Unlocking the surface chemistry of ionic minerals: a high-throughput pipeline for modeling realistic interfaces.

A systematic procedure is introduced for modeling charge-neutral non-polar surfaces of ionic minerals containing polyatomic anions. By integrating distance- and charge-based clustering to identify chemical species within the mineral bulk, our pipeline, PolyCleaver, renders a variety of theoretically viable surface terminations. As a demonstrative example, this approach was applied to forsterite (Mg2SiO4), unveiling a rich interface landscape based on interactions with formaldehyde, a relevant multifaceted molecule, and more particularly in prebiotic chemistry. This high-throughput method, going beyond techniques traditionally applied in the modeling of minerals, offers new insights into the potential catalytic properties of diverse surfaces, enabling a broader exploration of synthetic pathways in complex mineral systems.

Revisiting ion-pair interactions in phase transfer catalysis: from ionic compounds to real catalyst systems.

Ion-pairing is a fundamental phenomenon that significantly influences phase-transfer catalysis. In this study, we conduct a comprehensive investigation of ion-pair interactions, aiming to establish a comprehensive understanding of their nature and implications. The study begins with the examination of polar ionic compounds to define the concept of an ion-pair in the context of phase-transfer catalysis. Subsequently, a diverse range of ion-pair catalyst models were explored to gain insight into the factors governing their interactions. Finally, the focus shifts towards the characterisation of real phase-transfer catalysts, bridging the gap between theoretical models and practical applications. Through a combination of computational approaches and theoretical analysis, this work provides valuable insight into the nature of ion-pair interactions within phase-transfer catalysis fields.

Systematic discovery of neoepitope-HLA pairs for neoantigens shared among patients and tumor types.

The broad application of precision cancer immunotherapies is limited by the number of validated neoepitopes that are common among patients or tumor types. To expand the known repertoire of shared neoantigen-human leukocyte antigen (HLA) complexes, we developed a high-throughput platform that coupled an in vitro peptide-HLA binding assay with engineered cellular models expressing individual HLA alleles in combination with a concatenated transgene harboring 47 common cancer neoantigens. From more than 24,000 possible neoepitope-HLA combinations, biochemical and computational assessment yielded 844 unique candidates, of which 86 were verified after immunoprecipitation mass spectrometry analyses of engineered, monoallelic cell lines. To evaluate the potential for immunogenicity, we identified T cell receptors that recognized select neoepitope-HLA pairs and elicited a response after introduction into human T cells. These cellular systems and our data on therapeutically relevant neoepitopes in their HLA contexts will aid researchers studying antigen processing as well as neoepitope targeting therapies.

Older children verify adult claims because they are skeptical of those claims.

We investigated children's information seeking in response to a surprising claim (Study 1, N = 109, 54 Female, Range = 4.02-6.94 years, 49% White, 21% Mixed Ethnicity, 19% Southeast Asian, September 2019-March 2020; Study 2, N = 154, 74 Female, Range = 4.09-7.99, 50% White, 20% Mixed Ethnicity, 17% Southeast Asian, September 2020-December 2020). Relative to younger children, older children more often expressed skepticism about the adult's surprising claims (1-year increase, OR = 2.70) and more often suggested exploration strategies appropriate for testing the specific claim they heard (1-year increase, OR = 1.42). Controlling for age, recommending more targeted exploration strategies was associated with a greater likelihood of expressing skepticism about the adult's claim.

Investigating the regulation of the unc-33 promoter by environmental stressors.

Environmental factors such as prenatal stress are hypothesized to contribute to the development of schizophrenia. Lee and colleagues determined rats exposed to prenatal stress exhibited decreased levels of only one protein, DPYSL2, in their prefrontal cortex and hippocampus. DYPSL2, a protein seen to be inactivated in schizophrenic patients, is important for neuronal development. The C. elegans homolog of DPYSL2, UNC-33, is also found to be critical for axonal outgrowth and synapse formation. Herein, we study the effects of environmental stressors such as increasing temperatures and pathogens on the expression of GFP driven by the unc-33 promoter. Results indicate that neuronal GFP expression was lower in C. elegans exposed to these prenatal stressors, making this the first report denoting an environmental regulation of the unc -33 promoter. This study provides insight into unc-33 and the regulation of its expression in relation to temperature and infection.

