Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 1 de 1
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
1.
Acta Neuropsychiatr ; 32(6): 321-327, 2020 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-32660670

RESUMO

OBJECTIVE: To evaluate the involvement of nod-like receptor pyrin domain-containing protein 3 (NLRP3) inflammasome in schizophrenia-like behaviour in young animals exposed to maternal immune activation (MIA). METHODS: To this aim, on the 15th gestational day, the females received an injection of lipopolysaccharides. When the animals completed 7, 14 and 45 postnatal days, they were killed and the whole brain was dissected for biochemical analysis. Animals with 45 postnatal days were submitted to behavioural tests of locomotor activity, social interaction and stereotyped movements. RESULTS: It was observed that the animals presented schizophrenia-like behaviour at 45 postnatal days associated with the increase of NLRP3 inflammasome expression and IL-1ß levels on 7, 14 and 45 postnatal days. CONCLUSION: This study shows that MIA may be associated with a schizophrenia-like behaviour. This behaviour can be induced to a neuroinflammatory profile in the brain. These evidences may base future studies on the relationship between neuroinflammation and psychiatric disorders.


Assuntos
Animais Recém-Nascidos/psicologia , Inflamassomos/metabolismo , Interleucina-1beta/metabolismo , Proteína 3 que Contém Domínio de Pirina da Família NLR/metabolismo , Esquizofrenia/diagnóstico , Animais , Animais Recém-Nascidos/metabolismo , Escala de Avaliação Comportamental/normas , Encéfalo/metabolismo , Feminino , Idade Gestacional , Comportamento de Doença/fisiologia , Imunidade Ativa/efeitos dos fármacos , Inflamassomos/imunologia , Injeções Intraperitoneais , Lipopolissacarídeos/administração & dosagem , Lipopolissacarídeos/efeitos adversos , Masculino , Camundongos , Camundongos Endogâmicos C57BL , Mães , Transtornos Neurocognitivos/imunologia , Esquizofrenia/sangue
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA