Strongly correlated superconductivity in a copper-based metal-organic framework with a perfect kagome lattice.

Metal-organic frameworks (MOFs), which are self-assemblies of metal ions and organic ligands, provide a tunable platform to search a new state of matter. A two-dimensional (2D) perfect kagome lattice, whose geometrical frustration is a key to realizing quantum spin liquids, has been formed in the π - d conjugated 2D MOF [Cu3(C6S6)] n (Cu-BHT). The recent discovery of its superconductivity with a critical temperature T c of 0.25 kelvin raises fundamental questions about the nature of electron pairing. Here, we show that Cu-BHT is a strongly correlated unconventional superconductor with extremely low superfluid density. A nonexponential temperature dependence of superfluid density is observed, indicating the possible presence of superconducting gap nodes. The magnitude of superfluid density is much smaller than those in conventional superconductors and follows the Uemura's relation of strongly correlated superconductors. These results imply that the unconventional superconductivity in Cu-BHT originates from electron correlations related to spin fluctuations of kagome lattice.

5-fs, Multi-mJ, CEP-locked parametric chirped-pulse amplifier pumped by a 450-nm source at 1 kHz.

We report on the development of an optical parametric chirpedpulse amplifier at a 1-kHz repetition rate with a 5.5-fs pulse duration, a 2.7-mJ pulse energy and carrier-envelope phase-control. The amplifier is pumped by a 450-nm pulse from a frequency-doubled Ti:sapphire laser.

The effect of core framework designs on the fracture loads of all-ceramic fixed partial dentures on posterior implants.

This study evaluated the fracture loads of three-unit all-ceramic bridges on implants; the core frameworks of the bridges were made of zirconium oxide. Three core framework designs were fabricated according to the design of the bars between the retainers: (i) straight, (ii) curved in the occlusal direction, or (iii) curved in the gingival direction. A static load was applied at the centre of the pontic, and the mean initial crack and final fracture loads were measured and compared. The core framework curved in the occlusal direction had the highest final fracture loads; there were significant differences (P < 0.05) in the mean final fracture load, whereas initial fracture load, which fractured of veneered porcelain, did not show significant differences among three designs. The all-ceramic bridges on the implants made with Procera zirconium core frameworks had high final fracture load. The core framework design that curved in the occlusal direction helped the framework withstand the occlusal load, which results in reliable prostheses, especially in the molar region.

Observation of light-phase-sensitive photoemission from a metal.

We demonstrate that multiphoton-induced photoelectron emission from a gold surface caused by low-energy (unamplified) 4-fs, 750-nm laser pulses is sensitive to the timing of electric field oscillations with respect to the pulse peak. This observation confirms recent theoretical predictions and opens the door to measuring the absolute value of the carrier-envelope phase difference of few-cycle light pulses with a solid-state detector.

High-Average-Power Self-Starting Mode-Locked Ti:sapphire Laser With a Broadband Semiconductor Saturable-Absorber Mirror.

We present a novel high-power, self-starting mode-locked Ti:sapphire laser with a semiconductor saturable-absorber mirror as the starter element. This laser, whose slope efficiency is 22%, generates pulses with an average power as high as 1.7 W and a pulse width as short as 16 fs. The self-starting process is also investigated.

Carrier-phase control among subharmonic pulses in a femtosecond optical parametric oscillator.

We have generated femtosecond subharmonic pulses by using an optical parametric oscillator. The optical frequencies of the idler and the signal are one third and two thirds, respectively, of the optical frequency of the pump pulse. The carrier phase of the signal pulse relative to that of the pump pulse was locked by electronic feedback. The carrier-envelope phase slip frequency of the signal pulse relative to that of the pump was locked to F/6 , where F is defined as the repetition frequency.

Single-shot measurement of carrier-envelope phase changes by spectral interferometry.

We demonstrated single-shot measurements of spectral interference between a white-light continuum generated in a hollow-fiber and its second harmonic. The interference has information on the carrier-envelope phase of an input pulse to the fiber and the time delay of the blue wing of the continuum. By analyzing the observed spectral interference, we estimated shot-by-shot changes of the carrier-envelope phase. This method is useful for determining the carrier-envelope phase changes of a low-repetition-rate, high-intensity laser.

