Assuntos
Cistadenocarcinoma Mucinoso/diagnóstico , Cistadenocarcinoma Mucinoso/secundário , Neoplasias Pancreáticas/diagnóstico , Neoplasias Pancreáticas/patologia , Evolução Fatal , Humanos , Neoplasias Hepáticas/secundário , Neoplasias Pulmonares/secundário , Masculino , Pessoa de Meia-Idade , Neoplasias Peritoneais/secundário , Pseudomixoma Peritoneal/etiologiaRESUMO
Focal nodular hyperplasia is a benign liver tumor, that is rare during childhood. We report a new case, exceptional by the short age of the patient, and by the way of this we review the epidemiology, the actual diagnosis criterion and the treatment options.
Assuntos
Hiperplasia Nodular Focal do Fígado/patologia , Humanos , Lactente , MasculinoRESUMO
La hiperplasia nodular focal es una tumoración hepática benigna, de rara presentación en la infancia. Presentamos un nuevo caso, excepcional por la corta edad del paciente, y a propósito de él realizamos una revisión de la epidemiología, de los criterios diagnósticos actuales y de las opciones de tratamiento (AU)
Assuntos
Masculino , Lactente , Humanos , Hiperplasia Nodular Focal do FígadoRESUMO
Nine cases of salivary duct carcinoma were reviewed clinically, histologically and immunohistochemically, with special evaluation of biomarkers with prognostic significance (p53, Ki67, c-erbB-2 and DNA content). Eight tumours occurred in the parotid gland and one in the submandibular gland. The average age of the patients (8 males and 1 female) was 62.8 years (range = 47-74 years). Tumour size ranged from 1 to 6 cm (mean = 3.46 cm). Recurrences were found in 33.3% (3 patients), regional metastases in 44.4% (4 patients) and systemic metastases in 33.3% (3 patients). Three patients died of their disease (median survival = 12.3 months), one is alive with the disease (follow-up of 222 months) and 5 are alive without evidence of disease (mean follow-up of 75 months). p53 protein nuclear immunostaining was positive in 66.6% and c-erbB-2 overexpression was observed in 100% of the tumours. Ki 67 positivity ranged from 6.75% to 47.5% of tumour cells (mean = 21.3%). DNA aneuploidy was found in 4 tumours (44.4%) and DNA diploidy in 5 (55.5%). Our results seem to indicate that Ki67 immunostaining can be useful in the evaluation of the biological behaviour of these tumours, as well as the presence of a high proliferative index of aneuploid cells and the presence of distant metastases.
