RESUMO
Two new lindenane sesquiterpenes were obtained from the roots of Lindera myrrha. These compounds were structurally elucidated by HRMS data, extensive NMR analyses, and comparison between experimental and theoretical 13C-NMR data. Myrrhalindenane A is the first monomeric seco-d lindenane displaying a non-rearranged, cyclohexanic C-ring. Myrrhalindenane B is the second occurrence of an angular lindenane-sesquiterpene related to a C6-C7 lactonization.
Assuntos
Lindera/química , Sesquiterpenos/isolamento & purificação , Teoria da Densidade Funcional , Espectroscopia de Ressonância Magnética , Estrutura Molecular , Raízes de Plantas/química , Sesquiterpenos/químicaRESUMO
Interactions of dimethyl sulfoxide with carbon dioxide and water molecules which induce 18 significantly stable complexes are thoroughly investigated. An addition of CO2 or H2 O molecules into the DMSOâ¯1CO2 and DMSOâ¯1H2 O systems leads to an increase in the stability of the resulting complexes, in which it is larger for a H2 O addition than a CO2 . The overall stabilization energy of the DMSOâ¯1,2CO2 is mainly contributed by the S=Oâ¯C Lewis acid-base interaction, whereas the O - Hâ¯O hydrogen bond plays a significant role in stabilizing complexes of DMSOâ¯1,2H2 O and DMSOâ¯1CO2 â¯1H2 O. Remarkably, the complexes of DMSOâ¯2H2 O are found to be more stable than DMSOâ¯1CO2 â¯1H2 O and DMSOâ¯2CO2 . The level of the cooperativity of multiple interactions in ternary complexes tends to decrease in going from DMSOâ¯2H2 O to DMSOâ¯1CO2 â¯1H2 O and finally to DMSOâ¯2CO2 . It is generally found that the red shift of the O - H bond involved in an O - Hâ¯O hydrogen bond increases while the blue shift of a C - H bond in a C - Hâ¯O hydrogen bond decreases when a cooperative effect occurs in ternary complexes as compared to those of the corresponding binary complexes. © 2018 Wiley Periodicals, Inc.
RESUMO
The methanol extract of Olax imbricata roots afforded one new sesquiterpenoid tropolone and three new 1,2,3,4-tetrahydronaphthalene derivatives, olaximbrisides A-D (1-4). Their structures were determined by 1D and 2D NMR experiments in combination of HRESIMS. The relative configurations were assigned by the NOESY experiments. The absolute configurations were established by a combination of X-ray diffraction analysis and electronic circular dichroism (ECD) experiments. All isolated compounds were evaluated for their cytotoxic effects against some cancer cell lines. Among them, compound 1 exhibited the cytotoxicities against MCF-7, HepG2 and LU cell lines with IC50 values of 16.3, 34.3 and 8.0⯵M, respectively.