Improved accuracy and robustness of electron density profiles from JET's X-mode frequency-modulated continuous-wave reflectometers.

JET's frequency-modulated continuous wave (FMCW) reflectometers have been operating well with the current design since 2005, and density profiles have been automatically calculated intershot since then. However, the calculated profiles had long suffered from several shortcomings: poor agreement with other diagnostics, sometimes inappropriately moving radially by several centimeters, elevated levels of radial jitter, and persistent wriggles (strong unphysical oscillations). In this research, several techniques are applied to the reflectometry data analysis, and the shortcomings are significantly improved. Starting with improving the equilibrium reconstruction that estimates the background magnetic field, adding a ripple correction in the reconstructed magnetic field profile, and adding new inner-wall reflection positions estimated through ray-tracing, these changes not only improve the agreement of reconstructed profiles to other diagnostics but also solve density profile wriggles that were present during band transitions. Other smaller but also persistent wriggles were also suppressed by applying a localized correction to the measured beat frequency where persistent oscillations are present. Finally, the burst analysis method, as introduced by Varela et al. [Nucl. Fusion 46 S693 (2006)], has been implemented to extract the beat frequency from stacked spectrograms. Due to the strong suppression of spurious reflections, the radial jitter that sometimes would span several centimeters has been strongly reduced. The stacking of spectrograms has also been shown to be very useful for stacking recurring events, like small gas puff modulations, and extracting transport coefficients that would otherwise be below the noise level.

SARS-CoV-2 en Pediatría: abordaje de la transmisión, fisiopatología ehipótesis de presentación clínica / Sars-cov-2 in pediatrics: transmission approach, pathophysiology and clinical presentation hypothesis

La pandemia de COVID-19 causada por el síndrome respiratorio agudo severo coronavirus 2 (SARS-CoV-2) es una infección producida por inhalación de gotas o contacto directo con superficies infectadas. Los síntomas clínicos son similares a cualquier infección viral respiratoria aguda; la enfermedad suele ser más leve en los niños. El objetivo fue describir el abordaje de la transmisión, la fisiopatología y las manifestaciones clínicas del SARS-CoV-2 en población pediátrica. Se realizó una revisión bibliográfica en bases de datos académicas PubMed, LILACS, OVID-MEDLINE usando términos DECS-LILACS, aplicando filtros de búsqueda y se seleccionaron textos científicos e información relevante para la investigación. Los resultados evidencian una menor incidencia, prevalencia, hospitalizaciones e ingreso a unidades de cuidados intensivos. Es necesario corroborar las hipótesis planteadas para fortalecer estos conocimientos y determinar las características que predominan en la lesión pulmonar por infección de SARS-CoV-2 en Pediatría.(UA)

The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an infection caused by inhalation of droplets or direct contact with infected surfaces. The clinical symptoms are similar to any acute respiratory viral infection; the disease is usually milder in children. The objective was to describe the transmission approach, pathophysiology and clinical manifestations of SARS-CoV-2 in the pediatric population. A bibliographic review was carried out in PubMed, LILACS, OVID-MEDLINE academic databases using DECS-LILACS terms, applying search filters and scientific texts and relevant information for the research were selected. The results show a lower incidence, prevalence, hospitalizations and admission to intensive care units. It is necessary to corroborate the hypotheses proposed to strengthen this knowledge and determine the characteristics that predominate in pulmonary injury due to SARS-CoV-2 infection in pediatrics.(AU)

Characterization of signals for a Divertor Tokamak Test facility interferometer/polarimeter system.

In magnetically confined fusion experiments, laser interferometer/polarimeter systems allow one to determine plasma density, give valuable information on the internal magnetic fields, and contribute to the evaluation of the plasma magnetic equilibrium and to the real-time estimation of the q profile to allow feedback configuration control. This work presents an analysis of the interferometric and polarimetric signals of a multi-chord far-infrared interferometer/polarimeter for the divertor tokamak test facility, the new tokamak device currently under construction in Italy. The polarimetric signals are calculated both with approximate formulas and by solving the equation describing the evolution of the laser beam polarization inside the plasma using the Mueller formalism. The latter method correctly accounts for crosstalk between Faraday rotation and the Cotton-Mouton effect. The impact of the plasma birefringence on the interferometric phase shift is also studied, and it is found that a perturbation of the interferometric phase shift is present also in the case of an initial fixed linear polarization of the probe laser beam.

