RESUMO
To identify genetic alterations associated with tongue cancer recurrence in young adults, whole exome sequencing of the primary tumor, recurrence, and whole blood samples from young patients with tongue cancer was performed. A frameshift mutation in the TP53 gene was detected in the primary tumor and recurrence tumor tissue. A mutation in the EPHB6 gene was detected in the recurrence and was absent in the primary tumor. In addition, the primary tumor and recurrence tongue cancer tissue harbored amplification of the 20p13 region containing C20orf96, DEFB125, DEFB126, DEFB127, DEFB128, DEFB129, DEFB132, and ZCCHC3 genes. Thus, genetic alterations have been identified that are associated with tongue cancer recurrence in young adults.
Assuntos
Sequenciamento do Exoma , Recidiva Local de Neoplasia , Neoplasias da Língua , Proteína Supressora de Tumor p53 , Humanos , Neoplasias da Língua/genética , Neoplasias da Língua/patologia , Recidiva Local de Neoplasia/genética , Recidiva Local de Neoplasia/patologia , Proteína Supressora de Tumor p53/genética , Adulto Jovem , Masculino , Adulto , Feminino , Mutação da Fase de Leitura/genéticaRESUMO
The aim was to determine the different regiments of adjuvant therapy after radical surgery in patients with oral cancer based on the prognostic factors. 2-years disease-free survival in group with adjuvant chemoradiotherapy was 71.4%; in the adjuvant radiotherapy group - 66.2%. The neoadjuvant chemoradiotherapy demonstrated only 57% 2-years disease-free survival. Our results demonstrate that adjuvant radiotherapy or chemoradiotherapy combined with cisplatin is more effective in treatment of the patients with oral cancer.
Assuntos
Carcinoma de Células Escamosas/terapia , Quimiorradioterapia Adjuvante/métodos , Neoplasias Bucais/terapia , Terapia Neoadjuvante/métodos , Carcinoma de Células Escamosas/mortalidade , Carcinoma de Células Escamosas/patologia , Cisplatino/uso terapêutico , Intervalo Livre de Doença , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias Bucais/mortalidade , Neoplasias Bucais/patologia , Resultado do TratamentoRESUMO
The study included 159 patients with oral SCC in which metastatic patterns were evaluated after preventive lymphatic node dissection. Lymphatic node metastasis were found out in 24.5% of patients with the most common sites in subdigastrial (IIA) (69.2%) and submandibular (IB) (34.2%) and medium deep jugular (III) (28.2%) nodes. Involving of the IV level (lower deep jugular nodes) was noted in 5.2% of cases, both VA and VB - 2.6%. These results advocate preventive neck dissections in order to eliminate possible metastasis on all levels.
Assuntos
Carcinoma de Células Escamosas/patologia , Linfonodos/patologia , Linfonodos/cirurgia , Neoplasias Bucais/patologia , Feminino , Humanos , Excisão de Linfonodo , Metástase Linfática , Masculino , Estadiamento de NeoplasiasRESUMO
Examination of 220 patients was performed using ultrasound investigation (USI) in B-regimen, color and energy Doppler encoding, 3D-reconstruction of image and sonoelastography. There were 49 recurrences in the regional lymph nodes. Main semiotic signs of regional recurrences were identified. USI with the application of the methods described is highly informative: sensitivity--94.2%, specificity--92.5%, accuracy--91.7%.
Assuntos
Recidiva Local de Neoplasia/diagnóstico por imagem , Glândula Tireoide/diagnóstico por imagem , Neoplasias da Glândula Tireoide/diagnóstico por imagem , Ultrassonografia Doppler em Cores/métodos , Adulto , Idoso , Idoso de 80 Anos ou mais , Diagnóstico Diferencial , Feminino , Humanos , Imageamento Tridimensional , Linfonodos/diagnóstico por imagem , Linfonodos/patologia , Metástase Linfática , Masculino , Pessoa de Meia-Idade , Reprodutibilidade dos Testes , Sensibilidade e Especificidade , Glândula Tireoide/patologia , Neoplasias da Glândula Tireoide/secundário , Adulto JovemRESUMO
One hundred and seventy-two preventive neck dissections were performed in 159 oral SCC patients. The study revealed the possibility of skip metastases in the lower cervical lymphatic nodes thus confirming the necessity for their removal in elective neck dissections.