Complete genome sequence of Imperialibacter roseus strain P4T.

Imperialibacter roseus strain P4T is a bacterial strain isolated from Permian groundwater. The complete genome of Imperialibacter roseus strain P4T was sequenced to reveal a single circular chromosome of 6,747,663 bp with a GC content of 46.5%.

Micrococcus spp. as a promising source for drug discovery: A review.

Historically, bacteria of the phylum, Actinobacteria have been a very prominent source of bioactive compounds for drug discovery. Among the actinobacterial genera, Micrococcus has not generally been prioritized in the search for novel drugs. The bacteria in this genus are known to have very small genomes (generally < 3 Mb). Actinobacteria with small genomes seldom contain the well-characterized biosynthetic gene clusters such as those encoding polyketide synthases and nonribosomal peptide synthetases that current genome mining algorithms are optimized to detect. Nevertheless, there are many reports of substantial pharmaceutically relevant bioactivity of Micrococcus extracts. On the other hand, there are remarkably few descriptions of fully characterized and structurally elucidated bioactive compounds from Micrococcus spp. This review provides a comprehensive summary of the bioactivity of Micrococcus spp. that encompasses antibacterial, antifungal, cytotoxic, antioxidant, and anti-inflammatory activities. This review uncovers the considerable biosynthetic potential of this genus and highlights the need for a re-examination of these bioactive strains, with a particular emphasis on marine isolates, because of their potent bioactivity and high potential for encoding unique molecular scaffolds.

Draft Genome Sequences of Three Sponge-Associated Actinomycetes Exhibiting Antimycobacterial Activity.

Marine actinomycetes (order Actinomycetales) are of interest as a promising source of pharmaceuticals. The genomes of three novel sponge-associated actinomycetes exhibiting antimycobacterial activity, Brevibacterium sp. strain XM4083, Micrococcus sp. strain R8502A1, and Micromonospora sp. strain XM-20-01, were sequenced in an effort to identify compounds responsible for growth-inhibiting activity.