RESUMO
A ten-year retrospective study has been undertaken on a group of ten haemophiliacs for whom previous haematological and radiological data was available. Radiological and clinical assessment of their knees and elbows (40 joints) have been correlated to the accurate recording of all haemarthroses suffered by these joints. There is a statistically significant association between the number of haemarthroses and the radiological change in the joint, as determined significant association between number of haemarthroses and deterioration in clinical function. Several bleeds can occur in a haemophilic joint without necessarily causing permanent radiological change; this new finding in adults may be due to modern therapy.
Assuntos
Hemofilia A/complicações , Artropatias/diagnóstico por imagem , Articulação do Cotovelo/diagnóstico por imagem , Articulação do Cotovelo/fisiopatologia , Humanos , Artropatias/etiologia , Artropatias/fisiopatologia , Articulação do Joelho/diagnóstico por imagem , Articulação do Joelho/fisiopatologia , Movimento , Radiografia , Estudos RetrospectivosAssuntos
Leucemia Induzida por Radiação/etiologia , Espondilite Anquilosante/radioterapia , Adulto , Feminino , Humanos , Leucemia Mieloide/etiologia , Leucemia Mieloide Aguda/etiologia , Linfoma Difuso de Grandes Células B/etiologia , Linfoma não Hodgkin/etiologia , Masculino , Pessoa de Meia-IdadeRESUMO
5 severe haemophiliacs were infused with cryoprecipitate prepared by the continuous thaw-siphon technique, with cryoprecipitate prepared by overnight thawing and with intermediate-purity factor VIII concentrate. All 3 preparations gave a similar mean half-life for coagulant factor VIII of approximately 10 hours. The immediate recovery of this activity was similar for the 2 cryoprecipitates, but higher for the purified concentrate.
Assuntos
Fator VIII/normas , Adulto , Fator VIII/uso terapêutico , Congelamento , Meia-Vida , Hemofilia A/tratamento farmacológico , Humanos , MétodosRESUMO
A patient with myelofibrosis complicated by massive splenomegaly underwent splenectomy to alleviate the increasing transfusion requirements and iron overload. The platelets exhibited qualitative defects pre-operatively. Following splenectomy the patient bled profusely and required massive blood and platelet transfusions. The postoperative haemorrhage was controlled by giving sufficient platelets to normalize the platelet aggregation.
Assuntos
Transfusão de Sangue , Transfusão de Plaquetas , Mielofibrose Primária/cirurgia , Plaquetas/patologia , Feminino , Hemorragia/etiologia , Humanos , Pessoa de Meia-Idade , Agregação Plaquetária , Complicações Pós-Operatórias , EsplenectomiaRESUMO
Giant granules were present in the cytoplasm of marrow granulocytes and in abnormal immature leucocytes circulating in the blood of a patient with promyelocytic leukaemia associated with intravascular coagulation. These granules resembled those seen in Chediak-Higashi syndrome.
Assuntos
Medula Óssea/patologia , Síndrome de Chediak-Higashi/sangue , Grânulos Citoplasmáticos , Coagulação Intravascular Disseminada/complicações , Leucemia Mieloide Aguda/sangue , Leucócitos/ultraestrutura , Grânulos Citoplasmáticos/ultraestrutura , Coagulação Intravascular Disseminada/sangue , Feminino , Granulócitos/ultraestrutura , Humanos , Leucemia Mieloide Aguda/complicações , Pessoa de Meia-IdadeRESUMO
Peripheral blood leucocyte counts in 104 thyrotoxic (Graves' disease) patients were compared with those in 107 normal subjects of similar age and sex. The thyrotoxic patients had a significant leucopenia with an absolute and relative neutropenia. They also had a relative lymphocytosis but the absolute lymphocyte count was within normal limits. The relative and absolute monocyte counts were normal.