RESUMO
The JAK2 V617F somatic mutation is one of the most frequent markers of CHIP (clonal hematopoiesis of indeterminate potential). CHIP is characterized by the presence of a myeloid cells clone in peripheral blood in the absence of the sufficient reasons to diagnose the hematologic disease. The CHIP is proposed as a potential independent risk factor for vascular pathology. The aim of this study is to identify carriers of JAK2 V617F mutation among patients admitted for planned hospitalization at the Federal Center of Cardiovascular Surgery of Krasnoyarsk. MATERIALS AND METHODS: The study included 930 venous blood samples. JAK2 V617F mutation was detected by using the allele - specific real time polymerase chain reaction. RESULTS: JAK2 V617F mutation was detected in 15 (1.6%) patients, but only two of them had blood cell count that could cause a hematological disease to be suspected. CONCLUSION: The inclusion of the JAK2 V617F mutation detection in the complex of laboratory tests of the cardiovascular patients can facilitate the timely identification of patients with increased thrombotic risk, as well as the timely diagnosis of myeloproliferative diseases.
Assuntos
Doenças Cardiovasculares/genética , Cromossomos Humanos X/genética , Janus Quinase 2/genética , Transtornos Mieloproliferativos/genética , Alelos , Doenças Cardiovasculares/sangue , Doenças Cardiovasculares/diagnóstico , Testes Genéticos , Humanos , Mutação , Transtornos Mieloproliferativos/sangue , Transtornos Mieloproliferativos/diagnóstico , Reação em Cadeia da Polimerase em Tempo RealRESUMO
In-plane hole g factors measured in quantum point contacts based on p-type heterostructures strongly depend on the orientation of the magnetic field with respect to the electric current. This effect, first reported a decade ago and confirmed in a number of publications, has remained an open problem. In this work, we present systematic experimental studies to disentangle different mechanisms contributing to the effect and develop the theory which describes it successfully. We show that there is a new mechanism for the anisotropy related to the existence of an additional B_{+}k_{-}^{4}σ_{+} effective Zeeman interaction for holes, which is kinematically different from the standard single Zeeman term B_{-}k_{-}^{2}σ_{+} considered until now.
RESUMO
Results of treatment of 229 patients, suffering an acute necrotic pancreatitis, complicated by peripancreatic infiltrate, were analyzed. To all the patients antibiotic prophylaxis and antibiotic therapy were conducted. In 63 (27.5%) patients the methods of extracorporal hemocorrection were applied, and in 108 (47.1%)--the "four--catheters" rule (catheter for epidural anesthesia, installment of the feeding intestinal probe further than the Treitz ligament level, the central vein catheterization, the programmed laparocentesis). In 31 (13.5%) patients there were determined the activity of mononuclear phagocytes and production of ROS (the oxygen active forms) by them in peripheral blood with objective for the purulent-septic complications prognostication. In 14 (6.1%) patients purulent--septic complications have occurred, postoperative lethality was 21.4%, general lethality--3.4%.
Assuntos
Antibacterianos/uso terapêutico , Pancreatite Necrosante Aguda/diagnóstico , Pancreatite Necrosante Aguda/terapia , Sepse/diagnóstico , Sepse/terapia , Adulto , Líquido Ascítico/efeitos dos fármacos , Cateteres de Demora , Feminino , Hemoperfusão , Humanos , Leucócitos Mononucleares/efeitos dos fármacos , Leucócitos Mononucleares/metabolismo , Leucócitos Mononucleares/patologia , Masculino , Pessoa de Meia-Idade , Pancreatite Necrosante Aguda/complicações , Pancreatite Necrosante Aguda/mortalidade , Prognóstico , Espécies Reativas de Oxigênio/metabolismo , Sepse/etiologia , Sepse/mortalidade , Análise de Sobrevida , Resultado do TratamentoRESUMO
We report the observation of the Fermi energy controlled redirection of the ballistic electron flow in a three-terminal system based on a small (100 nm) triangular quantum dot defined in a two-dimensional electron gas (2DEG). Measurement shows strong large-scale sign-changing oscillations of the partial conductance coefficient difference G(21) - G(23) on the gate voltage in zero magnetic field. Simple formulas and numerical simulation show that the effect can be explained by quantum interference and is associated with weak asymmetry of the dot or inequality of the ports connecting the dot to the 2DEG reservoirs. The effect may be strengthened by a weak perpendicular magnetic field. We also consider an additional three-terminal system in which the direction of the electron flow can be controlled by the voltage on the scanning gate microscopy (SGM) tip.
