[To the mechanism of enhancing the activity of serum and hepatic sorbitol dehydrogenase in rats fed excess sweetener sorbitol].

One-month rats were randomized to a diet containing sorbitol (SOR) (54%), saccharose (SACCH) (54%) or that containing SOR (27%) and SACCH (27%). They were kept on the diets for 1 or 3 months. At the age of 2 and 4 months, the rats were returned to the routine diet of a vivarium. The experiments were terminated when the rats were aged 2, 4, and 7 months. In all seasons, the monthly diets containing 27% and 54% of SOR increased the serum activity of sortibol dehydrogenase (SDH) by several and tens of times. The 3-month diet produced the same effect. It suddenly turned out that the 54% SACCH diet also increased SDH activity, but to a lesser extent than a combination of 27 SOR and 27% SACCH, and by tens of times less than the 54% SOR diet. Comparison of three diets showed the same relationship between the increases in SDH activity in the liver. With excess dietary SOR, a very high increase was first found in serum and hepatic SOD activity by an induction mechanism.

[Energy metabolism in structures of the visual analyzer and neurons of the sympathetic ganglion after irradiation of the eye with low-intensity infrared laser radiation in the near-spectrum region]. / Sostoianie énergeticheskogo obmena v strukturakh zritel'nogo analizatora i neironakh simpaticheskogo gangliia posle oblucheniia glaza nizkointensivnym infrakrasnym lazernym izlucheniem blizhnei oblasti spektra.

After irradiation of one eye by low-intensive infrared laser with near spectral region within 5 and 20 min an increase in aerobic oxidation (activation of glutamate- and succinate dehydrogenases, decrease in activity of lactate dehydrogenase and in content of lactate) as well as alterations in the antioxidant activity were observed in structures of both eyes (irradiated and untreated), in visual cortex of both hemispheres and in neurocytes of upper cervical sympathetic ganglions. These results suggest that generalized metabolic reactions are developed in a body in response to laser irradiation. Mechanism of these reactions appears to involve not only the neuro-reflex pathways but it related also to the direct effect of the radiation on structures of eye and brain. The low-intensive laser radiation penetrated into brain through eye retrobulbar tissues and bones.

[The role of the modification of cyclic purine nucleotide molecule in the regulation of platelet acid glycosidase activity]. / Rol' modifikatsii molekuly purinovogo tsiklonukleotida v reguliatsii aktivnosti kisloi glikozidazy trombotsitov.

3'5'-cGMP activated beta-glucuronidase, beta-galactosidase, beta-glucosidase and N-acetyl-beta-glucosaminidase in blood platelets, while 2'3'-cGMP, 3,5'-cGMP, N2O2'-dipalmitoyl and 5'-GMP did not affect the activity of these glycosidases. The guanylate cyclase system appears to be involved in activation of blood platelets glycosidases since it is well known that 3'5'-cGMP activates the thrombocyte protein kinase.