1.
Clin Immunol
; 219: 108538, 2020 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32681980
RESUMO
IL-1 mediated auto-inflammatory diseases are characterised by episodes of unexplained fever, generalized and localized inflammation. The characteristic symptoms predominantly result from exaggerated activation of innate immune pathways. However, in some patients with typical IL-1 mediated diseases, chronic disease manifestations develop in the absence of acute inflammation, suggesting the involvement of adaptive immune pathways. We discuss clinical observations as well as novel insights in how chronic activation of innate immune pathways can lead to auto-immune disease features in patients with auto-inflammatory diseases and how we need to better understand these sequelae in order to improve treatment strategies.
Assuntos
Doenças Autoimunes/imunologia , Inflamação/imunologia , Interleucina-1/imunologia , Animais , Doenças Autoimunes/genética , Autoimunidade , Predisposição Genética para Doença , Humanos , Inflamassomos/genética , Inflamassomos/imunologia , Inflamação/genética , Proteína 3 que Contém Domínio de Pirina da Família NLR/imunologia , Pirina/imunologia
2.
Br J Dermatol
; 168(4): 688-91, 2013 Apr.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23528056