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1.
MethodsX ; 10: 102019, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-36845372

RESUMO

EEG hyperscanning refers to recording electroencephalographic (EEG) data from multiple participants simultaneously. Many hyperscanning experimental designs seek to mimic naturalistic behavior, relying on unpredictable participant-generated stimuli. The majority of this research has focused on neural oscillatory activity that is quantified over hundreds of milliseconds or more. This contrasts with traditional event-related potential (ERP) research in which analysis focuses on transient responses, often only tens of milliseconds in duration. Deriving ERPs requires precise time-locking between stimuli and EEG recordings, and thus typically relies on pre-set stimuli that are presented to participants by a system that controls stimulus timing and synchronization with an EEG system. EEG hyperscanning methods typically use separate EEG amplifiers for each participant, increasing cost and complexity - including challenges in synchronizing data between systems. Here, we describe a method that allows for simultaneous acquisition of EEG data from a pair of participants engaged in conversation, using a single EEG system with simultaneous audio data collection that is synchronized with the EEG recording. This allows for the post-hoc insertion of trigger codes so that it is possible to analyze ERPs time-locked to specific events. We further demonstrate methods for deriving ERPs elicited by another person's spontaneous speech, using this setup.•EEG hyperscanning method using a single EEG amplifier•EEG hyperscanning method allowing simultaneous recording of audio data directly into the EEG data file for perfect synchronization•EEG method for naturalistic language and human interaction studies that allows the study of event-related potentials time-locked to spontaneous speech.

2.
Drug Alcohol Rev ; 41(2): 396-405, 2022 02.
Artigo em Inglês | MEDLINE | ID: mdl-34374140

RESUMO

ISSUES: Since the legalisation of cannabis in October 2018, Canada has emerged as a privileged place for research on the properties of this substance, its health effects, but also on its relation with public opinion. However, this scoping review points out the complexity of tracing the evolution of Canadian public opinion on cannabis based on available scientific data. APPROACH: This review follows the guidelines of the Joanna Briggs Institute and summarises more than 60 years of research on Canadians' public opinion, perception and knowledge of cannabis. The study also includes alcohol and tobacco in order to provide a meaningful comparison between substances. KEY FINDINGS: One hundred and sixty-one references selected from over 30 000 studies, with the oldest dating back to 1956, show that public opinion on cannabis is under-studied in Canada compared to alcohol and tobacco. Young people and students are among the most studied populations, unlike Aboriginal communities, immigrants and elderly people. The study reveals the absence of experts in public opinion and political communication, and calls for an imperative need for theoretical frameworks rooted in the work of social scientists. IMPLICATION: These findings do not suggest slowing the rate of publication on alcohol, tobacco, youth or students. Rather, they encourage increasing the rate of publication on other substances used and on other groups also targeted as being particularly at risk of misuse. CONCLUSION: New studies need to measure and contribute to the understanding of Canadian public opinion on cannabis in comparison with public policies currently in place.


Assuntos
Cannabis , Produtos do Tabaco , Adolescente , Idoso , Canadá/epidemiologia , Humanos , Opinião Pública , Nicotiana
3.
Brain Cogn ; 117: 33-40, 2017 10.
Artigo em Inglês | MEDLINE | ID: mdl-28710940

RESUMO

Procedural memory, which is rooted in the basal ganglia, plays an important role in the implicit learning of motor and cognitive skills. Few studies have examined procedural learning in either Tourette syndrome (TS) or Attention Deficit Hyperactivity Disorder (ADHD), despite basal ganglia abnormalities in both of these neurodevelopmental disorders. We aimed to assess procedural learning in children with TS (n=13), ADHD (n=22), and comorbid TS-ADHD (n=20), as well as in typically developing children (n=21). Procedural learning was measured with a well-studied implicit probabilistic sequence learning task, the alternating serial reaction time task. All four groups showed evidence of sequence learning, and moreover did not differ from each other in sequence learning. This result, from the first study to examine procedural memory across TS, ADHD and comorbid TS-ADHD, is consistent with previous findings of intact procedural learning of sequences in both TS and ADHD. In contrast, some studies have found impaired procedural learning of non-sequential probabilistic categories in TS. This suggests that sequence learning may be spared in TS and ADHD, while at least some other forms of learning in procedural memory are impaired, at least in TS. Our findings indicate that disorders associated with basal ganglia abnormalities do not necessarily show procedural learning deficits, and provide a possible path for more effective diagnostic tools, and educational and training programs.


