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2.
J Natl Compr Canc Netw ; 22(1)2024 02.
Artigo em Inglês | MEDLINE | ID: mdl-38394779

RESUMO

Infant-type hemispheric glioma (IHG) is a rare pediatric brain tumor with variable response to chemotherapy and radiotherapy. Molecular insights into IHG can be useful in identifying potentially active targeted therapy. A male fetus was found to have congenital hydrocephalus at the gestational age of 37 weeks. Fetal MRI showed a 2.6 × 2.0-cm tumor located at the frontal horn of the left lateral ventricle, involving the left basal nuclei and thalamus. Tumor biopsy at the age of 2 days revealed an IHG consisting of spindle tumor cells with strong expression of GFAP and ALK. Targeted RNA sequencing detected a novel fusion gene of SOX5::ALK. After initial chemotherapy with cyclophosphamide, carboplatin, and etoposide for 2 cycles, the tumor size progressed markedly and the patient underwent a subtotal resection of brain tumor followed by treatment with lorlatinib, an ALK tyrosine kinase inhibitor with central nervous system (CNS) activity. After 3 months of treatment, reduction of tumor size was observed. After 14 months of treatment, partial response was achieved, and the infant had normal growth and development. In conclusion, we identified a case of congenital IHG with a novel SOX5::ALK fusion that had progressed after chemotherapy and showed partial response and clinical benefit after treatment with the CNS-active ALK inhibitor lorlatinib.


Assuntos
Aminopiridinas , Neoplasias Encefálicas , Carcinoma Pulmonar de Células não Pequenas , Glioma , Lactamas , Neoplasias Pulmonares , Pirazóis , Lactente , Criança , Masculino , Humanos , Recém-Nascido , Neoplasias Pulmonares/tratamento farmacológico , Carcinoma Pulmonar de Células não Pequenas/tratamento farmacológico , Quinase do Linfoma Anaplásico/genética , Lactamas Macrocíclicas/uso terapêutico , Inibidores de Proteínas Quinases/uso terapêutico , Neoplasias Encefálicas/terapia , Neoplasias Encefálicas/tratamento farmacológico , Glioma/terapia , Glioma/tratamento farmacológico , Fatores de Transcrição SOXD
4.
Int Immunopharmacol ; 127: 111455, 2024 Jan 25.
Artigo em Inglês | MEDLINE | ID: mdl-38157699

RESUMO

BACKGROUND: Immune-mediated diseases (IMDs) after nucleic acid-based vaccines have been sporadically reported since their introduction during the worldwide COVID-19 crisis. Confirming their cause-effect association remains challenging. We analysed the effects of AZD1222 (ChAdOx1 nCoV-19), BNT-162b2, and/or mRNA-1273 on the development &/or deterioration of IMDs in terms of the time of clinical onsets of IMDs after exposure to these vaccines. METHODS: We retrospectively reviewed 78 in-patients in Taipei Veterans General Hospital, who presented with IMDs within 120 days after receiving AZD1222, BNT-162b2, &/or mRNA-1273 vaccinations in Taiwan from May 2021 to April 2022. The duration from inoculation to development of IMD was analysed by two-tailed Kolmogorov-Smirnov (K-S) test for goodness of fit. RESULTS: The average time to new IMDs or flare-up of the diseases following vaccinations was 36 ± 26 days for all 91 events in these 78 patients. The onset time of IMDs after vaccinations was not haphazard as analysed by two-tailed K-S test for overall 91 events (40 new and 51 deteriorating episodes, p < 0.001). The IMDs presenting as non-connective tissue diseases (non-CTDs) have a shorter duration of incubation after vaccinations than those of CTDs (<14.7 days, 95 % confidence interval [CI], 3.0 to 26.4, p = 0.014). Furthermore, systemic vasculitis and type 2 inflammatory diseases were observed exclusively in those receiving AZD1222. CONCLUSION: AZD1222, BNT-162b2, or mRNA-1273 influence the activities of IMDs in ways yet to be explored. High index of suspicion to IMDs after nucleic acid-based vaccine inoculation against COVID-19 may be important for primary care physicians.


