[Cytopenic syndromes in chronic hepatitis]. / Tsitopenicheskie sindromy pri khornicheskom gepatite.

The course of chronic hepatitis complicated by cytopenia has been analyzed for 31 patients. Clinical manifestations, early and differential diagnosis, treatment policy have been specified. It is advisable that such patients be observed both by hematologists and hepatologists.

[Morphocytochemical characteristics of hemopoietic cells in sideroblastic anemia]. / Morfotsitokhimicheskaia kharakteristika gemopoéticheskikh kletok pri sideroblastnoi anemii.

The findings of morphocytochemical and cytogenetic examinations of hemopoietic cells in 8 patients with sideroblastic anemia are analyzed. The authors consider that the final diagnosis of sideroblastic anemia can be made if the count of ring-shaped sideroblasts surpasses 30%. The leukemic nature of this condition is discussed.

[The comparative efficacy of splenectomy and antilymphocyte globulin therapy in patients with aplastic anemia]. / Sravnitel'naia éffektivnost' splenéktomii i terapii antilimfotsitarnym globulinom u bol'nykh aplasticheskoi anemiei.

Analysis of the clinical efficacy and long-term survival of patients with grave and not grave forms of aplastic anemia, subjected to splenectomy or treated with antilymphocytic globulin has shown that in grave aplastic anemia, the clinical efficacy of antilymphocytic globulin is higher than the efficacy of the operative treatment methods. The 30-month survival can be attained in 42% of the patients given globulin and in 28% of the patients after splenectomy. In patients with grave aplastic anemia, it is recommended that the treatment be instituted from the use of antilymphocytic globulin in a dose of 15 mg/kg bw daily for 5 days, provided there are no contraindications. In patients with not grave aplastic anemia, the results of splenectomy and therapy with antilymphocytic globulin are approximately the same: the 5-year survival amounts to 94 and 93%, respectively. Therefore, the use of globulin may be recommended as a method of choice for the above patients' group, since surgical approaches to the treatment are still coupled with a high risk for the patient's life.

[Clinical picture and diagnosis of refractory anemia with an excess of blasts and with bone marrow hypoplasia]. / Klinika i diagnostika refrakternoi anemii s izbytkom blastov i s gipoplaziei kostnogo mozga.

Clinical picture of refractory anemia with excessive blasts and bone marrow hypoplasia (RAEB with BMH) has been described in 22 patients. Statistically significant differences between RAEB with BMN and hypoplastic anemia have been presented. The problems of the differential diagnosis of RAEB with BMH have been discussed.

[Erythropoiesis inhibitor in the plasma of patients with hemopoietic dysplasias]. / Ingibitor éritropoéza v plazme bol'nykh s gipoplaziiami krovetvoreniia.

Altogether 21 patients were examined for an erythropoiesis inhibitor contained by the IgG fraction of the blood plasma. All these patients suffered from hemopoiesis depression. The inhibitor identified in the immunoglobulin fraction of the blood plasma of 40% of the patients manifested itself at the stage of erythroid precursors of bone marrow cells. The role of the humoral inhibitor in the development of erythropoietic disorders in these patients is under discussion.