[Mechanisms of contractile action of acetylcholine on hepatic veins].

In acute experiments on anesthetized rats, acetylcholine (Ach) constricts hepatic venous vessels, causing blood mobilization from the liver, and dilates the sphincters of hepatic veins at the exit from this organ, contributing to the intensification of the outflow of blood deposited in the liver. Vasoconstrictor reactions of capacitive vessels of the liver to Ach are realized through M-cholinoreceptors on endotheliocytes with further involvement of messenger, possibly noradrenaline, which activates alpha-adrenoreceptors on smooth muscle cells (SMC) of capasitive vessels. Dilation of Hv sphincters is carried out due to Ach-induced release of messenger in the vessel wall, probably adrenaline, which in turn activates beta-adrenoreceptors on SMC of the Hv. It is possible, that in such reaction partially involved NO.

[Elucidation of the mechanisms of acetylcholine constrictor action on the portal vein and its intrahepatic branches].

Intraportal administration of acetylcholine (Ach) to anesthetized rats evokes endothelium depended, atropine resistant and phentholamine sensitive constriction of hepatic portal vessels. On the contrary to Ach action sodium nitroprussideresulted in vasodilatation in this vessel. On the isolated segment of portal vein (PV) similar results were obtained; at the same time the blockade of nicotinic acetylcholinic receptors by nicotine (in high concentration), tubocurarine or tetrodotoxine diminished constrictor reactions of PV to Ach. We concluded that described vasomotor effects of Ach in the hepatic portal bed are carried out through nicotinic Ach-receptors localized on endothelial cells and (or) adrenergic neurones in the wall of portal vessels. These cells synthesize and release mediators, possibly, noradrenaline which causes constriction of portal vessels.

[Interactions of human psycho-somato-visceral functions]. / Vzaiemozv'iazok psykhosomatovistseral'nykh funktsii liudyny.

Three typological groups (clusters) of human were picked out by complex of psycho-somato-visceral indexes. The most informaton and suitable for estimation indexes for dividing population of human into typological groups were established. Each group of persons is characterised by combination of properties that differ statistically from other groups. Some of this properties are genetic dependent.

[The regional hemodynamic characteristics of subjects with different types of blood circulation]. / Osoblyvosti rehionarnoï hemodynamiky u liudei z riznymy typamy krovobihu.

The group of 56 young healthy men was divided into three subgroups according to the cardiac output values: hypo-, eu- and hyperkinetic types of circulation. Regional hemodynamics was studied in the head, lungs and shin by means of rheoplethysmographic technique. It has been shown that pulse blood filling of the vessels of all the regions studied significantly depends on the type of circulation. In persons with hyperkinetic type of circulation the pulse blood filling was more expressed than in those with hypokinetic type. The analysis of the tone of large and middle vessels of the lungs and shin has demonstrated opposite relations. The tone of head vessels reveals no correlation with the types of circulation. This fact may be explained by existence of pronounced autoregulation of the brain circulation.