Assuntos
COVID-19 , Doenças do Sistema Imunitário , Humanos , ChAdOx1 nCoV-19 , Vacina BNT162 , Vacina de mRNA-1273 contra 2019-nCoV , Estudos Retrospectivos , Vacinação/efeitos adversos , COVID-19/prevenção & controle , Vacinas Baseadas em Ácido Nucleico
5.
Clin Implant Dent Relat Res ; 23(6): 833-841, 2021 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-34405532

RESUMO

BACKGROUND: Large antroliths and those located adjacent to the sinus floor can affect clinical interventions and increase the difficulty of implant placement performed simultaneously with osteotome sinus floor elevation surgery. PURPOSE: This retrospective study investigated the clinical outcomes of implants placed simultaneously with osteotome sinus floor elevation subjacent to maxillary antroliths. MATERIAL AND METHODS: Twenty implants inserted subjacent to or intruding into the antrolith after sinus floor elevation were evaluated in 18 patients. Cone-beam computed tomography (CBCT) was used to measure antrolith size and membrane thickness at sites of osteotome sinus floor elevation. Periapical radiographs were used to assess the height of grafted bone. Generalized estimating equation (GEE) analysis was performed to correlate the occurrence of antroliths with patient background characteristics and dental outcomes, based on a sample population of 239, among whom 33 presented antroliths. RESULTS: The 20 implants remained clinically stable over a mean follow-up period of 42.4 months. The mean thickness of the sinus membrane at osteotome sites was 5.4 ± 3.3 mm. None of the cases presented sinus membrane perforation or sinus symptoms following osteotome intervention. The mean gain in the height of grafted sinus bone was 4.0 ± 1.4 mm at the last follow-up. The occurrence of antroliths was higher among females and the elderly (>49 years old). The multivariable GEE analysis showed that the adjusted odds ratio for the occurrence of antroliths with root canal fillings was significantly lower than those without root canal fillings (odds ratio = 0.33; 95% confidence interval = 0.11-0.96). CONCLUSION: Our findings indicate that osteotome sinus floor elevation is a surgical procedure with a risk <17%. Thorough planning based on CBCT and careful management during surgery can eliminate the negative effects of antroliths on implant performance.


Assuntos
Implantes Dentários , Levantamento do Assoalho do Seio Maxilar , Idoso , Implantação Dentária Endóssea/efeitos adversos , Implantes Dentários/efeitos adversos , Feminino , Humanos , Maxila/diagnóstico por imagem , Maxila/cirurgia , Seio Maxilar/diagnóstico por imagem , Seio Maxilar/cirurgia , Pessoa de Meia-Idade , Estudos Retrospectivos , Levantamento do Assoalho do Seio Maxilar/efeitos adversos , Resultado do Tratamento
6.
Ann Plast Surg ; 82(1S Suppl 1): S130-S135, 2019 01.
Artigo em Inglês | MEDLINE | ID: mdl-30422845

RESUMO

Locked thumb metacarpophalangeal joint caused by entrapment of the sesamoid bone is an uncommon entity. The intact volar plate, strong ligamentous attachment between the sesamoid bone and the joint, and altered axis of inserted muscle all contribute to failure of closed reduction. The patient's history, clinical presentation, and plain radiographic findings are all important clues to diagnosing this rare disease. We describe 2 patients with a similar mechanism of injury, where the sesamoid bones were displaced into the thumb metacarpophalangeal joint causing lock thumb. The anatomy, pathophysiology, and surgical management of the patients are also described and discussed. Both patients were successfully treated with meticulous open reduction.