Assuntos
Transtorno do Deficit de Atenção com Hiperatividade/psicologia , Aprendizagem Seriada/fisiologia , Síndrome de Tourette/psicologia , Adolescente , Transtorno do Deficit de Atenção com Hiperatividade/complicações , Criança , Feminino , Humanos , Masculino , Tempo de Reação/fisiologia , Síndrome de Tourette/complicações
4.
Brain Connect ; 6(10): 747-758, 2016 12.
Artigo em Inglês | MEDLINE | ID: mdl-27784161

RESUMO

Healthy aging has been associated with a global reduction in white matter integrity, which is thought to reflect cognitive decline. The present study aimed to investigate this reduction over a broad range of the life span, using diffusion tensor imaging analyzed with conditional inference random forest modeling (CForest). This approach is sensitive to subtle and potentially nonlinear effects over the age continuum and was used to characterize the progression of decline in greater detail than has been possible in the past. Data were collected from 45 healthy individuals ranging in age from 19 to 67 years. Fractional anisotropy (FA) was estimated using probabilistic tractography for a number of major tracts across the brain. Age coincided with a nonlinear decrease in FA, with onset beginning at ∼30 years of age and the steepest declines occurring later in life. However, several tracts showed a transient increase before this decline. The progression of decline varied by tract, with steeper but later decline occurring in more anterior tracts. Finally, strongly right-handed individuals demonstrated relatively preserved FA until more than a decade following the onset of decline of others. These results demonstrate that using a novel, nonparametric analysis approach, previously reported reductions in FA with healthy aging were confirmed, while at the same time, new insight was provided into the onset and progression of decline, with evidence suggesting increases in integrity continuing into adulthood.


Assuntos
Imagem de Tensor de Difusão/métodos , Substância Branca/diagnóstico por imagem , Adulto , Fatores Etários , Idoso , Envelhecimento , Anisotropia , Encéfalo/anatomia & histologia , Encéfalo/fisiologia , Transtornos Cognitivos/diagnóstico por imagem , Transtornos Cognitivos/fisiopatologia , Imagem de Difusão por Ressonância Magnética/métodos , Feminino , Voluntários Saudáveis , Humanos , Masculino , Pessoa de Meia-Idade
5.
Psychophysiology ; 52(1): 124-39, 2015 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-25132114

RESUMO

In the analysis of psychological and psychophysiological data, the relationship between two variables is often assumed to be a straight line. This may be due to the prevalence of the general linear model in data analysis in these fields, which makes this assumption implicitly. However, there are many problems for which this assumption does not hold. In this paper, we show that, in the analysis of event-related potential (ERP) data, the assumption of linearity comes at a cost and may significantly affect the inferences drawn from the data. We demonstrate why the assumption of linearity should be relaxed and how to model nonlinear relationships between ERP amplitudes and predictor variables within the familiar framework of generalized linear models, using regression splines and mixed-effects modeling.


Assuntos
Eletroencefalografia/estatística & dados numéricos , Potenciais Evocados/fisiologia , Rememoração Mental/fisiologia , Modelos Estatísticos , Adulto , Feminino , Humanos , Dinâmica não Linear , Análise de Regressão , Adulto Jovem
6.
Neuroimage ; 101: 159-67, 2014 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-24999037