Performance analysis of two immunochromatographic assays for the diagnosis of rotavirus infection.

Group A rotaviruses (RVAs) are the primary cause of acute gastroenteritis (AGE) in young children worldwide. Several commercial tests including latex agglutination, enzyme-linked assays (ELISA) and immunochromatographic tests (ICT) have been developed for the diagnosis of RVA infection. In the present study, the performance of two commercially available one-step chromatographic immunoassays, CerTest Rotavirus+Adenovirus (Biotec S.L, Zaragoza, Spain) and Vikia Rota-Adeno (bioMerieux SA, Lyon, France) were retrospectively evaluated using Real-time PCR as reference test. Re-testing by Real-time PCR of 2096 stool samples of children hospitalized with AGE previously screened by ICTs (1467 by CerTest and 629 by Vikia) allowed to calculate higher sensitivity for Vikia (94% vs 85% of CerTest) and higher specificity for CerTest (93% vs 89% of Vikia). Accordingly, higher Positive Predictive Values (87% vs 78%) and Positive Likelihood Ratios (12.32 vs 8.8) were found for CerTest and lower Negative Predictive Values (91% vs 97%) and Negative Likelihood Ratios (0.16 vs 0.06) for Vikia. However, both CerTest and Vikia showed a substantial agreement (κ=0.79) with the Real-time PCR. A correlation between false negative results by ICTs and high Cycle Threshold values of Real-time PCR, indicative of low viral load, was observed. False positive results by the two ICT assays were not related to Norovirus, Adenovirus or Astrovirus infections, therefore the risk of cross-reactions was excluded. Both CerTest and VIKIA were able to detect the wide range of RVA genotypes circulating over the study period (including G1P[8], G2P[4], G3, G4, G9 and G12P[8]). The results of the present study showed a satisfactory efficacy of the two diagnostic tests analyzed.

Internal Transport Barrier Broadening through Subdominant Mode Stabilization in Reversed Field Pinch Plasmas.

The reversed field pinch (RFP) device RFX-mod features strong internal transport barriers when the plasma accesses states with a single dominant helicity. Such transport barriers enclose a hot helical region with high confinement whose amplitude may vary from a tiny one to an amplitude encompassing an appreciable fraction of the available volume. The transition from narrow to wide thermal structures has been ascribed so far to the transport reduction that occurs when the dominant mode separatrix, which is a preferred location for the onset of stochastic field lines, disappears. In this Letter we show instead that the contribution from the separatrix disappearance, by itself, is marginal and the main role is instead played by the progressive stabilization of secondary modes. The position and the width of the stochastic boundary encompassing the thermal structures have been estimated by applying the concept of a 3D quasiseparatrix layer, developed in solar physics to treat reconnection phenomena without true separatrices and novel to toroidal laboratory plasmas. Considering the favorable scaling of secondary modes with the Lundquist number, these results open promising scenarios for RFP plasmas at temperatures higher than the presently achieved ones, where lower secondary modes and, consequently, larger thermal structures are expected. Furthermore, this first application of the quasiseparatrix layer to a toroidal plasma indicates that such a concept is ubiquitous in magnetic reconnection, independent of the system geometry under investigation.

Introduction and prolonged circulation of G12 rotaviruses in Sicily.

Genotype G12 strains are now considered to be the sixth most prevalent human rotaviruses worldwide. In two Sicilian cities, Palermo and Messina, surveillance of rotavirus circulation performed since 1985 and 2009, respectively, did not detect G12 strains until 2012. From 2012 to 2014 rotavirus infection was detected in 29·7% of 1647 stool samples collected from children admitted for acute gastroenteritis to three Sicilian hospitals in Palermo, Messina and Ragusa. In 2012, G12P[8] was first detected in Palermo and then in Messina where it represented the second most frequent genotype (20% prevalence) after G1P[8]. Thereafter, G12 strains continued to circulate in Sicily, showing a marked prevalence in Ragusa (27·8%) in 2013 and in Palermo (21%) and Messina (16·6%) in 2014. All but one of the Sicilian G12 strains carried a P[8] VP4 genotype, whereas the single non-P[8] rotavirus strain was genotyped as G12P[9]. Phylogenetic analysis of the VP7 and VP4 sequences allowed distinction of several genetic lineages and separation of the G12P[8] strains into three cluster combinations. These findings indicate independent introductions of G12 rotavirus strains in Sicily in recent years.

