Toward Next-Generation Mobile Diagnostics: Near-Field Communication-Powered Electrochemiluminescent Detection.

Mobile phones have been used in combination with point of care (PoC) devices for over a decade now. However, their use seems restricted to the detection of sensing events using the video and camera functions. In contrast, the complementary ability to use mobile phones to power such PoC devices has been largely unexplored. This work demonstrates the proof-of-principle that a smartphone can be used to both power and analyze an electrochemiluminescence (ECL) detection system. A printed device is presented featuring an electrochemical cell connected in series to a rectenna that is able to use the Near Field Communication (NFC, 13.56 MHz) signal to provide the energy needed to generate ECL from Ru(bpy)32+/tri-n-propylamine. The emitted light, the intensity of which is directly proportional to the concentration of the ruthenium complex, can then be captured by the mobile phone camera and analyzed. This work presents the fabrication and the electrical and electrochemical characterization of the device. Effective voltages ranging from 0.90 to 4.50 V have been recorded, depending on the coupling between emitter and receiver, which translate into working electrode potentials ranging from 0.76 up to 1.79 V vs Ag. Detection and quantification limits of 0.64 and 1.52 µM, respectively, have been achieved for Ru(bpy)32+, and linear ranges up to 0.1 mM (red channel) and no less than 1.0 mM (green channel) have been found.

Smartphone-Enabled Personalized Diagnostics: Current Status and Future Prospects.

Smartphones are becoming increasingly versatile thanks to the wide variety of sensor and actuator systems packed in them. Mobile devices today go well beyond their original purpose as communication devices, and this enables important new applications, ranging from augmented reality to the Internet of Things. Personalized diagnostics is one of the areas where mobile devices can have the greatest impact. Hitherto, the camera and communication abilities of these devices have been barely exploited for point of care (POC) purposes. This short review covers the recent evolution of mobile devices in the area of POC diagnostics and puts forward some ideas that may facilitate the development of more advanced applications and devices in the area of personalized diagnostics. With this purpose, the potential exploitation of wireless power and actuation of sensors and biosensors using near field communication (NFC), the use of the screen as a light source for actuation and spectroscopic analysis, using the haptic module to enhance mass transport in micro volumes, and the use of magnetic sensors are discussed.