Usefulness of warning signs in the management of dengue patients / Utilidad de los signos de alarma en la atención de pacientes con dengue

Introduction: The dengue case classifications proposed by World Health Organization (WHO, 2009) include warning signs (WS) for recognizing early progression of disease toward the critical phase. Objective: To analyze the usefulness WS and challenges of the 2009 WHO dengue case classification in preventing and managing severe dengue cases. Methods: Data from 1439 adult patients diagnosed as dengue cases (2001-2002, 2006, 2012) at the Pedro Kourí Institute Hospital, in Havana Cuba, was revised. The WS were described and their predictive utility was considered in preventing shock in these patients with the use of crystalloids by calculating the sensitivity, specificity and positive / negative predictive values using both the 1997 and 2009 WHO dengue case classifications. Results: Plasma-leakage with shock was the main clinical form of severe dengue (95.3 percent). All severe cases due to plasma leakage had WS. The most frequent WS were mucosal bleeding (926 cases; 64.4 percent), frequent vomiting (361; 39.0 percent), abdominal pain or tenderness (404; 35.5 percent) and prostration (408; 28.4 percent). Mucosal bleeding and abdominal pain were good predictors of severity, appearing one day before shock. More than 75 percent of patients without WS there were not severe dengue. Most patients with warning signs were managed correctly and had an uneventful recovery. Conclusions: Identifying the WS recommended by WHO 2009 classification for crystalloid intravenous fluid treatment was crucial for the successful outcome of dengue cases(AU)

Introducción: La clasificación de dengue propuesta por la Organización Mundial de la Salud (OMS) en el 2019 incluye los signos de alarma (SA) para reconocer la rápida progresión de la enfermedad a la fase crítica. Objetivo: Analizar la utilidad de los SA y los retos de la clasificación de la OMS de 2009 para la prevención y manejo de los casos graves de dengue. Métodos: Se obtuvo información de 1439 pacientes adultos diagnosticados como casos de dengue (años: 2001-2002, 2006, 2012) en el Hospital del Instituto Pedro Kourí, en La Habana, Cuba. Se describieron los SA y se consideró su utilidad en la prevención del choque con el uso de soluciones cristaloides mediante el cálculo de la sensibilidad, especificidad y los valores positivo y negativo a partir de las clasificaciones de la OMS de 1997 y 2009. Resultados: La extravasación de plasma con choque fue la forma clínica principal del dengue grave (95,3 por ciento). Todos los casos graves debido a extravasación de plasma manifestaron SA. Los SA más frecuentes fueron el sangrado de mucosas (926 casos; 64,4 por ciento), los vómitos frecuentes (361; 39,0 por ciento), el dolor abdominal espontáneo o a la palpación (404; 35,5 por ciento) y la postración (408; 28,4 por ciento). El sangrado de mucosas y el dolor abdominal fueron buenos predictores de gravedad (aparecieron un día antes del choque). Más del 75 por ciento de los pacientes sin SA no tenían dengue grave. La mayoría de los pacientes con SA fueron tratados correctamente y se recuperaron sin complicaciones. Conclusiones: La identificación de SA recomendada por la clasificación de OMS de 2009 para el tratamiento con cristaloides fue crucial para la evolución exitosa de los casos de dengue(AU)

Theoretical Perspectives in Organocatalysis.

It is clear that the field of organocatalysis is continuously expanding during the last decades. With increasing computational capacity and new techniques, computational methods have provided a more economic approach to explore different chemical systems. This review offers a broad yet concise overview of current state-of-the-art studies that have employed novel strategies for catalyst design. The evolution of the all different theoretical approaches most commonly used within organocatalysis is discussed, from the traditional approach, manual-driven, to the most recent one, machine-driven.

