[Somatic mutation of the V617F JAK2 gene in patients of the cardiovascular diseases].

The JAK2 V617F somatic mutation is one of the most frequent markers of CHIP (clonal hematopoiesis of indeterminate potential). CHIP is characterized by the presence of a myeloid cells clone in peripheral blood in the absence of the sufficient reasons to diagnose the hematologic disease. The CHIP is proposed as a potential independent risk factor for vascular pathology. The aim of this study is to identify carriers of JAK2 V617F mutation among patients admitted for planned hospitalization at the Federal Center of Cardiovascular Surgery of Krasnoyarsk. MATERIALS AND METHODS: The study included 930 venous blood samples. JAK2 V617F mutation was detected by using the allele - specific real time polymerase chain reaction. RESULTS: JAK2 V617F mutation was detected in 15 (1.6%) patients, but only two of them had blood cell count that could cause a hematological disease to be suspected. CONCLUSION: The inclusion of the JAK2 V617F mutation detection in the complex of laboratory tests of the cardiovascular patients can facilitate the timely identification of patients with increased thrombotic risk, as well as the timely diagnosis of myeloproliferative diseases.

Mechanisms for Strong Anisotropy of In-Plane g-Factors in Hole Based Quantum Point Contacts.

In-plane hole g factors measured in quantum point contacts based on p-type heterostructures strongly depend on the orientation of the magnetic field with respect to the electric current. This effect, first reported a decade ago and confirmed in a number of publications, has remained an open problem. In this work, we present systematic experimental studies to disentangle different mechanisms contributing to the effect and develop the theory which describes it successfully. We show that there is a new mechanism for the anisotropy related to the existence of an additional B_{+}k_{-}^{4}σ_{+} effective Zeeman interaction for holes, which is kinematically different from the standard single Zeeman term B_{-}k_{-}^{2}σ_{+} considered until now.

[Prognostication of course and treatment of peripancreatic infiltrate in patients, suffering an acute necrotic pancreatitis].

Results of treatment of 229 patients, suffering an acute necrotic pancreatitis, complicated by peripancreatic infiltrate, were analyzed. To all the patients antibiotic prophylaxis and antibiotic therapy were conducted. In 63 (27.5%) patients the methods of extracorporal hemocorrection were applied, and in 108 (47.1%)--the "four--catheters" rule (catheter for epidural anesthesia, installment of the feeding intestinal probe further than the Treitz ligament level, the central vein catheterization, the programmed laparocentesis). In 31 (13.5%) patients there were determined the activity of mononuclear phagocytes and production of ROS (the oxygen active forms) by them in peripheral blood with objective for the purulent-septic complications prognostication. In 14 (6.1%) patients purulent--septic complications have occurred, postoperative lethality was 21.4%, general lethality--3.4%.

Quantum interferential Y-junction switch.

We report the observation of the Fermi energy controlled redirection of the ballistic electron flow in a three-terminal system based on a small (100 nm) triangular quantum dot defined in a two-dimensional electron gas (2DEG). Measurement shows strong large-scale sign-changing oscillations of the partial conductance coefficient difference G(21) - G(23) on the gate voltage in zero magnetic field. Simple formulas and numerical simulation show that the effect can be explained by quantum interference and is associated with weak asymmetry of the dot or inequality of the ports connecting the dot to the 2DEG reservoirs. The effect may be strengthened by a weak perpendicular magnetic field. We also consider an additional three-terminal system in which the direction of the electron flow can be controlled by the voltage on the scanning gate microscopy (SGM) tip.

Boundary-mediated electron-electron interactions in quantum point contacts.

An unusual increase of the conductance with temperature is observed in clean quantum point contacts for conductances larger than 2(e2/h). At the same time, a positive magnetoresistance arises at high temperatures. A model accounting for electron-electron interactions mediated by boundaries (scattering on Friedel oscillations) qualitatively describes the observation. It is supported by a numerical simulation at zero magnetic field.

[Long-term survival of patients with carcinoma of the pancreas complicated by jaundice]. / Tryvale vyzhyvannia khvorykh na rak pidshlunkovoï zalozy, uskladnenyi zhovtianytseiu.

Over the period 1998-2001 a total of 78 patients with III to IV stage carcinoma of the pancreas complicated by jaundice underwent symptomatic and palliative operations. In all patients, the diagnosis was verified histologically with the aid of intraoperative fine-needle biopsy, incision biopsy or in the postoperative period marked by appearance of metastases in the liver--by progressive rise in the CA19-9 marker level. In the postoperative period, immunochemotherapy with the drug amitosine was instituted. Median survival of patients came up to more than 8 months. In four patients, median survival was 38 months.

[Immunochemical studies of the system of specific proteins of the human placenta]. / Immunokhimicheskie issledovaniia sistemy spetsificheskikh belkov platsenty cheloveka.

The levels of placental lactogen, (PL), trophoblastic beta-globulin (TBG), placental alpha-microglobulin (PAMG-1), alpha 2-microglobulin of fertility (AMGF) in the blood serum of females, amniotic liquid and tissue of the placenta during pregnancy were comparatively studied and the protein-synthesizing function in the placenta in gestosis was evaluated. An original approach to differential assessment of the placental function was developed, by using the comprehensive serological immunochemical assay for placental proteins, which was based on concurrent immunodiffuse determination of PL, TBG, and enzyme immunoassay for AMGF and PAMG-1.

[The clinical importance of the complex determination of placental proteins in gestosis]. / Klinicheskoe znachenie kompleksnogo opredeleniia platsentarnykh belkov pri gestoze.

Parallel studies of a complex of placental proteins (placental lactogen, trophoblastic beta-globulin, etc.) will help more precisely detect placental dysfunction at early stages of gestosis, assess fetal status, and timely start correcting therapy. Solcoseryl therapy of placental dysfunction in gestosis is justified in complex with routine therapeutic methods and advisable in slight and medium-severity gestoses.