1- and 2-year waiting list survival rates were 78% and 58%, respectively. The 1- and 2-year transplantation survival rates (i.e., survival from placement on the waiting list, including posttransplantation survival) were 79% and 64%, respectively. The multivariate time-dependent Cox analysis showed that lung transplantation reduced the risk of dying by 55% (95% confidence interval, 3% to 79%). For patients with emphysema the risk of dying was estimated to be 77% lower than for patients with other diagnoses (96% confidence interval, 50% to 89%). CONCLUSIONS: With Cox regression, adjusting for age, forced expiratory volume in 1 second, partial pressure of carbon dioxide, partial pressure of oxygen, and diagnosis, lung transplantation showed a statistically significant effect on survival in selected patients with end-stage pulmonary disease.

Poor initial graft function after orthotopic liver transplantation: can it be predicted and does it affect outcome? An analysis of 125 adult primary transplantations.

Donor liver shortage is a persistent problem in liver transplantation. A more liberal donor acceptance policy may be a possible solution. However, this might put recipients at risk for initial poor function or even non-function of the graft. Therefore risk factors for initial graft dysfunction should be identified, preferably by using an uniform definition of primary graft dysfunction or non-function. We retrospectively analysed 125 adult liver transplantations in order to identify risk factors for initial poor function and primary non-function. Donor, recipient pretransplant and surgical parameters were evaluated. Since there is no consensus on the criteria of dysfunction we used two definitions known from literature. No risk factors for postoperative dysfunction could be identified for either of the two definition sets. Furthermore, the definition set that included ALAT, prothrombin time and bile production in the first 72 h to identify poor graft function showed no relation with graft or recipient outcome. The other set, using ASAT and prothrombin time, determined from day 2 to day 7, showed that patients with a primary dysfunction had significantly higher morbidity and mortality compared to patients with a well functioning graft. We conclude that initial poor function after liver transplantation remains unpredictable, irrespective of the way it is defined. Moreover, our analysis shows that initial poor function can also develop in recipients that receive 'non-marginal' grafts without prolonged ischemia times. These results may support a more liberal selection of donor livers.

Selective treatment of early acute rejection after liver transplantation: effects on liver, infection rate, and outcome.

To evaluate the results of selective treatment of biopsy-proven mild acute rejection episodes, we retrospectively studied 1-week liver biopsies of 103 patients with a primary liver graft in relation to liver function tests. The overall incidence of rejection was 35%. In four patients the biopsy showed histological features consistent with rejection; in 27 patients it showed mild acute rejection (grade 1), and in 5 patients it showed moderate acute rejection (grade 2). Study group 1 consisted of 19 untreated patients with grade 1 rejection and group 2 of 8 treated patients with grade 1 rejection. At 30 and 90 days, no differences in liver function tests were found. The infection rate, histology after 1 year, and survival in the two groups did not differ. It may, therefore, be concluded that withholding treatment in histologically proven mild acute rejection is possible in selected patients based on histological, biochemical, and clinical criteria. This may reflect the functional diversity of morphologically similar lymphocytic infiltrates observed in graft biopsies showing features of mild acute rejection.

The need for lung transplantation in The Netherlands.

The aim of this study was to assess the future need for lung transplantation in the Netherlands in the absence of limiting factors, such as a shortage of donor organs. The need was estimated using two different methods. In method 1, estimation of the need was based on data from the Dutch lung transplantation program, collected during a 4-year period (1 April 1992 until 31 March 1996). In method 2, the need was estimated using national mortality data over a 5-year period (1987-1991) preceding the start of the Dutch lung transplantation program. The results of both methods were corrected for known factors of distortion. The number of lung transplantations needed in the Netherlands in the future was estimated to range from 50 to 80 a year, which corresponds to 3.2-5.2 transplantations per million inhabitants per year. Considering the current supply of donor lungs in the Netherlands, only about one-third of the patients in need of a lung transplant in the future will be able to receive one.

Analysis of growth in children after orthotopic liver transplantation.

