Recognition of post-learning alteration of hippocampal ripples by convolutional neural network differs in the wild-type and AD mice.

Evidence indicates that sharp-wave ripples (SWRs) are primary network events supporting memory processes. However, some studies demonstrate that even after disruption of awake SWRs the animal can still learn spatial task or that SWRs may be not necessary to establish a cognitive map of the environment. Moreover, we have found recently that despite a deficit of sleep SWRs the APP/PS1 mice, a model of Alzheimer's disease, show undisturbed spatial reference memory. Searching for a learning-related alteration of SWRs that could account for the efficiency of memory in these mice we use convolutional neural networks (CNN) to discriminate pre- and post-learning 256 ms samples of LFP signals, containing individual SWRs. We found that the fraction of samples that were correctly recognized by CNN in majority of discrimination sessions was equal to ~ 50% in the wild-type (WT) and only 14% in APP/PS1 mice. Moreover, removing signals generated in a close vicinity of SWRs significantly diminished the number of such highly recognizable samples in the WT but not in APP/PS1 group. These results indicate that in WT animals a large subset of SWRs and signals generated in their proximity may contain learning-related information whereas such information seem to be limited in the AD mice.

Adaptive Tracking Control for Robots With an Interneural Computing Scheme.

Adaptive tracking control of mobile robots requires the ability to follow a trajectory generated by a moving target. The conventional analysis of adaptive tracking uses energy minimization to study the convergence and robustness of the tracking error when the mobile robot follows a desired trajectory. However, in the case that the moving target generates trajectories with uncertainties, a common Lyapunov-like function for energy minimization may be extremely difficult to determine. Here, to solve the adaptive tracking problem with uncertainties, we wish to implement an interneural computing scheme in the design of a mobile robot for behavior-based navigation. The behavior-based navigation adopts an adaptive plan of behavior patterns learning from the uncertainties of the environment. The characteristic feature of the interneural computing scheme is the use of neural path pruning with rewards and punishment interacting with the environment. On this basis, the mobile robot can be exploited to change its coupling weights in paths of neural connections systematically, which can then inhibit or enhance the effect of flow elimination in the dynamics of the evolutionary neural network. Such dynamical flow translation ultimately leads to robust sensory-to-motor transformations adapting to the uncertainties of the environment. A simulation result shows that the mobile robot with the interneural computing scheme can perform fault-tolerant behavior of tracking by maintaining suitable behavior patterns at high frequency levels.

Operator control of interneural computing machines.

A dynamic representation of neural population responses asserts that motor cortex is a flexible pattern generator sending rhythmic, oscillatory signals to generate multiphasic patterns of movement. This raises a question concerning the design and control of new computing machines that mimic the oscillatory patterns and multiphasic patterns seen in neural systems. To address this issue, we design an interneural computing machine (INCM) made of plastic random interneural connections. We develop a mechanical way to measure collective ensemble firing of neurons in INCM. Two sorts of plasticity operators are derived from the measure of synchronous neural activity and the measure of self-sustaining neural activity, respectively. Such plasticity operators conduct activity-dependent operation to modify the network structure of INCM. The activity-dependent operation meets the neurobiological perspective of Hebbian synaptic plasticity and displays the tendency toward circulation breaking aiming to control neural population dynamics. We call such operation operator control of INCM and develop a population analysis of operator control for measuring how well single neurons of INCM can produce rhythmic, oscillatory activity, but at the level of neural ensembles, generate multiphasic patterns of population responses.

Decirculation process in neural network dynamics.

We describe a decirculation process which marks perturbations of network structure and neural updating that are necessary for evolutionary neural networks to proceed from one circulating state to another. Two aspects of control parameters, screen updating and flow diagrams, are developed to quantify such perturbations, and hence to manage the dynamics of evolutionary neural networks. A dynamic state-shifting algorithm is derived from the decirculation process. This algorithm is used to build models of evolutionary content-addressable memory (ECAM) networks endowed with many dynamic relaxation processes. By the training of ECAM networks based on the dynamic state-shifting algorithm, we obtain the classification of training samples and the construction of recognition mappings, both of which perform adaptive computations essential to CAM.