Generation of two-color femtosecond pulses by self-synchronizing Ti:sapphire and Cr:forsterite lasers.

We report a novel technique for the synchronization of two different femtosecond solid-state lasers by crossing of both laser pulses in a Kerr medium. Stable dual-wavelength femtosecond pulses at central wavelengths of 820 and 1250 nm have been obtained. The tolerance of cavity-length mismatch is ~0.6mum , where the pulse widths of the Ti:sapphire and the Cr:forsterite lasers are 18 and 40 fs, respectively, at average powers of 600 and 110 mW. The typical timing jitter derived from the cross correlation is less than 3 fs.

Measurement of the optical phase relation among subharmonic pulses in a femtosecond optical parametric oscillator.

We observed the phase relation among subharmonic pulses generated by a femtosecond optical parametric oscillator (OPO). The ratio of the optical frequencies of the idler, the signal, and the pump pulses was set to 1:2:3. Under these conditions the wavelengths of the second harmonic of the signal pulse and the sum frequency between the pump and the idler pulses are the same. The beat signal between these two pulses represents the phase relationship among the pump, the signal, and the idler. The beat frequency varied when the cavity length of the OPO was changed.

Timing jitter in a kilohertz regenerative amplifier of a femtosecond-pulse Ti:Al(2)O(3) laser.

We measure the timing error of femtosecond pulses amplified by a Ti:sapphire regenerative amplifier at a 1-kHz repetition rate by use of a modified cross-correlation technique. Linearly frequency-chirped amplified pulses are frequency mixed with transform-limited oscillator pulses. A shift in the sum frequency corresponds to the timing error of each amplified pulse relative to the oscillator pulses. The timing error was measured every 6 ms with approximately 1-fs resolution over a measurable range of 400 fs.

[Phase 2 clinical study of 123I-IBF, a dopamine D2 receptor imaging agent, to evaluate clinical efficacy and safety in Parkinson's disease and Parkinson syndromes].

A Phase 2 multicenter trial of 123I-IBF, (S)-5-iodo-7-N-[(1-ethyl-2- pyrrolidinyl)methyl]carboxamido-2,3-dihydrobenzofuran, was conducted to evaluate its clinical efficacy and safety in 158 patients with Parkinson's disease (PD) or Parkinson syndromes (PS). SPECT data were acquired at two hours (2H-SPECT), after intravenous injection of 123I-IBF (167 MBq). Additional SPECT scan at three hours (3H-SPECT) and dynamic SPECT scan at most until one hour were performed when possible. No severe side effects due to 123I-IBF injection were observed. The sensitivity, specificity and accuracy for discriminating PS from PD using the striatal specific binding count-to-frontal cortex count ratio (St/Fc-1) in 3H-SPECT were 72.7%, 81.0% and 78.1% in 64 clinically definite cases (i.e., typical cases), respectively. The putamen-to-caudate ratios were significantly lower in striatonigral degeneration compared with those in PD. The contralateral-to-ipsilateral ratios against the symptomatic side of tremor and/or rigidity in the patients with PD (Hoehn & Yahr I) were significantly higher than the left-to-right ratios in the normal controls. St/Fc-1 in 3H-SPECT was significantly lower in the patients showing a poor response to levodopa than in those showing a good response. The dopamine D2 receptor binding potential (k3/k4), obtained by dynamic SPECT based on compartment model analysis, correlated well with the striatal specific binding count-to-occipital cortex count ratio. These results suggest that 123I-IBF is a promising agent for differential diagnosis and pathophysiological evaluation of PD and PS.

[Present and future of nuclear medicine].

In this age of "Medical Imaging", Nuclear Medicine has occupied a preeminent position, heralded by the following four points: the development of novel radio-nuclides containing compounds (radio-diagnostic and radio-therapeutic agents), the power of extremely sensitive new measuring devices, the highly reliable quantification of physio-pathological changes occurring in disease and the guidance to medical diagnosis. On those four points, Nuclear Medicine will continue to spread, but new frontiers are emerging, and it is challenged to provide measurements of consistently reliable accuracy to guide various forms of treatment and radiotherapy requiring a high standard of competence.

Stable mode-locking operation in a Cr:forsterite laser with a five-mirror cavity.

