Comparative performance of machine learning models for the classification of human gait.

The efficacy of human activity recognition (HAR) models mostly relies on the characteristics derived from domain expertise. The input of the classification algorithm consists of many characteristics that are utilized to accurately and effectively classify human physical activities. In contemporary research, machine learning techniques have been increasingly employed to automatically extract characteristics from unprocessed sensory input to develop models for Human Activity Recognition (HAR) and classify various activities. The primary objective of this research is to compare and contrast several machine learning models and determine a reliable and precise classification model for classifying activities. This study does a comparison analysis in order to assess the efficacy of 10 distinct machine learning models using frequently used datasets in the field of HAR. In this work, three benchmark public human walking datasets are being used. The research is conducted based on eight evaluating parameters. Based on the study conducted, it was seen that the machine learning classification models Random Forest, Extra Tree, and Light Gradient Boosting Machine had superior performance in all the eight evaluating parameters compared to specific datasets. Consequently, it can be inferred that machine learning significantly enhances performance within the area of Human Activity Recognition (HAR). This study can be utilized to provide suitable model selection for HAR-based datasets. Furthermore, this research can be utilized to facilitate the identification of various walking patterns for bipedal robotic systems.

Impact of environment and LULC changes on groundwater resources in the Soan Basin, western Himalaya.

The present study assesses the environmental and Land Use Landcover (LULC) changes in the Soan Basin, western Himalaya between 1999 and 2015 and their impacts on groundwater quality and static water level (SWL). An increase in the area of agricultural land (19%), settlement (~ 300%), and dense forest (25%) at the expense of open forest and waste cum grazing land was observed subsequently since the year 1999. SWL was lowered in the basin between 1999 and 2013 due to less groundwater recharge with decreased permeable surfaces and decreased rainfall, except in a few locations in the valley fill region plausibly due to the secondary recharge through seepages, infiltration of irrigational wastewater, and waterlogging in the agricultural fields. A continuous lowering of SWL after 2015, even after increasing the rain amount significantly, indicates overexploitation of groundwater in the region. Enhanced use of fertilizers has resulted in an increased concentration of Na+ and Cl- ions in groundwater. The results are further substantiated by comparing the hydrochemical data for the years 1999 and 2015, which again indicate the high concentration of Na+ and Cl- ions due to waterlogging. From 1999 to 2015, nitrate (average 12.8 mg/l to 16 mg/l) and fluoride concentration (average 0.3 to 0.9) have also increased because of the excessive use of fertilizers in the agricultural fields. The increasing trend of nitrate concentrations in water in successive years since 1994 supports the changes observed in an agricultural pattern in LULC maps for the years 1999, 2009, and 2015. The results divulge that the groundwater quality of the basin has been deteriorating due to an increase in agricultural practices and demands for appropriate water management practices.

Delivering therapeutic cannabinoids via skin: Current state and future perspectives.

Adequate evidence exists in the literature indicating a relatively positive shift with regards to the legal acceptance of cannabis and cannabis-derived products for medicinal purposes in some countries. Concomitantly, scientists are showing renewed interest in cannabis-related research work. Over the years, clinical and preclinical studies have demonstrated the therapeutic significance of cannabinoids for diverse indications. Additionally, efforts are being made to develop cannabis-related products into acceptable prescription products. FDA authorization for the commercial use of four cannabinoid-derived products, available as oral dosage forms is a significant progress already. However, there are certain drawbacks associated with the conventional delivery forms of cannabinoids. These include low oral bioavailability due to hepatic degradation, gastric instability, poor water solubility, and the side effects experienced upon the use of high doses of psychotropic cannabinoids associated with heightened plasma concentrations of the drug. These are however, limitable with the aid of transcutaneous drug delivery. Emerging topical and transdermal strategies could be exploited for the successful development of highly effective delivery systems for cannabinoids. This review discusses the feasibility of delivering therapeutic cannabinoids via skin and provides a comprehensive account of the supporting research studies that have been reported in the literature till date.

Therapeutic Potential of Essential Oil-based Microemulsions: Reviewing State-of-the-art.

