One- and Two-Coordinate Detectors in BINP.

One- and two-coordinate detectors with proportional chambers developed at the Budker Institute of Nuclear Physics (BINP) are presented. The parallax-free 10 MHz one-coordinate OD-3.1 and OD-3.2 detectors are used in synchrotron radiation powder diffraction and SAXS experiments. The two-coordinate DED-3 detector with a multiwire proportional chamber (MWPC) is used in Laue diffraction. The latest modification of this detector, DED-5, with a working area of 384 x 384 mm, is briefly described. The micro-strip detector prototype MSGC-100 has passed test synchrotron radiation experiments and the next modification (MSGC-500), with 500 channels for high energy, is under construction. The one-coordinate MWPC OD-160 detector, with an angle aperture of 160 degrees and a count rate of 3.3 GHz, is under construction. It will be used for high-resolution powder diffraction. Two types of gas chamber will be used: L for low energies (5-30 keV) and H for high energies (30-70 keV). A 16 degrees section with an H-chamber has been produced and tested on the synchrotron radiation beamline.

Synthesis and immunological evaluation of the conjugates composed from a muramyl peptide GMDP and tuftsin.

The conjugates of a muramyl dipeptide analog GMDP (N-acetylglucosaminyl beta 1-->4 N-acetylmuramyl-L-alanyl-D-isoglutamine) and tuftsin (Thr-Lys-Pro-Arg) were synthesized from unprotected GMDP by mixed anhydride procedure. The identity of the conjugates was confirmed by high resolution NMR and their immunomodulating properties were determined in various tests. It was found that the conjugate in which the GMDP carboxyl group forms an amide bond with the epsilon-amino group of tuftsin lysyl residue exceeds GMDP in all the activities determined. Synergism of GMDP and tuftsin was found in phagocytosis stimulation assay.

[The significance of the specific sensitization of immunocytes in assessing the immune response in viral hepatitis B]. / Znachenie spetsificheskoi sensibilizatsii immunotsitov v otsenke immunnogo otveta pri virusnom gepatite B.

A study is presented of 235 patients with viral hepatitis and 35 patients with other diseases of the liver. The method of antigen-specific indirect rosette formation was used. Sensibilization of immunocytes to superficial B hepatitis virus antigen was revealed in 84% of patients with viral B hepatitis. The author established a dependence of the clinical course of viral B hepatitis on the character and time appearance of the specific reaction of immunocytes. The determination of specific sensibilization of immunocytes improves the diagnosis and possibilities of viral B hepatitis prognosis.