Assuntos
Delírio de Parasitose/psicologia , Dermoscopia/métodos , Esquizofrenia Paranoide/psicologia , Pele/patologia , Acanthamoeba/parasitologia , Antipsicóticos/uso terapêutico , Benzodiazepinas/administração & dosagem , Benzodiazepinas/uso terapêutico , Delírio de Parasitose/tratamento farmacológico , Delírio de Parasitose/parasitologia , Humanos , Masculino , Pessoa de Meia-Idade , Olanzapina , Relações Médico-Paciente , Prurigo/patologia , Esquizofrenia Paranoide/complicações , Resultado do TratamentoAssuntos
Deficiência Intelectual/psicologia , Memória , Adulto , Humanos , Masculino , Testes PsicológicosAssuntos
Depressão/psicologia , Privação do Sono , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-IdadeAssuntos
Ansiolíticos/uso terapêutico , Transtornos de Ansiedade/tratamento farmacológico , Diazepam/uso terapêutico , Ansiedade/fisiopatologia , Ensaios Clínicos como Assunto , Humanos , Destreza Motora/efeitos dos fármacos , Escalas de Graduação Psiquiátrica , Transtornos do Sono-Vigília/tratamento farmacológicoRESUMO
Clobazam, a new antianxiety compound, was compared in a double-blind study with diazepam in 40 neurotic outpatients. Twenty-three patients completed the trial under clobazam conditions while 17 patients completed the trial under diazepam conditions. The trial was conducted for a period of four weeks of active drug administration followed by a one-week period of placebo administration. Clobazam was administered in three divided doses of 30 to 40 mg/day, while diazepam was administered in three divided doses of 15 to 20 mg/day, following a fixed dosage schedule. No significant differences were noted between the two treatment conditions during the drug trial period. The patients on clobazam maintained greater improvement during the placebo trial period for the variables "somatic anxiety" and "nights of sleep disturbance." Simultaneous motor coordination tests (hand steadiness test) showed greater improvement on clobazam throughout the trial period in patients with an initial error score greater than 50 points. This difference was significant during the second week of the trial.