Assuntos
Traumatismos em Atletas/complicações , Articulação Metacarpofalângica/cirurgia , Ossos Sesamoides/lesões , Polegar/lesões , Dedo em Gatilho/cirurgia , Adolescente , Adulto , Traumatismos em Atletas/diagnóstico por imagem , Basquetebol/lesões , Seguimentos , Fratura-Luxação/diagnóstico por imagem , Fratura-Luxação/cirurgia , Fraturas Ósseas/complicações , Fraturas Ósseas/diagnóstico por imagem , Humanos , Escala de Gravidade do Ferimento , Masculino , Articulação Metacarpofalângica/diagnóstico por imagem , Articulação Metacarpofalângica/fisiopatologia , Procedimentos Ortopédicos/métodos , Radiografia/métodos , Amplitude de Movimento Articular/fisiologia , Recuperação de Função Fisiológica , Estudos de Amostragem , Resultado do Tratamento , Dedo em Gatilho/diagnóstico por imagem , Dedo em Gatilho/etiologia
7.
Microsurgery ; 39(2): 150-155, 2019 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-30496608

RESUMO

INTRODUCTION: The number of perforators required for safe perfusion remains under debate. This study aimed to determine whether a single- or multiple-perforator-based anterolateral thigh flap yields better flap outcomes in head and neck reconstruction. PATIENTS AND METHODS: Between August 2012 and July 2016, 180 men and 4 women with a mean age of 52.8 ± 9.8 years underwent head and neck anterolateral thigh flap reconstruction for oncologic defect in 181 cases, plate exposure in two cases, and trismus release in one case. The flap was patched for inner or external lining, folded for through-through defect, or tubed for cervical esophageal reconstruction. Of 184 flaps, 136 (73.9%) were based on multiple perforators (range, 2-5 perforators), whereas 48 (26.1%) were based on a single perforator. The demographics, operative findings, and flap outcomes were compared. RESULTS: The prevalence of systemic diseases between groups was comparable. The mean flap size in the single-perforator group was smaller (92.8 ± 36.8 vs. 140.5 ± 99.9 cm2 , P < .0001). Twenty-one flaps (11.4%) required emergency take-back and 13 (61.9%) were successfully salvaged. Eight flaps failed, yielding a 95.7% flap survival rate. The single-perforator group had a significantly higher rate of emergency take-back for vascular compromise (8/48 (16.7%) vs. 8/136 (5.9%), P = .035), a decreased salvage success rate (2/8 (25.0%) vs. 11/13 (84.6%), P = .018), and a corresponding lower flap survival rate (42/48 (87.5%) vs. 134/136 (98.5%), P = .004). CONCLUSION: Whenever possible, we recommend including multiple cutaneous perforators in anterolateral thigh flaps to yield better flap outcomes in head and neck reconstruction.


Assuntos
Carcinoma de Células Escamosas/cirurgia , Neoplasias de Cabeça e Pescoço/cirurgia , Retalho Perfurante/transplante , Procedimentos de Cirurgia Plástica/métodos , Idoso , Carcinoma de Células Escamosas/patologia , China , Estudos de Coortes , Feminino , Seguimentos , Rejeição de Enxerto , Sobrevivência de Enxerto , Neoplasias de Cabeça e Pescoço/patologia , Hospitais Universitários , Humanos , Masculino , Pessoa de Meia-Idade , Retalho Perfurante/irrigação sanguínea , Estudos Retrospectivos , Coxa da Perna/cirurgia , Cicatrização/fisiologia
9.
Bioresour Technol ; 128: 297-304, 2013 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-23201511

RESUMO

A continuous acid-catalyzed steam explosion pretreatment process and system to produce cellulosic ethanol was developed at the pilot-scale. The effects of the following parameters on the pretreatment efficiency of rice straw feedstocks were investigated: the acid concentration, the reaction temperature, the residence time, the feedstock size, the explosion pressure and the screw speed. The optimal presteaming horizontal reactor conditions for the pretreatment process are as follows: 1.7 rpm and 100-110 °C with an acid concentration of 1.3% (w/w). An acid-catalyzed steam explosion is then performed in the vertical reactor at 185 °C for 2 min. Approximately 73% of the total saccharification yield was obtained after the rice straw was pretreated under optimal conditions and subsequent enzymatic hydrolysis at a combined severity factor of 0.4-0.7. Moreover, good long-term stability and durability of the pretreatment system under continuous operation was observed.


