Mechanical ventilation in a dog with acetylcholinesterase inhibitor toxicosis.

BACKGROUND: To describe a case of acetylcholinesterase inhibitor (AChEI) toxicosis with ventilatory failure that was successfully treated with mechanical ventilation (MV). KEY FINDINGS: A 7-year-old, female spayed German Short-haired Pointer, presented with acute onset ptyalism, generalized muscle tremors, and diarrhea. Physical examination findings included evidence of muscarinic overstimulation in the parasympathetic nervous system (eg, diarrhea, ptyalism, lacrimation), and nicotinic overstimulation in the sympathetic nervous system (tachycardia), central nervous system (agitation), and the neuromuscular junction (eg, diffuse muscle fasciculations, tetraparesis). Point-of-care testing demonstrated hyperlactatemic metabolic acidosis and respiratory acidosis (hypoventilation). Hypoventilation progressed to respiratory failure and the dog lost its gag reflex necessitating emergency endotracheal intubation and MV. Additional treatments included atropine, parenteral antimicrobials (for aspiration pneumonia), pralidoxime, and supportive care. Weaning from the ventilator was achieved in 4 days. The dog was administered supplemental oxygen for 24 hours, and discharged 48 hours later with improved neurologic function and normal respiratory drive. Whole blood acetylcholinesterase activities measured on day 0, 2, and 4 and were consistent with AChEI toxicity. NEW OR UNIQUE INFORMATION PROVIDED: Specific AChEI toxicity (ie, carbamate and organophosphate) has been reported in the veterinary literature with good prognosis for survival and hospital discharge. While the existing veterinary literature suggests that ventilatory failure is rare in this disease syndrome, consideration for treatment with MV must be made for patients that develop respiratory failure (associated with hypoventilation, bronchoconstriction, bronchorrhea, or aspiration pneumonia).

Evaluation of a training course in focused echocardiography for noncardiology house officers.

OBJECTIVE: To determine whether a training course in focused echocardiography can improve the proficiency of noncardiology house officers in accurately interpreting cardiovascular disease and echocardiography findings in dogs entering the emergency room setting. DESIGN: Prospective, blinded, educational study. SETTING: University veterinary teaching hospital. STUDY SUBJECTS: House officers underwent training in focused echocardiography. Fifteen dogs, including normal dogs and dogs with stable congenital or acquired cardiac disease, were used as study subjects during the laboratory session. INTERVENTIONS: A 6-hour curriculum on focused echocardiography was developed that included didactic lectures, clinical cases, and hands-on echocardiography. MEASUREMENTS AND MAIN RESULTS: Pre- and postcourse written examinations were administered to participants. House officers attended didactic lectures that were subsequently followed by a hands-on laboratory session and practical examination, which involved performing transthoracic echocardiography on dogs with and without cardiovascular disease. Twenty-one house officers completed the focused echocardiography training course. Written examination scores were 57 ± 12% before and 75 ± 10% after training (P < 0.001). Following the course, 97% of participants in the practical examination were able to obtain the correct right parasternal short- or long-axis view. Posttraining, most participants correctly identified pleural effusion (90%) and pericardial effusion (95%) and discriminated normal atrial size from atrial enlargement (86%). However, successful identification of a cardiac mass, volume status, and ability to recognize a poor quality study as nondiagnostic remained relatively low. Most trainees responded that the length of hands-on laboratory training was too abbreviated and that the course should be > 6 hours. CONCLUSION: A focused echocardiography training course improved knowledge and yielded acceptable proficiency in some echocardiographic findings commonly identified in the emergency room. This training course was not able to provide the skills needed for house officers to accurately assess fluid volume status, identify cardiac masses, ventricular enlargement or hypertrophy, and certain cardiac diseases.