RESUMO
Folic acid has less effect than 5-formyltetrahydofolic acid (folinic acid) in the alleviation of folate deficiency in cultured HEp 2 cells as measured by the deoxyuridine suppression test. Folic acid inhibits the metabolism of 5-formyltetrahydrofolic acid in vitro, is contraindicated in some cases of clinical folate deficiency and may be inappropriate in others.
Assuntos
Deficiência de Ácido Fólico/metabolismo , Ácido Fólico/farmacologia , Formiltetra-Hidrofolatos/farmacologia , Tetra-Hidrofolatos/farmacologia , Células Tumorais Cultivadas/efeitos dos fármacos , Ácido Fólico/metabolismo , Formiltetra-Hidrofolatos/metabolismo , Humanos , Timidina/farmacocinética , Células Tumorais Cultivadas/metabolismoRESUMO
In a randomized trial, 149 patients with uncomplicated gonorrhoea were treated with a single intramuscular dose of 1.0 g mezlocillin, 150 with 2.0 g ampicillin plus 1.0 g probenecid orally and 150 with a single dose of 1.8 mega units of procaine penicillin. Cure rates at 3, 10 and 17 days after treatment were 97%, 99% and 96% for mezlocillin, 95%, 99% and 95% for ampicillin, and 97%, 98% and 98% for procaine penicillin, respectively. The incidence of post-gonococcal urethritis was 11.3% for ampicillin plus probenecid, 10.9% for procaine penicillin and 10.5% for mezlocillin. Side-effects after all three regimens were minimal.