[Polymorphic markers G(-455)A of gene FGB and C(-1654)T of gene PROC and genetic predisposition to unfavorable outcomes patients undergoing acute coronary syndrome].

We investigated the association of polymorphisms of genes FGB G(-455)A and PROCC(-1654)T with coronary artery disease (CAD) in the Russian population. A total of 1145 patients with CAD diagnose on the basis of clinical studies in cardiological hospitals of Moscow, St. Petersburg, Kazan, Chelyabinsk, Perm, Stavropol and Rostov-on-Don. Supervision term was 1.14 +/- +/- 0.33 years (the maximum term 3.2 years). The group studied do not differ significantly with respect to the distributions of G(-455)A alleles and genotypes. However in case of gene PROC C(-1654)T polymorphism we determined that patients with CAD diagnose and Talleles of PROC gene had unfavorable outcome more often than patients with homozygous C alleles. Survival time from end point from carrier phenotype TT and CTis 2.19 +/- 0.18 r. years against 2.46 +/- 0.16 from carrier phenotype CCgene PROC. The obtained data allows to assume the important role of the genes which are responsible for functioning of system of a hemostasis, in the accelerated formation of failures at the patients who had a coronary syndrome.

[Effect of the sympathetic nervous system on local physical and chemical mechanisms of regulating circulation in skeletal muscles]. / Vliianie simpaticheskoi nervnoi sistemy na mestnye fizicheskie i khimicheskie mekhanizmy reguliatsii krovoobrashcheniia v skeletnykh myshtsakh.

In healthy subjects and in patients with beginning hypertension the blood flow in the forearm muscles was studied in resting as well as in hyperemia induced with excitation of the sympathetic nervous system. The blood flow and the hyperemia proved to be considerably smaller in the patients whereas the blood flow in mental stress was much greater in them as compared to healthy subjects. In emotional stress, the hyperemia considerably decreased in healthy subjects. In maximal vasodilatation induced with cessation of blood flow in limbs, the reflex vasoconstrictory responses were preserved. The data obtained suggest sympathetic influences upon the induced hyperemia and deny the phenomenon of functional sympatholysis.