Tuning the local chemical environment of ZnSe quantum dots with dithiols towards photocatalytic CO2 reduction.

Sunlight-driven CO2 reduction to renewable fuels is a promising strategy towards a closed carbon cycle in a circular economy. For that purpose, colloidal quantum dots (QDs) have emerged as a versatile light absorber platform that offers many possibilities for surface modification strategies. Considerable attention has been focused on tailoring the local chemical environment of the catalytic site for CO2 reduction with chemical functionalities ranging from amino acids to amines, imidazolium, pyridines, and others. Here we show that dithiols, a class of organic compounds previously unexplored in the context of CO2 reduction, can enhance photocatalytic CO2 reduction on ZnSe QDs. A short dithiol (1,2-ethanedithiol) activates the QD surface for CO2 reduction accompanied by a suppression of the competing H2 evolution reaction. In contrast, in the presence of an immobilized Ni(cyclam) co-catalyst, a longer dithiol (1,6-hexanedithiol) accelerates CO2 reduction. 1H-NMR spectroscopy studies of the dithiol-QD surface interactions reveal a strong affinity of the dithiols for the QD surface accompanied by a solvation sphere governed by hydrophobic interactions. Control experiments with a series of dithiol analogues (monothiol, mercaptoalcohol) render the hydrophobic chemical environment unlikely as the sole contribution of the enhancement of CO2 reduction. Density functional theory (DFT) calculations provide a framework to rationalize the observed dithiol length dependent activity through the analysis of the non-covalent interactions between the dangling thiol moiety and the CO2 reduction intermediates at the catalytic site. This work therefore introduces dithiol capping ligands as a straightforward means to enhance CO2 reduction catalysis on both bare and co-catalyst modified QDs by engineering the particle's chemical environment.

Descripción clínica de niños fallecidos por dengue hemorrágico durante la epidemia cubana de 1981

RESUMEN Introducción: El dengue es una importante arbovirosis en términos de morbilidad y mortalidad. Objetivo: Caracterizar clínica y epidemiológicamente a un grupo de fallecidos con dengue hemorrágico menores de 15 años durante la epidemia cubana de 1981. Métodos: estudio retrospectivo, descriptivo en una muestra de 67 pacientes. La información se extrajo de las historias clínicas. Resultados: La mayor parte de los pacientes estudiados tenían entre 3 y 10 años de edad, con similar distribución entre ambos sexos, de color de piel blanca en su mayoría, normopesos y con aparente estado de salud. Los síntomas predominantes fueron la fiebre, los vómitos y el sangramiento digestivo, que motivaron el ingreso a partir del 3er. día en la mayoría de las veces. El choque apareció generalmente entre el 4to. y 5to. día, precedido por los vómitos o el dolor abdominal y asociado al aumento del hematocrito y la trombocitopenia. Los referidos signos clínicos de alarma y otros menos frecuentes fueron capaces de anunciar el choque. Los signos radiográficos más encontrados fueron la opacidad y el derrame pleural derecho; en las necropsias predominó el sangramiento gastrointestinal, el derrame seroso y la necrosis hepática medio zonal. Conclusiones: La caracterización clinicoepidemiológica de los casos fallecidos por dengue durante la primera epidemia sufrida en la región de las Américas ha permitido conocer la evolución de la enfermedad y contribuido a la elaboración de las guías para su atención y tratamiento efectivo.

