An unusual presentation of a sarcoidosis that mimicked lymphatic metastatize non small cell lung carcinoma in positron emission tomography: a case report.

In the last decade, several sophisticated and accurate imaging methods such as positron emission tomography have been developed in order to evaluate malignant potential in enlarged mediastinal lymph nodes. This case illustrates an unusual presentation of sarcoidosis that mimicked lymphatic metastases of non small cell lung carcinoma. The reported high specificity and sensitivity of positron emission tomography-Computer Tomography regarding mediastinal staging could lead in same cases of false positives to a delaying of stage adapted therapy of non small cell lung carcinoma, showing that despite the recent advances of imaging techniques, such as positron emission tomography-computer tomography, several limitations of this imaging technique are still existing.

Antegrade cerebral perfusion for acute type A aortic dissection in 120 consecutive patients.

BACKGROUND: Treatment of acute type A aortic dissection remains a surgical challenge because of prolonged operative times, bleeding complications, and a considerable risk of neurologic morbidity and mortality. The following study investigates clinical results after modification of perfusion technique for cardiopulmonary bypass as well as temperature management. METHODS: Between January 2000 and August 2006, 120 consecutive patients underwent repair of acute type A dissection. Selective antegrade cerebral perfusion through the right subclavian artery combined with mild systemic hypothermia (30 degrees C) was used in all patients. RESULTS: Mean cardiopulmonary bypass time was 144 +/- 53 minutes, and mean myocardial ischemic time was 98 +/- 49 minutes. Isolated cerebral perfusion was performed for 25 +/- 12 minutes. Mean core temperature amounted to 30.1 degrees +/- 2.2 degrees C. Chest tube drainage during the first 24 hours was 525 +/- 220 mL. Mean ventilation time was 54 +/- 22 hours. Elevation of serum lactate levels at 1, 12, and 24 hours postoperatively rose to 22 +/- 14, 18 +/- 11, and 19 +/- 8 mg/dL respectively. We observed new postoperative permanent neurologic deficits in 5 patients (4.2%) and TND in 3 patients (2.5%). The 30-day mortality rate was 5% (n = 6). After a mean follow-up period of 2.8 years, 104 patients (87%) were still alive. CONCLUSIONS: Antegrade cerebral perfusion in combination with mild hypothermia offered sufficient neurologic protection in our patient cohort, provided adequate distal organ protection, and reduced perioperative complications in surgery for type A dissection. This perfusion strategy may help in reducing perioperative complications in this particular patient population.

Value of cerebral perfusion computed tomography in the management of intensive care unit patients with suspected ischaemic cerebral pathology after cardiac surgery.

OBJECTIVE: Adverse neurologic outcomes, like stroke, in intensive care unit (ICU) patients after cardiac surgery can have devastating consequences, among them increased mortality risk and, among survivors, loss of independence and a diminished quality of life. Non-contrast computed tomography (CT) remains a widely utilised modality for assessing stroke; however, it has a low sensitivity in the acute phase. Perfusion CT (PCT) has the potential of imaging stroke in its hyperacute phase. We evaluated the feasibility and results of the method among patients from the ICU. METHODS: The NCCT and PCT images of 33 retrospectively identified patients were included in this study. The diagnostic contribution of the PCT to patient management was classified according to one of three categories: (A) those that changed the preliminary (NCCT) diagnosis; (B) those that revealed additional pathology and/or specified more exactly findings that have been detected by NCCT or clinically suspected; and (C) confirmed the preliminary diagnosis. Neurologic outcome variables were also documented and associated with PCT lesions. RESULTS: Fifteen patients after coronary artery bypass graft (CABG) operation, 14 patients after CABG and valve surgery, and 4 patients after an aortic dissection (Type A) surgery underwent a NCCT with PCT 2.4+/-1.3 days after the operation. Twenty patients had bilateral internal carotid artery (ICA) stenosis (>50%), 11 patients had unilateral ICA stenosis (>75%), and 2 patients had no ICA stenosis. In nine patients (27.2%) the PCT changed the initial diagnosis of the NCCT and revealed ischaemic pathology. In 24 patients (72.7%), the performed PCT revealed additional pathology and/or more completely characterised findings that have been detected by the initial NCCT. In nine patients, PCT confirmed only the initial diagnosis. Patients with normal PCT findings had a favourable outcome; patients with large lesions in PCT in one or more vascular territories had an unfavourable outcome; seven patients with lesions in basal ganglia and/or semioval centre had a favourable outcome. CONCLUSIONS: PCT shows a greater sensitivity in detecting and mapping acute ischaemic stroke in ICU patients (after cardiac surgery) in whom conventional imaging findings are not in line with the severity of the clinical condition.

