[Cytogenetic disorders iin patients with chronic hepatitis B and C]. / Tsitogeneticheskie narusheniia u bol'nykh khronicheskimi gepatitami B i C.

The chromosomal apparatus of peripheral blood lymphocytes was studied in 19 patients with chronic hepatitis B (CHB) and 17 patients with chronic hepatitis C (CHC). Significant changes in cytogenetic indices were revealed in the both groups. Incidence of aberrant cells in CHC exceeded significantly that in CHB (15.3 +/- 1.5% vs 11.1 +/- 0.9% respectively; P < 0.05). Frequencies of aberration per cell and chromatid fragments were also significantly higher in CHC compared with both CHB and practically normal donor groups.

[Circulating immune complexes and the indices of the kallikrein-kinin system in viral hepatitis B]. / Tsirkuliruiushchie immunnye kompleksy i pokazateli kallikrein-kininovoi sistemy pri virusnom gepatite B.

The authors describe the dynamics of circulating immune complexes and indices of kallikrein-kinin system in the dynamics of the disease and convalescence period of patients with viral hepatitis B. A relationship was established between indices of the kallikrein-kinin system and their prognostic significance in the formation of unfavourable outcomes of the disease.

[Clinico-genetic and hemostatic disorders in viral hepatitis B]. / Kliniko-geneticheskie i gemostaziologicheskie narusheniia pri virusnom gepatite B.

Viral hepatitis B is characterized by pronounced chromatid and chromosome structural defects of peripheral blood T lymphocytes. The chromosome aberrations are longer in hepatitis B than in hepatitis A, in protracted and chronic forms in particular. Excessive circulating immune complexes occur in acute hepatitis. Their concentration is higher in protracted viral hepatitis B. Hemostasis is affected too: the more severe hemostatic abnormality, the more grave the disease. Hemocoagulation alterations are linked with the level of circulating immune complexes.