RESUMO

Motor imagery (MI) may be effective as an adjunct to physical practice for motor skill acquisition. For example, MI is emerging as an effective treatment in stroke neurorehabilitation. As in physical practice, the repetitive activation of neural pathways during MI can drive short- and long-term brain changes that underlie functional recovery. However, the lack of feedback about MI performance may be a factor limiting its effectiveness. The provision of feedback about MI-related brain activity may overcome this limitation by providing the opportunity for individuals to monitor their own performance of this endogenous process. We completed a controlled study to isolate neurofeedback as the factor driving changes in MI-related brain activity across repeated sessions. Eighteen healthy participants took part in 3 sessions comprised of both actual and imagined performance of a button press task. During MI, participants in the neurofeedback group received source level feedback based on activity from the left and right sensorimotor cortex obtained using magnetoencephalography. Participants in the control group received no neurofeedback. MI-related brain activity increased in the sensorimotor cortex contralateral to the imagined movement across sessions in the neurofeedback group, but not in controls. Task performance improved across sessions but did not differ between groups. Our results indicate that the provision of neurofeedback during MI allows healthy individuals to modulate regional brain activity. This finding has the potential to improve the effectiveness of MI as a tool in neurorehabilitation.


Assuntos
Lateralidade Funcional/fisiologia , Neuroimagem Funcional/métodos , Imaginação/fisiologia , Magnetoencefalografia/métodos , Destreza Motora/fisiologia , Neurorretroalimentação/fisiologia , Córtex Sensório-Motor/fisiologia , Adulto , Ondas Encefálicas/fisiologia , Eletromiografia , Potenciais Evocados/fisiologia , Feminino , Humanos , Masculino , Distribuição Aleatória , Adulto Jovem
7.
J Cogn Neurosci ; 24(5): 1205-23, 2012 May.
Artigo em Inglês | MEDLINE | ID: mdl-21981676

RESUMO

We investigated the influence of English proficiency on ERPs elicited by lexical semantic violations in English sentences, in both native English speakers and native Spanish speakers who learned English in adulthood. All participants were administered a standardized test of English proficiency, and data were analyzed using linear mixed effects (LME) modeling. Relative to native learners, late learners showed reduced amplitude and delayed onset of the N400 component associated with reading semantic violations. As well, after the N400 late learners showed reduced anterior negative scalp potentials and increased posterior potentials. In both native and late learners, N400 amplitudes to semantically appropriate words were larger for people with lower English proficiency. N400 amplitudes to semantic violations, however, were not influenced by proficiency. Although both N400 onset latency and the late ERP effects differed between L1 and L2 learners, neither correlated with proficiency. Different approaches to dealing with the high degree of correlation between proficiency and native/late learner group status are discussed in the context of LME modeling. The results thus indicate that proficiency can modulate ERP effects in both L1 and L2 learners, and for some measures (in this case, N400 amplitude), L1-L2 differences may be entirely accounted for by proficiency. On the other hand, not all effects of L2 learning can be attributed to proficiency. Rather, the differences in N400 onset and the post-N400 violation effects appear to reflect fundamental differences in L1-L2 processing.


Assuntos
Mapeamento Encefálico , Potenciais Evocados/fisiologia , Multilinguismo , Semântica , Comportamento Verbal/fisiologia , Aprendizagem Verbal/fisiologia , Adolescente , Adulto , Análise de Variância , Eletroencefalografia , Feminino , Lateralidade Funcional , Humanos , Julgamento , Modelos Lineares , Masculino , Pessoa de Meia-Idade , Estimulação Luminosa , Tempo de Reação/fisiologia , Inquéritos e Questionários , População Branca , Adulto Jovem
8.
Res Dev Disabil ; 32(6): 2362-75, 2011.
Artigo em Inglês | MEDLINE | ID: mdl-21840165

