RESUMO
No disponible
Assuntos
Idoso , Feminino , Humanos , Síndrome de Horner/metabolismo , Síndrome de Horner/patologia , Herpes Zoster/complicações , Herpes Zoster/genética , Neuralgia/diagnóstico , Adenocarcinoma/patologia , Síndrome de Pancoast/fisiopatologia , Síndrome de Horner/complicações , Síndrome de Horner/diagnóstico , Herpes Zoster/metabolismo , Herpes Zoster/fisiopatologia , Neuralgia/metabolismo , Adenocarcinoma/cirurgia , Síndrome de Pancoast/metabolismo , Literatura de Revisão como AssuntoAssuntos
Herpes Zoster/complicações , Síndrome de Horner/etiologia , Aciclovir/análogos & derivados , Aciclovir/uso terapêutico , Idoso , Antivirais/uso terapêutico , Braço/inervação , Fibras Autônomas Pré-Ganglionares/virologia , Pálpebras/inervação , Feminino , Gânglios Simpáticos/virologia , Herpes Zoster/diagnóstico , Herpes Zoster/tratamento farmacológico , Herpes Zoster/virologia , Herpesvirus Humano 3/fisiologia , Síndrome de Horner/fisiopatologia , Humanos , Pescoço/inervação , Medula Espinal/virologia , Tórax/inervação , Valaciclovir , Valina/análogos & derivados , Valina/uso terapêuticoAssuntos
Fasciola hepatica/isolamento & purificação , Fasciolíase/sangue , Adulto , Animais , Anti-Helmínticos/uso terapêutico , Benzimidazóis/uso terapêutico , Eosinofilia , Fasciolíase/diagnóstico , Fasciolíase/tratamento farmacológico , Feminino , Humanos , Testes de Função Hepática , Resultado do Tratamento , TriclabendazolRESUMO
No disponible
Assuntos
Adulto , Masculino , Humanos , Síndrome , Didesoxinucleosídeos , Infecções por HIV , Fármacos Anti-HIV , Hipersensibilidade a Drogas , Hipersensibilidade TardiaRESUMO
Using two strains of Salmonella enteritidis, one susceptible and one resistant to ampicillin, we studied the efficacies of ampicillin, gentamicin, ampicillin plus gentamicin, ofloxacin, and cefotaxime for the treatment of experimental salmonella endocarditis. Rabbits were treated for 3 days with dosages of antibiotic selected to achieve concentrations in serum equivalent to those obtained in humans during therapy. Aortic salmonella endocarditis seemed to be very difficult to treat, and all antimicrobial regimens failed to achieve the complete sterilization of cardiac vegetations. In vitro studies did not accurately predict the in vivo response to therapy, and no correlations regarding the synergistic activity of the combination of ampicillin plus gentamicin were observed. For the ampicillin-susceptible S. enteritidis isolate, ampicillin and cefotaxime produced the greatest reduction in the number of organisms in vegetations, with no significant differences between them. For the ampicillin-resistant strain, the combination of ampicillin with gentamicin produced a synergistic effect that was not anticipated by the in vitro studies. Both cefotaxime and ofloxacin were effective in reducing the number of microorganisms in the vegetations, although the reduction produced by cefotaxime was less that that produced against the ampicillin-susceptible strain. Monotherapy with gentamicin exhibited only modest activity against the ampicillin-susceptible S. enteritidis strain.
Assuntos
Resistência a Ampicilina , Ampicilina/farmacologia , Antibacterianos/farmacologia , Anti-Infecciosos/farmacologia , Cefotaxima/farmacologia , Endocardite Bacteriana/tratamento farmacológico , Endocardite Bacteriana/microbiologia , Gentamicinas/farmacologia , Ofloxacino/farmacologia , Infecções por Salmonella , Salmonella enteritidis/efeitos dos fármacos , Animais , Humanos , Testes de Sensibilidade Microbiana , CoelhosRESUMO
Endocarditis is not usually considered a complication of AIDS. Because salmonellal bacteremia is common in HIV-infected patients and because salmonellae have a propensity to adhere to endothelial cells, these patients are at risk of endocarditis and endarteritis. We report two cases of endocarditis due to Salmonella enteritidis and review three previously reported cases. All five patients had underlying heart valve disease and developed fever, breakthrough or relapsing bacteremia, heart murmurs, and cardiac failure; four of five patients were older than 45 years. One patient died, but the other four were successfully treated with beta-lactam agents alone or in combination with aminoglycosides or with ofloxacin (valve replacement was not required). As AIDS patients get older, the number of cases of endocarditis or endarteritis due to Salmonella species may increase, particularly in geographic areas where Salmonella species are prevalent.
