[Suppurative complications of chickenpox in children]. / Gnoinye oslozhneniia vetrianoi ospy u detei.

In 1979-1990 213 children with local (n = 155) and generalized (n = 58) purulent complications of chickenpox, developing on days 2-6 after the eruptions, underwent treatment. They occurred mostly in children aged from 12 months to 3 years. Treatment of local forms caused no difficulties and was successful in all cases. A very severe course was encountered in 25 children with the development of ligneous phlegmon and toxico-infectious shock; 6 of them died. The extent of the lesion in these cases included more than 10% of the skin surface. The treatment consisted in multiple incisions, the prescription of antibiotics in maximal doses, and immunostimulating and infusion therapy.

[Clinico-morphological comparison in children with infectious endocarditis]. / Kliniko-morfologicheskie sopostavlenii pri infektsionnom éndokardite u detei.

As many as 21 children suffering from infectious endocarditis (IE) were examined for the clinical and morphological picture of the disease. The patients' age ranged from 2 to 15 years. In 15 children, IE developed in association with different congenital diseases; in one patient, in the presence of rheumatic heart disease, and in 5 patients, in unaffected heart valves. The sectional material was examined in 19 cases whereas the operational material in 2 cases. Analysis of the data obtained has shown that early diagnosis of IE (primary and secondary) may not infrequently be fairly difficult, which is likely to result in the late administration of antibacterial therapy. In addition to the involvement of the valvular apparatus of the heart, the majority of the patients demonstrated the signs of focal myocarditis and postmyocarditic cardiosclerosis, which is one of the causes of the development of refractory heart insufficiency. IE children mostly die from heart insufficiency and thromboembolism.

[T and B components of the immune system in acute bronchopulmonary diseases in children with thymomegaly and without it]. / Pokazateli T- i B-zven'ev sistemy immuniteta pri ostrykh bronkho- legochnykh zabolevaniiakh u detei s timomegaliei i bez nee.

The immune status was estimated comprehensively and indicators of the level I and II tests of T and B components of the immunity system were defined in 120 children with thymomegaly (group I), in 30 children with unenlarged thymus (group II), and in 40 practically healthy children with unestablished size of the thymus, with a favourable family and personal disease history, who had never fallen ill before the immunologic examination (group III). The children belonging to groups I and II were examined at the acute disease period, during convalescence and clinical wellbeing. It has been established that during the acute bronchopulmonary disease, the group I and II children manifested the same regularities of immune response to the action of an antigenic stimulus. However, at the period of the clinical wellbeing, the group II children showed a higher lymphocytosis, impairment of the ratio of the T lymphocyte subpopulations, an increase of the EAC--RFC count, and a decline of the level of serum thymic factor. It is assumed that in the group I children, the system of immunologic defence is of weak safety within the first 3 years of life.

[Clinico-morphological changes in congenital carditis in children]. / Kliniko-morfologicheskie izmeneniia pri vrozhdennykh karditakh u detei.

The clinico-morphological alterations were analyzed in 6 deceased children with congenital carditis. Morbid anatomy examination demonstrated that all the patients had marked alterations on the part of the heart while 4 cases manifested associated injuries to the heart and to the brain. In half of the children, the disease had run its course in combination with immunodeficiency. In 2 cases, there was an etiological relationship between congenital carditis and intrauterine enterovirus Coxsackie infection which had been uneventful in pregnant mothers. In congenital carditis, the prognosis may be often unfavourable.

[Ultrasonic methods of diagnosing infectious endocarditis in children]. / U'ltrazvukovye metody issledovaniia v diagnostike infektsionnogo éndokardita u detei.

Ultrasound research methods were applied in 32 children with the clinical signs of infectious endocarditis (IE). The patients' age varied from 3 to 16 years. In 5 patients, IE turned out primary in the intact valves whereas in 27 patients, it superadded on different congenital heart disease. In 10 patients, IE had developed before surgical correction of the diseases and in 17, within different times after operation. The direct and indirect echo-signs of IE were delineated. The direct echo-signs included vegetations which were discovered in 22 out of the 32 patients. The indirect echo-signs included the signs of regurgitation in the externally unchanged or minimally changed cusps of the valves and blood drop at the level of the ventricles in connection with the defect reshunting in the interventricular septum. The data obtained are in good agreement with the clinical picture, surgical and morbid anatomy data.