Growth after pediatric liver transplantation is an important factor in determining the quality of life. We collected data on height, skeletal age, and liver function of 45 consecutive pediatric transplant recipients and assessed the influence of primary diagnosis, liver function, and immunosuppressive regimen on their growth. Height and skeletal age were plotted as median standard deviation scores versus years post-transplantation. Growth, in terms of both height and skeletal age, were continuous without catch-up growth. Primary diagnosis was found to have no influence on height and poor liver function had a negative effect on both height and skeletal growth. A higher alternate day prednisolone maintenance dose also had negative effect on skeletal growth. Thus, it can be concluded that a pretransplant lack of growth will not be restored and is an indication for early transplantation in end-stage liver disease, especially in younger children.

Long term benefits of rehabilitation at home on quality of life and exercise tolerance in patients with chronic obstructive pulmonary disease.

BACKGROUND--Pulmonary rehabilitation has been shown to have short term subjective and objective benefits for patients with chronic obstructive pulmonary disease (COPD). However, appropriately controlled studies have not previously been performed, nor have the benefits of different types of continuation programme for rehabilitation been investigated. Both these problems have been addressed in a single study of the long term effects of once monthly physiotherapy versus once weekly physiotherapy at home after a comprehensive home rehabilitation programme on quality of life and exercise tolerance in patients with COPD. METHODS--Thirty six patients with severe airways obstruction (mean SD) forced expiratory volume in one second (FEV1) 1.3(0.4) 1, FEV1/inspiratory vital capacity (IVC) 37.2(7.9)%) were studied. Twenty three patients followed a rehabilitation programme at home for 18 months consisting of physiotherapy and supervision by a nurse and general practitioner. During the first three months all 23 patients visited the physiotherapist twice a week for a 0.5 hour session. Thereafter, 11 patients (group A) received a session of physiotherapy once weekly while 12 patients (group B) received a session of physiotherapy once a month. The control group C (13 patients) received no rehabilitation at all. Quality of life was assessed by the Chronic Respiratory Questionnaire, exercise tolerance by the six minute walking distance, and lung function by FEV1 and IVC. Outcome measures were assessed at baseline and at three, six, 12, and 18 months. RESULTS--Long term improvements in quality of life were found in patients in groups A and B, but not in those in group C compared with baseline, but these only reached significance in group B at all time points. Patients in group B had a higher quality of life than those in group C only at three and 12 months. There was a decrease in both six minute walking distance (at 12 and 18 months) and IVC (at three, 12, and 18 months) in patients in group C compared with the baseline measurement. Between groups analysis showed no differences for six minute walking distance, FEV1, and IVC. CONCLUSIONS--This study is the first to show that rehabilitation at home for three months followed by once monthly physiotherapy sessions improves quality of life over 18 months. The change in quality of life was not associated with a change in exercise tolerance.

[Comparison of 2 scales in the assessment of injury severity in seriously injured patients]. / Vergelijking van twee schalen voor het meten van letselernst bij ernstig gewonde patiënten.

We compared the Abbreviated Injury Scale (AIS-85) and the Hospital Trauma Index (HTI) in seriously injured patients. The effect of these scales on the application of Injury Severity Scores (ISS) was investigated. Furthermore, the predictive value on mortality of the AIS/ISS and the HTI/ISS was determined. Subjects were 932 seriously injured patients (HTI/ISS score greater than or equal to 18) admitted to University Hospital Groningen between 1985 and 1990. A quantitative and a qualitative comparison were performed. Logistic regression was used to estimate the predictive value of the AIS/ISS and the HTI/ISS on mortality. The AIS/ISS and HTI/ISS differed quantitatively and qualitatively. The average HTI/ISS score was ten points higher than the average AIS/ISS. By combining specific regions of the scales the predictive value could be improved. The ISS scores were incomparable. Consequently in future studies the method used to calculate the ISS score should be mentioned.

The influence of an improved preservation solution on prognostic factors for graft survival in pediatric liver transplantation.

We investigated the influence of Eurocollins (EC) and University of Wisconson solution (UW) on prognostic factors for graft survival after pediatric liver transplantation. The 1-year graft survival was studied for 30 patients in which 38 transplantations were performed between 1982 and 1988. We preserved 19 grafts in EC and the other 19 grafts in UW solution. For grafts preserved in EC, the median preservation time was 5 h compared to 10.8 h for grafts preserved in UW solution (P < 0.01). Graft survival at 1 year was equivalent in both groups (63%). No significant differences were observed between the two groups for the following variables: patient diagnosis, child-pugh score, age, operative time, anhepatic phase, blood loss, morbidity, ICU stay, donor age and graft survival. Multivariate analysis indicated that in the EC group anhepatic phase, blood loss and preservation time were significant predictors of graft survival whereas in the UW group, none of these factors appeared to be significant. We concluded that UW was superior to EC solution in pediatric liver transplantations because it allowed longer preservation times, the length of the anhepatic phase was less important and the tolerance for blood loss seemed to be extended.

