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INTRODUCTION: Achieving success in root canal (RC) therapy relies on three key components: comprehensive cleaning of the canal, efficient disinfection, and proper filling of the canal space. The present study aimed to compare the efficacy of four obturation techniques: single cone (SC), GuttaCore (GC), cold lateral condensation (LC), and C Point system for RC filling of permanent teeth. MATERIALS AND METHODS: 76 extracted human mandibular first premolars were divided into four groups, with 19 teeth in each group (group A, obturation with SC technique; group B, obturation with GC; group C, obturation with LC; and group D, obturation with C Point system). The samples were marked at 4 mm and 8 mm from the root apex using a marker and calliper, sectioned horizontally, and analyzed under a stereomicroscope at 20x magnification. The mean percentage (%) of gutta-percha (GP)-filled area was compared using a two-way analysis of variance (ANOVA), followed by the Bonferroni post-hoc test. RESULTS: The mean percentage of GP-filled area at a distance of 4 mm from the apex was highest in group B (0.86±0.04; 95% CI: 0.845-0.881), followed by group D (0.70±0.07; 95% CI: 0.664-0.736), group A (0.61±0.05; 95% CI: 0.595-0.642), and least in group C (0.58±0.09; 95% CI: 0.543-0.627), and the difference was statistically significant (p≤0.05). The post-hoc pairwise comparison of groups at 4 mm revealed that there were statistically significant differences between group D and groups B, C, and A (p ≤ 0.001). The mean percentage of the GP area at a distance of 8 mm from the apex was highest in group B (0.81±0.10; 95% CI: 0.761-0.861), followed by group D (0.75±0.07; 95% CI: 0.725-0.792), group A (0.69±0.07; 95% CI: 0.658-0.729), and lowest in group C (0.65±0.10; 95% CI: 0.607-0.709), and this difference was statistically significant (p≤0.05). Post-hoc pairwise comparison of groups at 8 mm revealed that there was a statistically significant difference between groups D and C (p=0.006), whereas no statistically significant differences were noted between groups D and B (p=0.473). Furthermore, no statistically significant differences were noted between groups C and A at 4 mm and 8 mm (p>0.05). CONCLUSION: Obturation with the GC system provided the best results in terms of the percentage of GP-filled area at 4 mm. However, at 8 mm from the apical region, both the GC and C Point systems provided similar results.
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Introduction The phenomenon of coronavirus disease 2019 (COVID-19)-related candidiasis is gaining increased attention and acknowledgment as an integral component of the severe consequences of COVID-19. The aim of the present study was to assess the association between Candida albicans and COVID-19 in complete denture wearers. Materials and methods An observational study was conducted on 45 complete denture wearers, who were divided into three groups as follows: Group 1, 15 subjects with mild to moderate COVID-19 infection; Group 2, 15 subjects with severe COVID-19 infection; and Group 3, 15 subjects without COVID-19 infection. Mean colony forming units (CFU) were observed on agar plates containing Sabouraud dextrose in the salivary samples of the participants. Analysis of variance, followed by post-hoc analysis by Tukey's test, was used to compare CFU between the groups. Pearson's correlation coefficient was used to study the correlation between variables. Results The highest average colony-forming units of Candida albicans were observed in Group 2, followed by Group 1, compared to the control group, and a significant (p<0.001) difference was found. A weak positive correlation was found between the age of the patients and the duration of denture usage, as well as between age and the counts of Candida albicans in Groups 1 and 3. This correlation was more pronounced in Group 3. A strong positive correlation was observed in all groups between the Candida albicans count and the duration of denture usage by the patients. Conclusion The association between Candida albicans and denture wear was compounded by the presence of COVID-19. Consequently, the timely identification of Candida albicans infection in patients with COVID-19 is important to establish more efficacious approaches for antifungal treatment and prophylactic interventions.