t-EER: Parameter-Free Tandem Evaluation of Countermeasures and Biometric Comparators.

Presentation attack (spoofing) detection (PAD) typically operates alongside biometric verification to improve reliablity in the face of spoofing attacks. Even though the two sub-systems operate in tandem to solve the single task of reliable biometric verification, they address different detection tasks and are hence typically evaluated separately. Evidence shows that this approach is suboptimal. We introduce a new metric for the joint evaluation of PAD solutions operating in situ with biometric verification. In contrast to the tandem detection cost function proposed recently, the new tandem equal error rate (t-EER) is parameter free. The combination of two classifiers nonetheless leads to a set of operating points at which false alarm and miss rates are equal and also dependent upon the prevalence of attacks. We therefore introduce the concurrent t-EER, a unique operating point which is invariable to the prevalence of attacks. Using both modality (and even application) agnostic simulated scores, as well as real scores for a voice biometrics application, we demonstrate application of the t-EER to a wide range of biometric system evaluations under attack. The proposed approach is a strong candidate metric for the tandem evaluation of PAD systems and biometric comparators.

Variations in hospital waste quantities and generation rates.

The relationship between public health and improper collection, handling, and disposal of solid wastes in general, and hospital wastes in particular, is quite clear. Hazardous and nonhazardous wastes generated from different divisions of two of the largest public hospitals (capacity of approximately 400 beds each) in Kuwait were quantified and generation rates were determined. The generation rates were related to some important factors such as the number of patients, number of beds, and the type of activity conducted in different sections of the hospitals. The relationship between the waste generation rate and the number of patients was more applicable than that expressed in terms of the number of beds. The rates observed were in the range of 4.89 to 5.4 kg/patient/day, which corresponds to 3.65 to 3.97 kg/bed/day, respectively. These generation rates were comparable with those reported in the literature for similar hospitals. Minimal waste quantities were collected in the weekends. The study indicated that the hospitals surveyed provide some segregation of hazardous and nonhazardous wastes. Hazardous wastes contributed about 53% of the total quantity of wastes generated at the hospitals.

Complicated hereditary spastic paraplegia with peripheral neuropathy, optic atrophy and mental retardation.

An 8-year old girl with a not previously described type of complicated hereditary spastic paraplegia (HSP) is presented. Spasticity in her lower limbs had already been recognized during infancy and worsened progressively. Severe delay in mental development was observed. Peripheral neuropathy and optic atrophy developed at 5 years of age. On brain magnetic resonance imaging, an abnormally thin corpus callosum was observed. Involvement of the fasciculus gracilis was suggested by somatosensory evoked potentials. To our knowledge, there has been no reported case of complicated HSP with peripheral neuropathy, optic atrophy and mental retardation so far. We postulate that our patient is a sporadic case of not previously described complicated HSP.

Nasal airway volumetric measurement using segmented HRCT images and acoustic rhinometry.

Semiautomatic segmentation methods using High Resolution Computed Tomography (HRCT) or Magnetic Resonance Imaging give accurate and reproducible volumetric measurements in various intracranial diseases. In this prospective study, for the first time in literature, with the help of a new semiautomatic segmentation technique and coronal HRCT, we correlated the volumes and cross-sectional areas of the nasal cavity with those obtained by clinical acoustic rhinometry in 14 patients with chronic sinusitis. The measurements obtained by both techniques showed statistically significant correlations between volumes in the anterior and middle parts, but statistically poor correlations between the volumes in the posterior part of the nasal cavity. Coronal HRCT and our new microcomputer applicable semiautomatic segmentation software proved compatible with daily clinical practice. Based on the promising results of our study, we recommend the use of this technique in the validation studies of acoustic rhinometry and in complicated cases as a complementary examination in the evaluation of nasal cavity.

Involvement of the spinal posterior horn in Gerstmann-Sträussler-Scheinker disease (PrP P102L).

OBJECTIVE: The authors studied the pathomechanisms of the characteristics associated with Gerstmann-Sträussler-Scheinker disease (GSS). BACKGROUND: GSS, associated with a missense mutation at codon 102 of the prion protein (PrP) gene (GSS102), is a hereditary disorder that presents with progressive ataxia and dementia, and is characterized by the loss of deep tendon reflexes and painful dysesthesias of the legs in its early stage. METHODS: The authors conducted immunohistochemical studies of the spinal cord and peripheral nervous system in one of two patients from a Japanese family with GSS102 in comparison with patients with GSS105. RESULTS: The authors found intense PrP immunoreactivities mainly in the posterior horn of the spinal cord, but not in the dorsal root ganglia or peripheral nerves. In addition to PrP amyloid plaques, synaptic-type, fine granular PrP deposits were distributed in the spinal posterior horns. In contrast to the GSS102 patient, the spinal cords of the GSS105 patients showed no granular PrP deposits. CONCLUSIONS: The PrP abnormalities in synaptic structures of the spinal posterior horn may cause synaptic dysfunction that leads to loss of deep tendon reflexes and painful dysesthesias in patients with GSS102.