Cellular damage and early metabolic function of transplanted livers stored in Eurocollins or University of Wisconsin solution.

In a clinical setting, the effect of Eurocollins (EC) and University of Wisconsin solution (UW) on liver grafts were studied in the early reperfusion phase of liver transplantation. Blood samples were drawn before and after declamping of the portal vein in a group of 11 transplants with EC-perfused livers, and a group of 12 transplants with UW-perfused livers. Parenchymal damage was assessed by the LDH, AST, and ALT, and purine degradation by measuring the uric acid levels. Metabolic function was determined by the serum bile acids and the plasma amino acids, i.e. (valine + leucine + isoleucine)/(phenylalanine + tyrosine) ratio. Donor and pretransplant recipient parameters were almost identical. The cold ischemia time of both groups differed significantly. The results show the following: a significant difference between both the LDH and the uric acid levels in the two groups was revealed, with a smaller increase of the LDH levels and no increase of the uric acid levels in the UW group. Metabolic activity, as measured from the bile acids and the amino acid profile in the peripheral blood, was identical in both groups. We conclude that both EC-stored and UW-stored liver grafts show immediate metabolic function after reperfusion. The amount of metabolic function was equal in both groups, notwithstanding longer cold ischemia time in the UW group. In addition, more parenchymal damage occurred in the EC group.

Secular trends in abortion attitudes: 1975-1980-1985.

In this study, we compared the attitudes toward abortion of respondents from the National Opinion Research Center's (NORC) General Social Survey (GSS) for the years 1975, 1980, and 1985. The major theme of the GSS is that an adequate description of changes in abortion attitudes is predicted on resolving the question of whether the six abortion items used in the surveys measure one or two dimensions. We used the Mokken method of scale analysis, a stochastic extension of Guttman scaling, to resolve this question. We concluded that the six items are unidimensional and, therefore, create a single scale to measure the changes in abortion attitudes across the three periods. The data revealed virtually no change from 1975 to 1980, but a significant, though small, drop in approval from 1980 to 1985.

PIP: The attitudes toward abortion of respondents from the National Opinion Research Center's (NORC) General Social Survey (GSS) for the years 1975, 1980, and 1985 were compared. Since its inception in 1972, the NORC GSS has asked respondents their opinion on legal abortion by using the same introductory statement as the Gallup polls, but it has offered the respondents the same 6 conditions as the National Fertility Survey (NFS): a strong chance of a serious defect in the baby (DEFECT); the woman is married and does not want any more children (NO MORE); the woman's own health is seriously endangered by the pregnancy (HEALTH): the family has a very low income and cannot afford any more children (POOR); the woman became pregnant as a result of rape (RAPE); and the woman is not married and does not want to marry the man (SINGLE). The samples sizes for the 1975, 1980, and 1985 surveys were 1490 participants, 1468, and 1534, respectively. A full probability sample design was used in the 1980 and 1985 surveys. Half the cases for the 1975 survey were selected using a full probability design, and the other half was selected by means of a block-quota design. The total sample size of 4498 was reduced to 3940, due to the decision to eliminate cases that had missing values on at least 1 of the 6 abortion items. The differences in the proportion of respondents who endorsed abortion under the 6 conditions in the 3 surveys lend themselves to grouping the items into 2 sets: medical and social reasons. The proportion who approved abortion remained stable from 1975 to 1980 but dropped slightly in 1985. This change appeared to be greater when the grounds for abortion were social: NO MORE, SINGLE, and POOR. The results of the Mokken analysis allowed for prediction, with a high degree of certainty, each individual's response pattern from his or her scale score. the number of items a respondent endorses, as Mokken (1971) pointed out, provides the best estimate of the individual's score on the latent variable being measured -- in this instance, the person's attitude toward abortion. The mean scale scores for the 3 periods were 4.13, 4.11, and 3.81 for the 1975, 1980, and 1985 periods, respectively. Summary variables were used to index the 1980 and 1985 periods. It was found that the change form 1975 to 1980 was not statistically significant but the drop in 1985 was.