ABSTRACT Introduction: Dengue is an important arbovirus in terms of morbidity and mortality. Objective: Characterize clinically and epidemiologically a group of deceased with hemorrhagic dengue under 15 years of age during the Cuban epidemic of 1981. Methods: Retrospective, descriptive study in a sample of 67 patients. The information was extracted from medical records. Results: Most of the patients studied were between 3 and 10 years old, with similar distribution between both sexes, mostly white skin, normal weight and with apparent good state of health. The predominant symptoms were fever, vomiting and digestive bleeding, which motivated admission at the 3rd day in most cases. The shock usually appeared between the 4th. and 5th. day, preceded by vomiting or abdominal pain, and associated with increased hematocrit and thrombocytopenia. The most commonly found radiographic signs were opacity and right pleural effusion ; necropsies, gastrointestinal bleeding, serous effusion and zonal mid-hepatic necrosis predominated. Conclusions: The clinical-epidemiological study of the cases that died from dengue during the first epidemic suffered in the region of the Americas has made it possible to know the evolutionary particularities of the disease and contributed to the elaboration of guidelines for its care and effective treatment.

Successes and challenges in multiscale modelling of artificial metalloenzymes: the case study of POP-Rh2 cyclopropanase.

Molecular modelling applications in metalloenzyme design are still scarce due to a series of challenges. On top of that, the simulations of metal-mediated binding and the identification of catalytic competent geometries require both large conformational exploration and simulation of fine electronic properties. Here, we demonstrate how the incorporation of new tools in multiscale strategies, namely substrate diffusion exploration, allows taking a step further. As a showcase, the enantioselective profiles of the most outstanding variants of an artificial Rh2-based cyclopropanase (GSH, HFF and RFY) developed by Lewis and co-workers (Nat. Commun., 2015, 6, 7789 and Nat. Chem., 2018, 10, 318-324) have been rationalized. DFT calculations on the free-cofactor-mediated process identify the carbene insertion and the cyclopropanoid formation as crucial events, the latter being the enantiodetermining step, which displays up to 8 competitive orientations easily altered by the protein environment. The key intermediates of the reaction were docked into the protein scaffold showing that some mutated residues have direct interaction with the cofactor and/or the co-substrate. These interactions take the form of a direct coordination of Rh in GSH and HFF and a strong hydrophobic patch with the carbene moiety in RFY. Posterior molecular dynamics sustain that the cofactor induces global re-arrangements of the protein. Finally, massive exploration of substrate diffusion, based on the GPathFinder approach, defines this event as the origin of the enantioselectivity in GSH and RFY. For HFF, fine molecular dockings suggest that it is likely related to local interactions upon diffusion. This work shows how modelling of long-range mutations on the catalytic profiles of metalloenzymes may be unavoidable and software simulating substrate diffusion should be applied.

Dengue en el primer año de la vida / Dengue in the first year of life

Introducción: El dengue es considerada la más importante de todas las arbovirosis por su gran carga de enfermedad e implicaciones sociales. Es una enfermedad infecciosa causada por cualquiera de los cuatro serotipos del complejo dengue, que se trasmite al hombre a través de la picada de un mosquito del género Aedes. Objetivo: Caracterizar las manifestaciones clínicas en lactantes con dengue confirmado. Métodos: Se realizó un estudio observacional, descriptivo y retrospectivo de las manifestaciones clínicas de150 lactantes con diagnóstico de dengue confirmado por serología que fueron hospitalizados en el Hospital Materno Infantil Dr. Ángel Arturo Aballí en el período de julio- septiembre del año 2014. Resultados: Los lactantes entre 7 y 12 meses de edad fueron los más afectados (66,8 por ciento), con predominio del sexo femenino (54,0 por ciento). Las principales manifestaciones clínicas fueron: fiebre, manifestaciones respiratorias altas y exantema. La aparición de los signos de alarma coincidió con la defervescencia de la fiebre en 14 niños (9,3 por ciento) y los vómitos frecuentes y la letargia o irritabilidad fueron los síntomas más reiterados. Un solo paciente (0,7 por ciento) presentó cuadro clínico de choque. Conclusiones: Durante el primer año de vida, la enfermedad dengue puede presentarse de modo particular y semejar cualquier otra infección viral. El criterio epidemiológico tiene suma importancia, así como la presencia de fiebre, exantema y las manifestaciones respiratorias que no siempre se asocian al dengue en otras edades(AU)