RESUMO

The Procedural Deficit Hypothesis (PDH) posits that Specific Language Impairment (SLI) can be largely explained by abnormalities of brain structures that subserve procedural memory. The PDH predicts impairments of procedural memory itself, and that such impairments underlie the grammatical deficits observed in the disorder. Previous studies have indeed reported procedural learning impairments in SLI, and have found that these are associated with grammatical difficulties. The present study extends this research by examining consolidation and longer-term procedural sequence learning in children with SLI. The Alternating Serial Reaction Time (ASRT) task was given to children with SLI and typically developing (TD) children in an initial learning session and an average of three days later to test for consolidation and longer-term learning. Although both groups showed evidence of initial sequence learning, only the TD children showed clear signs of consolidation, even though the two groups did not differ in longer-term learning. When the children were re-categorized on the basis of grammar deficits rather than broader language deficits, a clearer pattern emerged. Whereas both the grammar impaired and normal grammar groups showed evidence of initial sequence learning, only those with normal grammar showed consolidation and longer-term learning. Indeed, the grammar-impaired group appeared to lose any sequence knowledge gained during the initial testing session. These findings held even when controlling for vocabulary or a broad non-grammatical language measure, neither of which were associated with procedural memory. When grammar was examined as a continuous variable over all children, the same relationships between procedural memory and grammar, but not vocabulary or the broader language measure, were observed. Overall, the findings support and further specify the PDH. They suggest that consolidation and longer-term procedural learning are impaired in SLI, but that these impairments are specifically tied to the grammatical deficits in the disorder. The possibility that consolidation and longer-term learning are problematic in the disorder suggests a locus of potential study for therapeutic approaches. In sum, this study clarifies our understanding of the underlying deficits in SLI, and suggests avenues for further research.


Assuntos
Transtornos do Desenvolvimento da Linguagem/diagnóstico , Linguística , Transtornos da Memória/diagnóstico , Memória/fisiologia , Criança , Feminino , Humanos , Transtornos do Desenvolvimento da Linguagem/fisiopatologia , Testes de Linguagem , Masculino , Transtornos da Memória/fisiopatologia , Valor Preditivo dos Testes , Diferencial Semântico , Aprendizagem Verbal/fisiologia , Vocabulário
9.
Neurobiol Dis ; 20(2): 360-71, 2005 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-16242641

RESUMO

In recent years, several lines of evidence have shown an increase in Parkinson's disease (PD) prevalence in rural environments where pesticides are widely used. Paraquat (PQ--herbicide) and maneb (MB--fungicide) are among the compounds suspected to induce neuronal degeneration and motor deficits characteristics of PD. Here, we investigated the effects of PQ and MB on dopaminergic (DA) neuron-glia cultures and in vivo in young adult rats. In vitro, PQ led to a loss of DA as compared to non-DA neurons and microglial activation in a dose-dependent manner. Addition of MB had no further effect nor did it lead to microglial activation when used alone. In vivo, 2-month old young adult rats were subjected to intraperitoneal injections of vehicle (n = 4), PQ alone (n = 8), or PQ in combination with MB (n = 8) twice a week for 4 weeks and were sacrificed the day following the last injection. Significant loss of nigral DA neurons was observed in both treatment groups, but a significant decrease in striatal DA fibers was not found. Microglial activation was seen in the nigra of rats subjected to PQ with or without MB. Behavioral analyses demonstrated a mixed pattern of motor impairments, which may have been related to early effects of nigral DA neuronal loss or systemic effects associated with MB exposure in addition to PQ. These results indicate that exposure to PQ with or without MB induces neurodegeneration which might occur via an early inflammatory response in young adult animals.


Assuntos
Maneb/toxicidade , Paraquat/toxicidade , Transtornos Parkinsonianos/induzido quimicamente , Substância Negra/efeitos dos fármacos , Idade de Início , Animais , Células Cultivadas , Técnicas de Cocultura , Modelos Animais de Doenças , Dopamina/metabolismo , Relação Dose-Resposta a Droga , Encefalite/induzido quimicamente , Encefalite/patologia , Encefalite/fisiopatologia , Fungicidas Industriais/toxicidade , Gliose/induzido quimicamente , Gliose/patologia , Gliose/fisiopatologia , Herbicidas/toxicidade , Masculino , Microglia/efeitos dos fármacos , Microglia/patologia , Degeneração Neural/induzido quimicamente , Degeneração Neural/patologia , Degeneração Neural/fisiopatologia , Neurônios/efeitos dos fármacos , Neurônios/patologia , Transtornos Parkinsonianos/patologia , Transtornos Parkinsonianos/fisiopatologia , Ratos , Ratos Sprague-Dawley , Ratos Wistar , Substância Negra/patologia , Substância Negra/fisiopatologia
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