Assuntos
Transporte de Elétrons , Pontos Quânticos , Semicondutores , Condutividade Elétrica , Teoria QuânticaAssuntos
Descompressão Cirúrgica/métodos , Neoplasias Duodenais/complicações , Neoplasias Hepáticas/complicações , Ductos Pancreáticos/cirurgia , Neoplasias Pancreáticas/complicações , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Neoplasias Duodenais/diagnóstico por imagem , Neoplasias Duodenais/epidemiologia , Neoplasias Duodenais/cirurgia , Feminino , Humanos , Avaliação de Estado de Karnofsky , Neoplasias Hepáticas/diagnóstico por imagem , Neoplasias Hepáticas/epidemiologia , Neoplasias Hepáticas/cirurgia , Masculino , Pessoa de Meia-Idade , Ductos Pancreáticos/diagnóstico por imagem , Neoplasias Pancreáticas/diagnóstico por imagem , Neoplasias Pancreáticas/epidemiologia , Neoplasias Pancreáticas/cirurgia , Ultrassonografia , Adulto JovemRESUMO
An unusual increase of the conductance with temperature is observed in clean quantum point contacts for conductances larger than 2(e2/h). At the same time, a positive magnetoresistance arises at high temperatures. A model accounting for electron-electron interactions mediated by boundaries (scattering on Friedel oscillations) qualitatively describes the observation. It is supported by a numerical simulation at zero magnetic field.
RESUMO
Over the period 1998-2001 a total of 78 patients with III to IV stage carcinoma of the pancreas complicated by jaundice underwent symptomatic and palliative operations. In all patients, the diagnosis was verified histologically with the aid of intraoperative fine-needle biopsy, incision biopsy or in the postoperative period marked by appearance of metastases in the liver--by progressive rise in the CA19-9 marker level. In the postoperative period, immunochemotherapy with the drug amitosine was instituted. Median survival of patients came up to more than 8 months. In four patients, median survival was 38 months.
Assuntos
Carcinoma/complicações , Icterícia/complicações , Neoplasias Pancreáticas/complicações , Adjuvantes Imunológicos/uso terapêutico , Alcaloides/uso terapêutico , Carcinoma/mortalidade , Feminino , Humanos , Neoplasias Hepáticas/patologia , Neoplasias Hepáticas/secundário , Masculino , Pessoa de Meia-Idade , Neoplasias Pancreáticas/mortalidade , Estudos Retrospectivos , Análise de SobrevidaRESUMO
The levels of placental lactogen, (PL), trophoblastic beta-globulin (TBG), placental alpha-microglobulin (PAMG-1), alpha 2-microglobulin of fertility (AMGF) in the blood serum of females, amniotic liquid and tissue of the placenta during pregnancy were comparatively studied and the protein-synthesizing function in the placenta in gestosis was evaluated. An original approach to differential assessment of the placental function was developed, by using the comprehensive serological immunochemical assay for placental proteins, which was based on concurrent immunodiffuse determination of PL, TBG, and enzyme immunoassay for AMGF and PAMG-1.
Assuntos
Proteínas da Gravidez/análise , Adulto , alfa-Globulinas/análise , Líquido Amniótico/química , Feminino , Humanos , Imunoquímica , Imunodifusão , Técnicas Imunoenzimáticas , Placenta/química , Lactogênio Placentário/análise , Lactogênio Placentário/sangue , Pré-Eclâmpsia/sangue , Pré-Eclâmpsia/diagnóstico , Gravidez , Proteínas da Gravidez/sangue , Glicoproteínas beta 1 Específicas da Gravidez/análise , Inibidores de Proteases/análise , Inibidores de Proteases/sangueRESUMO
Parallel studies of a complex of placental proteins (placental lactogen, trophoblastic beta-globulin, etc.) will help more precisely detect placental dysfunction at early stages of gestosis, assess fetal status, and timely start correcting therapy. Solcoseryl therapy of placental dysfunction in gestosis is justified in complex with routine therapeutic methods and advisable in slight and medium-severity gestoses.