Introduction: Dengue is considered the most important of all arboviruses because of its high burden of disease and social implications. It is an infectious disease caused by any of the four serotypes of the dengue complex, which is transmitted to the human beings through the bite of a mosquito of Aedes genus. Objective: Characterize the clinical manifestations in infants with confirmed dengue. Methods: An observational, descriptive and retrospective study of the clinical manifestations of 150 infants with a diagnosis of dengue confirmed by serology who were hospitalized at Dr. Ángel Arturo Aballí Mother and Child Hospital in the period July-September 2014 was conducted. Results: Infants between 7 and 12 months of age were the most affected (66.8 percent), with a predominance of females (54.0 percent). The main clinical manifestations were: fever, upper respiratory tract manifestations and rash. The appearance of the warning signs coincided with the defervescence of fever in 14 children (9.3 percent) and frequent vomiting and lethargy or irritability were the most repeated symptoms. Just one patient (0.7 percent) presented a clinical picture of shock. Conclusions: During the first year of life, dengue disease can occur in a particular way and resemble any other viral infection. The epidemiological criterion is extremely important, as well as the presence of fever, rash and respiratory manifestations that are not always associated with dengue at other ages(AU)

Imidazolium-modification enhances photocatalytic CO2 reduction on ZnSe quantum dots.

Colloidal photocatalysts can utilize solar light for the conversion of CO2 to carbon-based fuels, but controlling the product selectivity for CO2 reduction remains challenging, in particular in aqueous solution. Here, we present an organic surface modification strategy to tune the product selectivity of colloidal ZnSe quantum dots (QDs) towards photocatalytic CO2 reduction even in the absence of transition metal co-catalysts. Besides H2, imidazolium-modified ZnSe QDs evolve up to 2.4 mmolCO gZnSe -1 (TONQD > 370) after 10 h of visible light irradiation (AM 1.5G, λ > 400 nm) in aqueous ascorbate solution with a CO-selectivity of up to 20%. This represents a four-fold increase in CO-formation yield and 13-fold increase in CO-selectivity compared to non-functionalized ZnSe QDs. The binding of the thiolated imidazolium ligand to the QD surface is characterized quantitatively using 1H-NMR spectroscopy and isothermal titration calorimetry, revealing that a subset of 12 to 17 ligands interacts strongly with the QDs. Transient absorption spectroscopy reveals an influence of the ligand on the intrinsic charge carrier dynamics through passivating Zn surface sites. Density functional theory calculations indicate that the imidazolium capping ligand plays a key role in stabilizing the surface-bound *CO2 - intermediate, increasing the yield and selectivity toward CO production. Overall, this work unveils a powerful tool of using organic capping ligands to modify the chemical environment on colloids, thus enabling control over the product selectivity within photocatalyzed CO2 reduction.

Curing and Healing: What the Gospel Story of the Haemorrhaging Woman Can Teach Nurses.

"Curing" and "healing" are terms frequently used in health care, yet what is actually meant by each? This article asserts that curing pertains exclusively to the corporal while healing is multidimensional-embracing the whole person. Drawing insights from the gospel healing story of the Haemorrhoissa, better known as the bleeding woman or the woman with the issue of blood(Mt 9:20-22; Mk 5:24-34; Lk 8:42-48), this article demonstrates that imitating Christ and partaking in His ministerial mission of healing the sick, demands assisting in the healing process as it expresses authentic Christian love through the patient care provided.

