Discovery of olimycin E from Streptomyces sp. 11695.

A new natural product olimycin E (1), together with two known compounds of divergolide R (2) and olimycin B (3), were obtained from the marine-derived Streptomyces sp. 11695. The structures of 1-3 were established on the basis of HRESIMS as well as 1D and 2D NMR datasets. The absolute configuration of 1 is identified as 4 R, 6S, 7S, 10 R by comparison the experiment ECD with that of the theoretical ECD. Antibacterial results showed that compound 2 have antibacterial activities against Staphylococcus aureus and MRSA with the MIC values of 32 µg/mL, respectively.

Association between estimated glomerular filtration rate and reversion to normoglycemia in people with impaired fasting glucose: a 5-year retrospective cohort study.

OBJECTIVES: The present body of evidence regarding the correlation between the estimated glomerular filtration rate (eGFR) and the reversal of impaired fasting glucose (IFG) to normoglycemia remains constrained. Consequently, the objective of our study is to examine the relationship between eGFR and the restoration of normoglycemia in individuals with IFG. METHODS: This retrospective cohort study consecutively collected data from 24,541 non-selective participants with IFG at Rich Healthcare Group in China from January 2010 to 2016. We aimed to investigate the association between baseline eGFR and reversion to normoglycemia using the Cox proportional-hazards regression model. Through the utilization of a Cox proportional hazards regression model featuring cubical spline smoothing, we were able to ascertain the non-linear correlation between eGFR and the return to normoglycemia. Furthermore, various sensitivity and subgroup analyses were carried out, and a competing risk multivariate Cox regression was employed to examine the progression to diabetes as a competing risk for the reversal of normoglycemic events. RESULTS: In our study, comprising 24,541 participants, the average age was 49.25 ± 13.77 years, with 66.28% being male. The baseline eGFR mean was 104.16 ± 15.78 ml/min per 1.73 m2. During a median follow-up period of 2.89 years, we observed a reversion rate to normoglycemia of 45.50%. Upon controlling for covariates, our findings indicated a positive correlation between eGFR and the probability of returning to normoglycemia (HR = 1.008, 95% CI 1.006-1.009). In addition, a non-linear association was observed between eGFR and the likelihood of transitioning from IFG to normoglycemia. The inflection point of eGFR was found to be 111.962 ml/min per 1.73 m2, with HRs of 1.003 (95% CI 1.001, 1.005) on the left side of the point and 1.019 (95% CI 1.015, 1.022) on the right side. Our robust results were supported by competing risks multivariate Cox's regression and sensitivity analysis. CONCLUSIONS: The findings of our investigation indicate a favorable and non-linear correlation between eGFR and the restoration of normoglycemia in Chinese individuals with IFG. Specifically, a reduction in renal function at an early stage in these patients may considerably diminish the likelihood of attaining normoglycemia.

Correlations of cardiac function with inflammation, oxidative stress and anemia in patients with uremia.

The present study aimed to analyze the associations of cardiac function with inflammatory cytokines, oxidative stress and anemia in patients with uremia. A total of 79 patients with uremia were selected, and among those, 43 cases were complicated with cardiac dysfunction (observation group) and 36 patients were not (control group). The levels of inflammatory cytokines [C-reactive protein (CRP), interleukin-6 (IL-6) and IL-10], oxidative stress indicators [malondialdehyde (MDA), oxidized low-density lipoprotein (OX-LDL) and advanced oxidation protein products (AOPP)], blood routine parameters [hemoglobin (Hb), platelets (PLT), mean corpuscular volume (MCV)], and cardiac function [including cardiac output (CO), cardiac stroke volume (SV), left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEDd) and left ventricular end-systolic diameter (LVESd)] were measured. There were no statistically significant differences in age, sex, body mass index, total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol between the observation and the control group (P>0.05), but the observation group had significantly higher triglyceride levels and blood pressure, as well as longer duration of uremia compared with those in the control group (P<0.05). Furthermore, the levels of CRP, IL-6, IL-10, MDA, OX-LDL, AOPP, Hb, PLT and MCV in the observation group were significantly higher than those in the control group. In addition, regarding cardiac function, the observation group had a decreased CO, SV and LVEF and an increased LVEDd and LVESd compared with those in the control group. Furthermore, CRP (r=-0.636, P<0.01) and MDA (r=-0.705, P<0.01) were negatively correlated with LVEF, while Hb levels were positively correlated with LVEF (r=0.732, P<0.001). In conclusion, serum inflammatory cytokines, oxidative stress and the degree of anemia are associated with cardiac insufficiency in patients with uremia.