The experimental finding of more-stable mode-locking operation in a five-mirror cavity than in a conventional four-mirror cavity for a Cr:forsterite laser [IEEE J. Quantum Electron. 33, 1975 (1997)] was interpreted by ABCD-matrix formalism. Since the optimum cavity configuration operation for mode-locking operation was attainable in the middle of the stable cavity condition, we conclude that one can easily achieve KLM alignment and stable mode locking with a five-mirror cavity.

Generation of 12-fs pulses from a diode-pumped Kerr-lens mode-locked Cr:LiSAF laser.

We demonstrate 12-fs-pulse generation from a diode-pumped Kerr-lens mode-locked Cr:LiSAF laser. This is to our knowledge the shortest pulse ever produced from a mode-locked Cr:LiSAF laser. Based on an improved estimation of the intracavity dispersions, we utilized BK7 glass for the Brewster-prism-pair material.

Self-starting mode-locked Cr(4+):YAG laser with a low-loss broadband semiconductor saturable-absorber mirror.

We report a self-starting mode-locked Cr(4+):YAG laser with a low-loss broadband metal reflector-based semiconductor saturable-absorber mirror. The minimum pulse width was 44 fs at a wavelength of 1520 nm.

Femtosecond Cr:forsterite laser diode pumped by a double-clad fiber.

We present a compact, all-solid-state femtosecond Cr:forsterite laser. The laser is pumped by diodes through a double-clad fiber. Kerr-lens mode locking is initiated and stabilized by a semiconductor saturable-absorber mirror with a single InGaAs quantum well. This system generates transform-limited 80-fs pulses near 1.3microm . An average power of 68 mW with fluctuation of much less than 1% is obtained with 3.8 W of absorbed pump power. The stability, efficiency, compactness, and potential for scaling to higher power of this system make it an attractive short-pulse source for applications.

Broadband semiconductor saturable-absorber mirror for a self-starting mode-locked Cr:forsterite laser.

We report a low-loss broadband semiconductor saturable-absorber mirror (SESAM) that uses gold film as the reflector. A semiconductor- SiO(2) double-layer stack enhances the reflectivity of the gold film. This low-loss SESAM was used in a mode-locked Cr:forsterite laser to produce self-starting 20-fs-scale laser pulses at 1.3 microm . The structure can be applied to SESAM's for other wavelengths.

Diode-Pumped Cr:forsterite Laser Mode Locked by a Semiconductor Saturable Absorber.

We report the passive mode locking of a diode-pumped Cr:forsterite laser using a semiconductor saturable absorber. The laser generates 10-pJ pulses as short as 1.5 ps in duration with ~650 mW of absorbed pump power. We measured the transient reflectance of the saturable absorber mirror under different incident energy fluences by using a standard pump-probe method. The performance of this laser is also compared with a high-power fiber-laser-pumped femtosecond forsterite laser mode locked with the same absorber.

Self-starting mode-locked femtosecond forsterite laser with a semiconductor saturable-absorber mirror.

We report on a self-starting mode-locked femtosecond Cr:forsterite laser pumped by a diode-pumped Nd:YVO(4) laser. The mode locking is initiated by a semiconductor saturable-absorber mirror (SESAM). We also present the measured group delay of the forsterite crystal and the SESAM.

[Effectiveness of the radioactive strontium (89Sr) chloride agent, SMS.2P for pain palliation in patients with metastatic bone tumor in phase III multicenter clinical trial].

The phase III clinical trial of strontium-89 chloride agent (SMS.2P) was performed in 90 patients with painful bone metastases secondary to prostate (53), breast (18) and other types of cancer (19). Some patients experienced a transient increase in pain or nausea and vomiting. However both symptoms subsided and serious side effects were not observed in any of the patients. As reported, we confirmed some abnormal changes in peripheral blood picture. A decrease in the number of white blood cells and platelets was considered to be partly a result of bone marrow suppression due to 89Sr irradiation. Pain was substantially improved after 89Sr therapy in 58% of the patients and there was some alleviation in 12%. The release from pain was accompanied by an improved quality of life for these patients including sleep patterns and morbidity. Some patients were able to resume their former life styles. Most of the improved patients experienced pain relief from days to one week following 89Sr therapy and in half cases, this remained effective for 2 or 3 months. There were even cases in which the pain relief continued over an observation period of time of clinical study.