Estrategia de capacitación para el diagnóstico y manejo de arbovirosis en Cienfuegos / Training strategy for the diagnosis and management of arbovirosis in Cienfuegos

RESUMEN Fundamento La introducción de dos nuevas arbovirosis (Chikungunya y Zika), además del dengue, ha creado un nuevo desafío para la salud pública en las Américas. Por ello es importante conocer el grado de asimilación por los profesionales de la salud respecto a las estrategias implementadas para enfrentar dicha problemática. Objetivo describir los resultados de una estrategia de capacitación dirigida a médicos y enfermeros, sobre diagnóstico y manejo clínico de arbovirosis. Métodos estudio cuasi-experimental, del tipo antes y después, desarrollado en Cienfuegos, Cuba, en el período comprendido entre julio de 2018 y enero del 2019. Se tomó una muestra de 95 profesionales, a quienes se aplicaron encuestas antes y después del estudio del documento instructivo (Instrumento para el diagnóstico y la atención a pacientes con sospecha de arbovirosis, publicado por la Organización Panamericana de la Salud) por los participantes; las cuales cubrieron los dominios: cuadro clínico, diagnóstico diferencial, manejo de casos y pronóstico. Resultados se obtuvo un valor medio de respuestas correctas de 70,93. Transcurrido el tiempo destinado a la preparación, y aplicadas nuevas encuestas, la media de respuestas correctas fue de 78,34, diferencia que fue estadísticamente significativa. Se identificaron las principales necesidades de aprendizaje. Conclusión el ejercicio realizado y la evaluación global de las respuestas fueron satisfactorios, según mostraron los valores medios de respuestas correctas antes y después del estudio del documento instructivo en temas de diagnóstico y manejo de arbovirosis.

ABSTRACT Background The introduction of two new arboviruses (Chikungunya and Zika), in addition to dengue, has created a new challenge for public health in the Americas. For this reason, it is important to know the assimilation degree by health professionals regarding the strategies used to face this problem. Objective to describe the results of training strategy aimed at doctors and nurses, on the arboviruses diagnosis and clinical management. Methods a quasi-experimental study, of the before and after type, developed in Cienfuegos, Cuba, in the period between July 2018 and January 2019. A sample of 95 professionals was taken, to whom surveys were applied before and after the study of the instructive document (Instrument for the diagnosis and care of patients with suspected arbovirosis, published by the Pan American Health Organization) by the participants; who covered the domains: clinical picture, differential diagnosis, case management and prognosis. Results a mean value of correct answers of 70.93 was obtained. After the time assigned to preparation, and new surveys were applied, the mean of correct responses was 78.34, a difference that was statistically significant. The main learning needs were identified. Conclusion the exercise carried out and the global evaluation of the responses was satisfactory, as shown by the mean values of correct responses before and after the study of the instructional document on issues of arbovirosis diagnosis and management.

Comportamiento clínico y de laboratorio del choque por dengue en pacientes pediátricos / Clinical and laboratory behavior of dengue shock among pediatric patients

Introducción: El dengue es la enfermedad viral transmitida por artrópodos que más morbilidad y mortalidad ocasiona mundialmente. En el mundo actual, esta arbovirosis se considera la décima causa de muerte sobre todo en edades pediátricas. Objetivo: Caracterizar el comportamiento clínico y de laboratorio del choque por dengue en niños a partir de un año de edad. Métodos: Se realizó un estudio de corte transversal. Se estudiaron 19 pacientes con diagnóstico de choque por dengue. Para el análisis estadístico se utilizaron medidas de resumen como frecuencias, porcentaje, rango, mediana y moda. Resultados: Los signos de choque por dengue predominaron en los pacientes mayores de 5 años, femeninos y blancos, normopesos con antecedentes de salud. La mayoría ingresó al cuarto día; la fiebre fue el principal motivo de ingreso. El aumento progresivo del hematocrito fue el principal signo de alarma, y la hipotensión sin otra manifestación de choque constituyó la manifestación clínica más frecuente. Las soluciones cristaloides fueron las más utilizadas con muy buena respuesta clínica. Conclusiones: Todos los pacientes evolucionaron satisfactoriamente; no hubo ningún fallecimiento por dengue a pesar de que la mayoría fueron hospitalizados durante la fase crítica de la enfermedad, existiendo una identificación adecuada de los signos de alarma, y un adecuado control y tratamiento de las formas clínicas de choque por dengue(AU)