Assuntos
Carboidratos/síntese química , Celulase/química , Celulose/química , Etanol/síntese química , Oryza/química , Componentes Aéreos da Planta/química , Vapor , Catálise , Celulose/isolamento & purificação , Projetos Piloto
10.
Transplantation ; 93(3): 265-71, 2012 Feb 15.
Artigo em Inglês | MEDLINE | ID: mdl-22198494

RESUMO

BACKGROUND: We tested the effectiveness of ischemic postconditioning (iPoC) in mitigating ischemia-reperfusion (I/R) injury of liver and the mechanism involves inhibiting the opening of the mitochondrial permeability transition pore (mPTP). METHODS: iPoC, performed by three cycles of 1 min I/R of the liver, was tested on a partial liver I/R model on rats. The serum alanine transaminase levels, terminal deoxynucleotidyl transferase dUTP nick-end labeling staining, cytochrome c release, the formation of 4-hydroxy-2-nonnenal-modified proteins, and mitochondrial membrane potential (Δψm) were measured. Atractyloside (ATR) and NIM811, which modify the opening of mPTP, were administered in selected groups. RESULTS: iPoC, and NIM811, diminished the elevation of serum alanine transaminase level after I/R injury (174.0±28.3 U/L for iPoC; 94.3±25.4 U/L for control+NIM811) when compared with others (416.3±16.7 U/L for control, 557.0±86.7 U/L for iPoC+ATR, P<0.05). The expressions of cytosolic cytochrome c after I/R injury were decreased in iPoC and control+NIM811 groups when compared with others. After I/R, the apoptosis and the 4-hydroxy-2-nonnenal-modified proteins were attenuated in iPoC group when compared (apoptotic counts/50 HPF: 723.3±98.7 for iPoC, 1274±201.2 for control, 1057.6±39 for iPoC+ATR, P<0.05). The Δψm measured by flow cytometry was better preserved in iPoC and NIM811 groups. CONCLUSIONS: iPoC attenuated cell deaths after I/R injury of liver. The protective effects were negated by the addition of ATR--a mPTP opener--and mimicked by injection of NIM811--a mPTP opening inhibitor. The study indicated iPoC conferred protection by modulating mPTP.


Assuntos
Pós-Condicionamento Isquêmico , Fígado/irrigação sanguínea , Proteínas de Transporte da Membrana Mitocondrial/fisiologia , Traumatismo por Reperfusão/prevenção & controle , Alanina Transaminase/sangue , Animais , Ciclosporina/farmacologia , Citocromos c/metabolismo , Heme Oxigenase (Desciclizante)/biossíntese , Masculino , Poro de Transição de Permeabilidade Mitocondrial , Estresse Oxidativo , Ratos , Ratos Wistar
11.
Neuropsychologia ; 49(5): 1373-1377, 2011 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-21241722

RESUMO

Action observation automatically activates corresponding motor representations in the observer, which is essential in coordinating actions with others. It is assumed that this co-representation system is activated by biological agents only. However, we often identify with biological agents, whereas this is not the case for non-biological agents. The present study investigated whether action co-representation depends on the perceived animacy of the non-biological interaction partner. Before performing a joint Simon task with either an animated image of a human or a wooden hand, participants either watched a video fragment of a biological agent, or of a non-biological agent, Pinocchio, to increase perceived animacy of this agent. Whereas participants who watched the 'biological' agent showed a Simon effect only when co-acting with a biological agent, participants who watched 'non-biological' agent (i.e. Pinocchio) showed a Simon effect only when co-acting with a non-biological agent. The present findings provide evidence for the assumption that motor simulation strongly depends on higher order processes.