[Age-related changes in movement-related cortical potentials].

Movement-related cortical potentials (MRCP) were measured in young normal subjects (age < 40) and aged normal subjects (age > or = 60). All were right-handed. MRCPs were recorded for voluntary self-paced extension of the right middle finger or the right foot. For the middle finger extension the latency and slope of the Bereitschaftspotential (BP) and the negative slope (NS') were measured at the contralateral hand motor area, and for the foot movement they were measured from Cz. MRCPs for the finger extension were examined in 12 young subjects (5 men, 7 women, 22-38 years old, mean age 26.3 +/- 5.2 years) and 18 aged subjects (9 men, 9 women, 60-82 years old, mean age 69.4 +/- 7.2 years). BP latency and NS' latency were significantly longer in the aged subjects than in the young subjects (p < 0.001 and p < 0.05, respectively). MRCPs for the foot movement were measured in 10 young subjects (3 men, 7 women, 22-38 years old, mean age 27.1 +/- 5.4 years) and 10 aged subjects (5 men, 5 women, 60-82 years old, mean age 70.3 +/- 8.1 years). BP latency was significantly longer in the aged subjects than in the young subjects (p < 0.05), but NS' latency was not. For both finger and foot extension, neither BP slope nor NS' slope differed significantly between the groups, although both slopes were steeper in the young subjects than the aged ones. These findings suggest that the time required by the cerebrum to prepare for voluntary movement and the period of preparation for movement are longer in aged subjects than in young subjects.

Myotonia congenita with painful muscle cramps.

A sporadic Japanese case of myotonia congenita with painful muscle cramps is reported. Electromyographic examinations disclosed myotonic discharge with dive bomber sounds at insertion, and high-amplitude, high-frequency motor unit potentials during the muscle cramps. Biopsied muscle specimens and EMG findings showed non-specific mild myopathic changes. There was no abnormal expansion of CTG repeat within the myotonic dystrophy gene. This patient's disorder closely resembles Becker's myotonia congenita Type II though the family history of was non contributory.

Hereditary distal dominant amyotrophy followed by spastic paraplegia.

Clinical, neurophysiological and neuropathological investigations were performed on five patients from two families with autosomal dominant distal amyotrophy followed by spastic paraplegia and with a positive history in two generations of these two families. All cases in the two families had a benign clinical course, although two mothers could not walk without support at around 60 years old. Neurophysiological studies revealed normal maximum conduction velocities of peripheral sensory and motor nerves, and the central spinal sensory pathway. Distribution of motor nerve conduction velocities in the ulnar nerve had a normal pattern except for one patient who had severe deformities of the cervical vertebrae. The biopsied sural nerve disclosed no distinct abnormalities in any cases. From these results, we confirmed preservation of the myelinated nerve fibers of motor and sensory peripheral nerves.

[A case of multiple sclerosis manifesting piano playing movement].

We report a case of 33-year-old man with multiple sclerosis, showing piano playing movement in both hands. His course of multiple sclerosis was remittent/progressive during 2 years and the clinical manifestation suggested the spinal cord involvement. On July 15, 1991, he was admitted with numbness of the right limbs, and then developed piano playing movement in both hands, more marked in the right side. Neurological examination revealed mild weakness in the right upper extremity, and rough touch, pain, and temperature sensation were slightly decreased. However, there was no deep sensory abnormalities, such as vibration, fine touch, and position senses. Vibration sense was lost below ilium. CSF examination showed elevation of IgG index (1.6), three oligoclonal bands and myelin basic protein content of 2.4 ng/ml. There was no HTLV-I antibody in CSF. SSEP, elicited by median nerve stimulation at the right wrist, showed no N13 and low amplitude of N20. T2-weighted images of cervical MRI revealed area of high signal intensity at the C3-C4 level. The piano playing movement gradually improved and disappeared by the initiation of steroid hormone therapy. It was considered that involuntary movement in this patient was due to the spinal cord lesion caused by multiple sclerosis. These findings suggested that the involuntary movement like pseudoathetosis could present without deep sensory abnormalities.

[A case of autoimmune polyglandular deficiency associated with progressive myopathy].