Minimally constrained model of self-organized helical states in reversed-field pinches.

We show that the self-organized single-helical-axis (SHAx) and double-axis (DAx) states in reversed field pinches can be reproduced in a minimally constrained equilibrium model using only five parameters. This is a significant reduction on previous representations of the SHAx which have required an infinite number of constraints. The DAx state, which has a nontrivial topology, has not previously been reproduced using an equilibrium model that preserves this topological structure. We show that both states are a consequence of transport barrier formation in the plasma core, in agreement with experimental results. We take the limit of zero pressure in this work, although the model is also valid for finite pressure.

Vanishing magnetic shear and electron transport barriers in the RFX-mod reversed field pinch.

We define the safety factor q for the helical plasmas of the experiment RFX-mod by accounting for the actual three-dimensional nature of the magnetic flux surfaces. Such a profile is not monotonic but goes through a maximum located in the vicinity of the electron transport barriers measured by a high resolution Thomson scattering diagnostic. Helical states with a single axis obtained in viscoresistive magnetohydrodynamic numerical simulations exhibit similar nonmonotonic q profiles provided that the final states are preceded by a magnetic island phase, like in the experiment.

Bifurcation to 3D helical magnetic equilibrium in an axisymmetric toroidal device.

We report the first direct measurement of the internal magnetic field structure associated with a 3D helical equilibrium generated spontaneously in the core of an axisymmetric toroidal plasma containment device. Magnetohydrodynamic equilibrium bifurcation occurs in a reversed-field pinch when the innermost resonant magnetic perturbation grows to a large amplitude, reaching up to 8% of the mean field strength. Magnetic topology evolution is determined by measuring the Faraday effect, revealing that, as the perturbation grows, toroidal symmetry is broken and a helical equilibrium is established.

Single-helical-axis states in reversed-field-pinch plasmas.

The transition to a new magnetic topology, characterized by a quasi-single-helicity state with a single helical magnetic axis has been experimentally observed for the first time in a reversed-field-pinch plasma. The occurrence of the new state, which has been dubbed a single-helical-axis state, was found to provide magnetic chaos healing and enhanced thermal content of the plasma. The helical structure extends on both sides of the vessel geometric axis, and is related to exceeding a threshold in the ratio between the amplitude of the dominant MHD mode and the amplitude of the secondary ones.

Enhanced confinement and quasi-single-helicity regimes induced by poloidal current drive.

Enhanced confinement regimes with quasihelical symmetry are reproducibly obtained in the modified reversed field pinch eXperiment (RFX)-mod by reducing the level of internal chaos through the combination of a smooth magnetic boundary (through a virtual shell scheme) and the oscillating poloidal current drive technique. The plasma moves from a chaotic multiple helicity towards a quasi-single-helicity regime with a magnetic island showing high temperature and soft x-ray emissivity. The chaos reduction involves also the plasma outside the island allowing for a global enhanced confinement with an improvement up to 50%.

Active-feedback control of the magnetic boundary for magnetohydrodynamic stabilization of a fusion plasma.

Stable operation with control on magnetohydrodynamic modes has been obtained in the modified reversed field experiment employing a set of 192 feedback controlled saddle coils. Improvements of plasma temperature, confinement (twofold), and pulse length (threefold) and, as a consequence of the magnetic fluctuation reduction, strong mitigation of plasma-wall interaction and mode locking are reported.

Quasistationary magnetic fluctuation control in the reversed field pinch: a proof of principle experiment.

We present the results of the first successful experiments aimed to control in a quasistationary way the magnetic fluctuation dynamics in a reversed field pinch (RFP) device. This is done by the application of an oscillating poloidal electric field to the plasma edge. Although the additional power input is negligible, a stationary positive effect on the electron temperature is obtained. Temperature increases up to 50% over the standard values. This experiment demonstrates that in principle a stationary current profile and magnetic fluctuation control technique is feasible in the RFP.