Impact of high thoracic epidural anesthesia on incidence of perioperative atrial fibrillation in off-pump coronary bypass grafting: a prospective randomized study.

OBJECTIVE: Atrial fibrillation is one of the most common complications in patients undergoing coronary artery bypass grafting. The goal of this study was to investigate the impact of high thoracic epidural anesthesia on reduction of perioperative arrhythmia in patients undergoing off-pump coronary artery bypass grafting. METHODS: We prospectively randomized 132 patients undergoing elective off-pump coronary bypass grafting using either general anesthesia (GA) (n = 66) or combined general and high thoracic epidural anesthesia (GA+TEA) (n = 66). Incidence of perioperative arrhythmias such as atrial fibrillation, serum epinephrine levels, heart rate variability, and hemodynamic parameters were compared between groups. RESULTS: The incidence of perioperative dysarrhythmias was significantly lower (P < .01) in the GA+TEA group (3%) than in the GA group (23.7%). Intraoperative sinus bradycardia occurred in 91% of the patients in the GA+TEA group versus 5.3% in the GA group. After induction of anesthesia, the mean systolic arterial pressure decreased significantly from 128 +/- 5 to 92 +/- 4 mm Hg and the heart rate from 74 +/- 9 to 52 +/- 8 beats . min(-1) in the GA+TEA group, whereas in the GA group no significant hemodynamic changes were observed (P < .001). Serum epinephrine levels were significantly lower in the GA+TEA group (69 +/- 11 to 35 +/- 7 ng/dL) than in the GA group (72 +/- 9 to 70 +/- 9 ng/dL). CONCLUSIONS: In our study cohort, high thoracic epidural anesthesia in combination with general anesthesia reduced significantly the incidence of perioperative arrhythmias such as atrial fibrillation. Furthermore, we observed a significant reduction of epinephrine serum levels in this patient group. The results of this study support a combination of general anesthesia with thoracic epidural anesthesia as a multidisciplinary approach, which may lead to a better patient outcome, improvement of early analgesia, and reduction of perioperative complications in off-pump coronary artery bypass procedures. The potential risks of thoracic epidural anesthesia during off-pump coronary artery bypass procedures should not be underestimated.

Impact of left atrial size reduction and endocardial radiofrequency ablation on continuous atrial fibrillation in patients undergoing concomitant cardiac surgery: three-year results.

BACKGROUND AND AIM OF THE STUDY: The study aim was to evaluate the efficacy of left atrial (LA) size reduction combined with radiofrequency (RF) ablation in the treatment of continuous atrial fibrillation (AF), by comparative analysis of the outcomes of patients undergoing RF ablation with and without LA size reduction. METHODS: A total of 46 patients with continuous AF and cardiac disease underwent cardiac surgery and RF ablation alone (group I, n = 20) or combined with LA size reduction (group II, n = 26). Patients were followed for three years postoperatively, with evaluation of cardiac rhythm, neurological complications, LA size (by echocardiography) and atrial contractility. RESULTS: At three years after surgery, sinus rhythm (SR) was restored in 61.1% and 70% of patients in groups I and II, respectively. Mean LA diameter was reduced from 60 +/- 15 mm to 57 +/- 5 mm in group I, and from 69 +/- 19 mm to 55 +/- 6 mm in group II. The overall three-year survival was 90% in group I, and 88.5% in group II. Three-year freedom from stroke was 88.9% and 86.2% in groups I and II, respectively. Two patients in each group received transvenous permanent pacemaker implantation. Atrial contractility was recovered in all patients with stable SR. CONCLUSION: LA size reduction improves SR conversion rate after RF ablation for continuous AF in patients undergoing concomitant cardiac surgery.