We reported a 29-year-old woman with autoimmune polyglandular deficiency (APGD) type 1 accompanied by progressive myopathy. She had chronic mucocutaneous candidiasis at the age of 3, primary hypothyroidism at 12, insulin dependent diabetes mellitus at 27, and adrenal insufficiency at 29 years. Laboratory findings indicated an underlying defect in cell mediated immunity. Meanwhile, she had progressive muscular weakness and wasting at the age of 22 years which brought her to our hospital at 29 years. On admission, she could not walk without support and raise her arms up to the level of shoulders. Moderate to severe muscle wasting as well as weakness was observed in the limb girdle muscles. Serum CK levels were mildly elevated. A needle EMG examination disclosed short-duration and low-amplitude polyphasic motor units at voluntary contraction with few fibrillations and positive sharp waves at rest. On muscle CT examination, decreased density was detected in the neck extensor, paravertebral, rectus femoris, vastus intermedius, biceps femoris and soleus muscles. Muscle biopsy was performed on the biceps brachii and rectus femoris muscles. The former showed chronic dystrophic changes including marked variation in fiber size with necrotic and degenerating process, interstitial fibrosis, and lobulated and right fibers. In the latter, in addition to variation in fiber size with some necrotic fibers and occasional multi-core structures, nemaline bodies were seen in approximately 30% of muscle fibers. The progressive muscle involvement in our patient might be induced from 1) endocrine abnormality, 2) autoimmune disorder, and/or 3) coincidental complication of nemaline myopathy or limb girdle muscular dystrophy. The clinical and laboratory examinations, however, failed to support any of them.(ABSTRACT TRUNCATED AT 250 WORDS)

Synthesis and its properties of oligonucleotide analogue containing thiocarbamate interlinkages.

Novel nucleotide analogues have been synthesized from morpholine subunits with thiocarbamate linkages. They indicated much stronger interaction with poly U or poly dT than the corresponding natural oligodeoxyribonucleotides. Solubility of the analogues in water was greatly enhanced by introducing sulfate groups at their both ends.

Supranuclear paralysis preventing lid closure in amyotrophic lateral sclerosis.

We report a case of amyotrophic lateral sclerosis (ALS) in which the ability to close the eyes on command or voluntarily, was lost in spite of retention of reflex activity. A electrophysiological study of the blink reflex revealed a prominent R1 component with normal latency, which confirmed that the blink reflex was exactly preserved and also suggested a hemispherical lesion. Postmortem examination disclosed prominent cortical and subcortical lesions of the precentral areas on both sides. These lesions seem to be very closely related to the inability to initiate lid closing.

Glabella tap sign. Is it due to a lack of R2-habituation?

In 30 patients with Parkinson's disease, 55 patients with other neurological disorders and 25 normal subjects, both upper eyelid movements and orbicularis oculi reflexes to repetitive glabella taps were simultaneously recorded using a newly devised apparatus for the measurement of eyelid movement. Upper lid movement during the blink reflex has been thought to correspond to the late component of the two components of the orbicularis oculi reflex, and failure of habituation of the late component to repetitive stimuli has been considered to be responsible for the glabella tap sign. However, the present study showed that the eyelid lowered after the early component (R1), and habituation of the late component (R2) was recognized in 31% of subjects with the glabella tap sign. This shows that there is no direct causal relationship between the glabella tap sign and lack of the habituation of the late component.

Synthesis of ribulose biphosphate carboxylase in greening pea leaves. Coordination of mRNA level of two subunits.

Ribulose biphosphate carboxylase/oxygenase, with its large subunit encoded in the chloroplast and the small subunit in the nucleus, is induced by light. Accumulation of the enzyme, its two mRNA levels, and the synthesis rate of enzyme protein in pea leaves were followed during induction to understand the role of mRNA levels during greening subunit synthesis. The relative mRNA levels for the large and the small subunits increased coordinately up to 3-4 days, which almost corresponded to an inflection point of the accumulation profile of RuBisCO, and then the two mRNA levels gradually decreased. To obtain information of subunit synthesis, the extent of labelling of the two subunits were determined for both assembled and unassembled subunits using specific IgG. Unassembled subunits were found for both polypeptides, with a slight excess of the small one. The observed synthesis rates of the small and the large subunits were roughly coordinated without overproduction and almost stoichiometric amounts of the two polypeptides were found. The profiles of observed synthesis rate of the two subunits and the holoenzyme were similar to those of their mRNA levels. These results suggest that the synthesis of ribulose biphosphate carboxylase/oxygenase protein and its accumulation are dependent on the coordinated change of the two mRNA levels in greening pea leaves.