A pre-eminent emulsion-based micellar drug delivery system, "microemulsion", comprising drug in oil or water phase, stabilized by surfactants and co-surfactants, has been evidenced to have a phenomenal role in a number of applications. Oils play an important role in the formation of ME and increase the drug absorption at the site of action. Oils employed in microemulsion formulation solubilize lipophilic drug. As the concept of "natural" therapies is recently gaining importance amongst researchers all over the world, scientists are employing essential oil as an organic component in this system. The active components of essential oils include flavonoids, phenylpropanoids, monoterpenes and polyunsaturated mega-6-fatty acids. These oils are enriched with characteristic intrinsic properties such as anti-oxidant, anti-bacterial, anti-viral, etc., bestowing enhanced supremacy to the whole microemulsion system. This mini-review is the first to document various types of essential oils employed in microemulsion systems and highlight their therapeutic potential and applications as drug delivery vehicles. Key inferences from this study suggest: 1) Clove oil is the most explored oil for incorporation into a microemulsion based system, followed by peppermint and Tea Tree Oil (TTO). 2) Penetration enhancing effects of these oils are due to the presence of terpenic constituents. 3) Essential oil based microemulsions protect volatility of ethereal oils and protect them from degradation in the presence of light, air, temperature. 4) These systems may also be explored for their applications in different industries like aromatherapy, food, drink, fragrance, flavour, cosmeceutical, soap, petroleum and pharmaceutical industry.

Treatment Modalities of Psoriasis: A Focus on Requisite for Topical Nanocarrier.

BACKGROUND AND OBJECTIVE: Psoriasis is an autoimmune skin disease involving cascading release of cytokines activated by the innate and acquired immune system. The increasing prevalence rate of psoriasis demands for more appropriate therapy. The existing chemical moiety is promising for better therapeutic outcome, but the selection of a proper channel for administration has to be reviewed. Hence there is a need to select the most appropriate dosage form and route of administration for improving the curative rate of psoriasis. RESULTS: A total of 108 systematic reviews of research and review articles were conducted to make the manuscript comprehensible. The role of inflammatory mediators in the pathogenesis of the disease is discussed for a better understanding of the selection of pharmacotherapy. The older and newer therapeutic moiety with its mode of administration for psoriasis treatment has been discussed. With a comparative review on topical and oral administration of first-line drugs such as methotrexate (MTX), cyclosporine (CsA), and betamethasone, its benefits-liabilities in the selected routes were accounted for. Emphasis has also been paid on advanced nanocarriers for dermatologic applications. CONCLUSION: For a better therapeutic outcome, proper selection of drug moiety with its appropriate administration is the major requisite. With the advent of nanotechnology, the development of nanocarrier for dermatologic application has been successfully demonstrated in positioning the systemically administrated drug into topical targeted delivery. In a nutshell, to achieve successful treatment strategies towards psoriasis, there is a need to focus on the development of stable, non-toxic nanocarrier for topical delivery. Inclusion of the existing orally administered drug moiety into nanocarriers for topical delivery is proposed in order to enhance therapeutics payload with reduced side effects which serves as a better treatment approach for relief of the psoriasis condition.

Intracranial Tumors: A Nurse-Led Intervention for Educating and Supporting Patients and Their Caregivers

BACKGROUND: Behavioral symptoms among postoperative patients with intracranial tumors and distress among caregivers are common. OBJECTIVES: This article aimed to assess the effectiveness of a brief nurse-led intervention on behavioral symptoms of postoperative patients with intracranial tumors and distress of their caregivers. METHODS: A randomized controlled trial was conducted on 80 patients with intracranial tumors and their family caregivers in a tertiary care institute in India. A brief nurse-led intervention was provided in the form of individual counseling, and a pamphlet was given to patients and caregivers in the experimental group at the time of discharge. Behavioral symptoms of patients and distress of caregivers were assessed. FINDINGS: Patients in the experimental group had significantly fewer behavioral symptoms and less severity of behavioral symptoms as compared to the control group. Caregivers in the experimental group had significantly less severity of distress as compared to the control group.

Hybrid optimal control for HIV multi-drug therapies: a finite set control transcription approach.

In this study, the treatment of Human Immunodeficiency Virus (HIV) infection is investigated through an optimal structured treatment interruption (STI) schedule of two classes of antiretroviral drugs, mainly, reverse transcriptase inhibitors and protease inhibitors. An STI treatment strategy may be beneficial in lowering the risk of HIV mutating to drug-resistant strains, and could provide patients with respite from toxic side effects of HAART. A shorter treatment period is considered compared to previous studies and the solution to the HIV STI problem is obtained via the Finite Set Control Transcription (FSCT) formulation. The FSCT formulation offers a unique approach for handling multiple independent decision variables simultaneously, and, as is shown by the results of this study, is well-suited for an effective treatment of the optimal STI problem. The results obtained in the present investigation demonstrate that immune boosting and subsequent natural suppression of the viral load are possible even when a reduced STI therapy treatment duration is in consideration.