1.
J Am Chem Soc
; 144(37): 16732-16736, 2022 09 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36088586
RESUMO
A new approach to polysubstituted spiropentanes is developed through a regio- and diastereoselective carbometalation of sp2-disubstituted cyclopropenes. The control of selectivity originates from a combined syn-facial diastereoselective carbometalation with a regio-directed addition. The regio-controlling element subsequently serves as a leaving group in an intramolecular nucleophilic substitution. This method allows the preparation of various polysubstituted spiropentanes with up to five contiguous stereocenters.