RESUMO
El adenocarcinoma villoglandular de cérvix uterino es una neoplasia poco frecuente, con unas características histológicas y clínicas diferentes de otros tipos de adenocarcinomas de cérvix. No fue introducido en la clasificación de la Organización Mundial de la Salud hasta 1994. El tratamiento de este tipo de tumor debe ser, en la medida de lo posible, conservador si la paciente desea preservar su fertilidad, pues presenta buen pronóstico. Los hallazgos microscópicos son típicos e incluyen: crecimiento exofítico, superficie de aspecto papilar y de leve a moderada atipia nuclear. Presentamos 4 casos clínicos de esta entidad, uno de ellos con progresión y comportamiento agresivo (AU)
Villoglandular adenocarcinoma of the uterine cervix is a rare neoplasm, with histological and clinical features that distinguish it from other types of cervical adenocarcinomas. Until 1994, this entity was not included with the cervical carcinoma classification of the World Health Organization. The prognosis of this tumor is favorable and consequently treatment should be conservative as far as possible if the patient wishes to preserve fertility. Microscopic findings are typical and include exophytic growth, papillary surface and small-to-moderate nuclear atypia. We describe four cases of villoglandular adenocarcinoma, one of which showed aggressive progression (AU)
Assuntos
Humanos , Feminino , Adulto , Pessoa de Meia-Idade , Neoplasias do Colo do Útero/complicações , Neoplasias do Colo do Útero/diagnóstico , Ovariectomia/métodos , Síndrome de Meigs/diagnóstico , Síndrome de Meigs/cirurgia , Colposcopia/métodos , Neoplasias do Colo do Útero , Biópsia/métodosRESUMO
La enfermedad de Bowen vulvar o neoplasia vulvar intraepitelial (VIN) es una lesión preinvasora en los genitales externos. La VIN de etiología viral está relacionada con la infección por virus del papiloma humano (VPH) (principalmente los serotipos 16 y 18), sobre todo a edades tempranas y en relación con cambios en la conducta sexual. Presentamos el caso clínico que corresponde a una paciente joven, portadora del VPH 16 y en control por neoplasia intraepitelial de cuello uterino tipo III (CIN III) tras una conización, que desarrolló una VIN extensa. Se realizó tratamiento quirúrgico (ninfectomía) sin recidiva a los 3 años y con buen resultado estético (AU)
Bowens disease of the vulva, also called vulvar intraepithelial neoplasia (VIN), is considered a premalignant lesion of the external genitalia. VIN of viral etiology is most often associated with human papillomavirus (HPV) subtypes 16 and 18 and typically occurs in younger premenopausal women. The main risk factor for HPV acquisition is sexual activity. We report the case of a young patient, a carrier of HPV subtype 16, with cervical intraepithelial neoplasia grade 3, who developed severe VIN. Wide local excision of the labia minora was performed. The cosmetic results were satisfactory and the patient has had no relapses after 3 years of follow-up (AU)
Assuntos
Humanos , Feminino , Adulto , Doença de Bowen/complicações , Doença de Bowen/diagnóstico , Doença de Bowen/terapia , Neoplasias Vulvares/complicações , Neoplasias Vulvares/diagnóstico , Imuno-Histoquímica , Doença de Bowen/etiologia , Doença de Bowen/fisiopatologia , Infecções por Papillomavirus/complicações , Infecções por Papillomavirus/patologia , 31574/complicações , 31574/patologia , Diagnóstico DiferencialRESUMO
Coexistence of a hepatocellular carcinoma with pregnancy is extremely rare. The authors present the case of an African woman positive for hepatitis B surface antigen and referred to our hospital for suspected cervical incompetence in which a surgically unapproachable hepatocellular carcinoma was diagnosed. The patient refused termination of pregnancy or liver transplantation because of religious beliefs. In this case, the authors had the opportunity to follow the growth of the mass throughout the pregnancy and puerperium.