Assuntos
Mãos/fisiologia , Comportamento Imitativo/fisiologia , Desempenho Psicomotor/fisiologia , Percepção Visual/fisiologia , Adulto , Feminino , Humanos , Movimento/fisiologia , Estimulação Luminosa/métodos , Tempo de Reação/fisiologia , Adulto Jovem
12.
J Cogn Neurosci ; 20(11): 2015-24, 2008 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-18416679

RESUMO

The present study attempts to explore the process by which knowledge of another's intentional behavior in a joint-action scenario is represented through the action observation and execution network-also known as the common coding system. Participants (n = 18) were instructed to perform the complementary social Simon task under the implemented belief of interaction with either an unseen human (biological agent) or a computer program, where in fact, all response sequences from either "partner" were generated by computer. Results provide behavioral and neurophysiological evidence (P3 and S-LRP) that the believed intentionality of another person's actions is sufficient to facilitate a strong-enough agency-dependent social Simon effect to modulate action planning and anticipation. We suggest that the co-representation of human action may be an evolved biologically tuned default of the human motor system.


Assuntos
Variação Contingente Negativa/fisiologia , Potenciais Evocados P300/fisiologia , Comportamento Imitativo/fisiologia , Percepção Social , Análise de Variância , Mapeamento Encefálico , Tomada de Decisões/fisiologia , Eletroencefalografia/métodos , Feminino , Humanos , Masculino , Reconhecimento Visual de Modelos , Estimulação Luminosa/métodos , Tempo de Reação/fisiologia , Adulto Jovem
13.
Psychol Sci ; 18(12): 1058-62, 2007 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-18031412

RESUMO

Corepresenting actions performed by conspecifics is essential to understanding their goals, inferring their mental states, and cooperating with them. It has recently been demonstrated that joint-action effects in a Simon task provide a good index for corepresentation. In the present study, we investigated whether corepresentation is restricted to biological agents or also occurs for nonbiological events. Participants performed a Simon task either with an image of a human hand or with a wooden analogue. The Simon-like effect emerged only when participants coacted with a biological agent. The lack of the joint-action effect when participants interacted with a wooden hand indicates that the human corepresentation system is biologically tuned.


Assuntos
Membros Artificiais , Mãos , Destreza Motora , Adulto , Feminino , Humanos , Masculino , Psicologia/estatística & dados numéricos , Desempenho Psicomotor , Percepção Visual
14.
Exp Brain Res ; 175(2): 353-62, 2006 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-16799815

RESUMO

Many of our actions are influenced by the social context. Traditional approach attributes the influence of the social context to arousal state changes in a socially promotive way. The ideomotor approach, which postulates common coding between perceived events and intended actions, uses a conceptual scheme of ideomotor compatibility to explain self-other interaction. In this study, we recorded reaction times (RTs) and event-related potentials in a Go/NoGo task with stimulus-response (S-R) compatibility arrangement to examine how the social context affects self-other interaction. Although the social facilitation theory predicted that RTs would be faster when acting together with audience rather than acting alone, the ideomotor theory predicted S-R compatibility effects only for the joint condition. The results revealed S-R compatibility on the RTs, lateralized readiness potential of the Go trials, and P3 of the NoGo trials in the joint condition, which were in line with the predictions of the ideomotor theory. Owing to the anticipation of other's actions, self and other's actions are internally and unintentionally coded at the representational level and their functional equivalency can be realized through a common coding framework between perception and action systems. Social facilitation theory was not supported, because we found no significant data differences depending on the setting.


Assuntos
Relações Interpessoais , Modelos Teóricos , Desempenho Psicomotor/fisiologia , Tempo de Reação/fisiologia , Percepção Social , Adulto , Análise de Variância , Comportamento de Escolha/fisiologia , Variação Contingente Negativa/fisiologia , Eletroencefalografia , Feminino , Humanos , Masculino , Testes Neuropsicológicos
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