Introduction: Dengue is the arthropod-borne disease causing the highest morbidity and mortality worldwide. This condition is currently considered the tenth leading cause of death in the world, mainly in pediatric ages. Objective: Characterize the clinical and laboratory behavior of dengue shock in children aged one year and over. Methods: A cross-sectional study was conducted of 19 patients diagnosed with dengue shock. Statistical analysis was based on the summary measurements frequency, percentage, range, median and mode. Results: Dengue shock signs prevailed in white female patients aged over five years, of normal weight and with a history of good health. Most were admitted on the fourth day; fever was the main reason for admission. Gradual hematocrit increase was the main warning sign, whereas hypotension without any other shock symptom was the most common clinical manifestation. Crystalloid solutions were the most frequently used, with a very good clinical response. Conclusions: All the patients evolved satisfactorily; no death occurred due to dengue, despite the fact that many patients were admitted during the critical stage of the disease; warning signs were appropriately identified and clinical manifestations of dengue shock were controlled and treated(AU)

Actualización acerca de las semejanzas y diferencias entre el dengue y la COVID-19 / Update on the similarities and differences between dengue and COVID-19

La coexistencia de la COVID-19 y el dengue obliga a médicos y demás personal de la salud a conocer sus particularidades para hacer diagnóstico diferencial. Son enfermedades virales que producen fiebre, afectación general, anorexia, cefalea y, a veces, algunos síntomas digestivos tales como vómitos y diarreas. El propósito de este trabajo es actualizar los conocimientos acerca de ambas enfermedades sobre la base de sus semejanzas y diferencias. El nuevo coronavirus produce tos y otros síntomas respiratorios, lo que no es frecuente en el dengue, pero también los puede producir. La anosmia e hipogeusia son características de la primera, pero algunos enfermos de dengue refieren no encontrar el sabor a los alimentos. La indagación epidemiológica es fundamental para el diagnóstico, pero la prueba de la reacción en cadena de la polimerasa es imprescindible para su confirmación, aunque otros estudios son de utilidad. Ambas tienen un periodo febril y otro crítico y es el síndrome inflamatorio multisistémico la forma grave de la COVID-19 y el choque hipovolémico en el dengue. No tienen una droga antiviral reconocida sino diversos tratamientos dirigidos al huésped principalmente. El dengue no tiene aún una vacuna efectiva como existen para el nuevo coronavirus, entre ellas, las cubanas Soberana 2 y Abdala. La semejanza mayor de ambas enfermedades radica en la necesidad de educar en su conocimiento y manejo al personal sanitario y a toda la población. Evitar el contagio es la mejor prevención en el caso de la COVID-19 y la eliminación de criaderos de mosquitos es imprescindible para evitar las epidemias de dengue (AU)

The coexistence of COVID-19 and dengue forces doctors and other health personnel to know their particularities, in order to make a differential diagnosis. They are viral diseases that produce fever, general affectations, anorexia, headache and sometimes some digestive symptoms such as vomiting and diarrhea. The purpose of this work is to update the knowledge on both diseases based on their similarities and differences. The new coronavirus causes coughing and other respiratory symptoms, which is not common in dengue, but it can also produce them. Anosmia and hypogeusia are characteristic of the COVID-19, but some dengue sufferers report not finding the taste of food. Epidemiological inquiry is essential for diagnosis, but polymerase chain reaction testing is essential for confirmation, although other studies are useful. Both have a febrile and a critical period and it is the multisystem inflammatory syndrome the severe form of COVID-19, and the hypovolemic shock the severe form of dengue. They do not have a recognized antiviral drug but various treatments aimed to the host mainly. Dengue does not yet have an effective vaccine as they exist for the new coronavirus, among them, the Cuban ones called Soberana 2 and Abdala. The greatest similarity of both diseases lies in the need to educate health personnel and all the population in their knowledge and management. Avoiding contagion is the best prevention in the case of COVID-19 and the elimination of mosquito breeding sites is essential to avoid dengue epidemics(AU)