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Avian Dis ; 59(4): 518-24, 2015 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-26629626

RESUMO

Inclusion body hepatitis (IBH) is one of the major infectious diseases adversely affecting the poultry industry of the United States and Canada. Currently, no effective and safe vaccine is available for the control of IBH virus (IBHV) infection in chickens. However, based on the excellent safety and immunogenic profiles of experimental veterinary vaccines developed with the use of new generation adjuvants, we hypothesized that characterization of vaccine formulations containing inactivated IBHV or its capsid protein hexon as antigens, along with poly[di(sodium carboxylatoethylphenoxy)phosphazene] (PCEP) and avian beta defensin 2 (ABD2) as vaccine adjuvants, will be helpful in development of an effective and safe vaccine formulation for IBH. Our data demonstrated that experimental administration of vaccine formulations containing inactivated IBHV and a mixture of PCEP with or without ABD2 as an adjuvant induced significantly higher antibody responses compared with other vaccine formulations, while hexon protein-based vaccine formulations showed relatively lower levels of antibody responses. Thus, a vaccine formulation containing inactivated IBHV with PCEP or a mixture of PCEP and ABD2 (with a reduced dosage of PCEP) as an adjuvant may serve as a potential vaccine candidate. However, in order to overcome the risks associated with whole virus inactivated vaccines, characterization of additional viral capsid proteins, including fiber protein and penton of IBHV along with hexon protein in combination with more new generation adjuvants, will be helpful in further improvements of vaccines against IBHV infection.


Assuntos
Infecções por Adenoviridae/prevenção & controle , Vacinas contra Adenovirus/imunologia , Adjuvantes Imunológicos/administração & dosagem , Galinhas , Adenovirus A das Aves/imunologia , Hepatite Animal/prevenção & controle , Doenças das Aves Domésticas/prevenção & controle , Vacinas contra Hepatite Viral/imunologia , Infecções por Adenoviridae/virologia , Vacinas contra Adenovirus/administração & dosagem , Animais , Proteínas do Capsídeo/administração & dosagem , Proteínas do Capsídeo/imunologia , Vírus de Hepatite/imunologia , Hepatite Animal/virologia , Imunidade Inata , Fenilpropionatos/administração & dosagem , Fenilpropionatos/imunologia , Polímeros/administração & dosagem , Doenças das Aves Domésticas/virologia , Proteínas Recombinantes/administração & dosagem , Proteínas Recombinantes/imunologia , Vacinas de Produtos Inativados/administração & dosagem , Vacinas de Produtos Inativados/imunologia , Vacinas contra Hepatite Viral/administração & dosagem , beta-Defensinas/administração & dosagem , beta-Defensinas/imunologia
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