RESUMO
Language processing involves the interplay of areas in both cerebral hemispheres. Whereas the left temporal lobe is necessary for most language tasks, the right hemisphere seems to be additionally activated during processing of paragraphs and metaphors. We studied the neural correlates of word generation and selection in a sentence context, using functional magnetic resonance imaging (fMRI). Cerebral activation was measured while seven healthy, right handed volunteers read and completed sentence stems, with relatively low Cloze frequency, out loud. During a GENERATION condition, subjects were required to generate a word which completed a sentence stem appropriately. During a DECISION condition, subjects selected and articulated one of two presented terminal words. A READING condition in which subjects read an appropriate completion aloud, served as baseline. When GENERATION was compared to READING or DECISION, the left middle frontal, anterior cingulate, precuneus and right lateral temporal cortex were activated. During DECISION relative to READING, the left inferior frontal and middle/superior temporal cortex bilaterally were activated. The prominent engagement of the right lateral temporal cortex during the GENERATION conditions may reflect the processing of linguistic context, and particularly the activation of multiple meanings in the course of producing an appropriate completion.