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1.
Nutr Cancer ; 72(2): 194-201, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31259622

RESUMO

Purpose: Dysgeusia can be found in 50% of cancer patients undergoing chemotherapy. Nonetheless, dysgeusia can be present in treatment-naïve patients, and may negatively impact nutrition and quality of life.Methods: Treatment-naïve non-small cell lung cancer (NSCLC) was assessed for dysgeusia using a self-reporting questionnaire and a rinse stimuli technique. Patients were evaluated in terms of health-related quality of life (HRQL) using the EORTC-QLQ-C30 questionnaire and in terms of nutrition using the subjective global assessment (SGA), energy consumption and body composition.Results: Among 65 treatment-naïve patients, dysgeusia was self-reported in 35%. Using the rinse stimuli technique, most of the patients perceived taste stimuli with a minimal concentration, but could not recognize the taste. Patients with dysgeusia presented significantly less lean-body mass (P = 0.027), and higher fat mass (P = 0.027). Additionally, these patients had significantly more gastrointestinal symptoms including nausea (P = 0.042), anorexia (P = 0.004), and early satiety (P < 0.0001). Dysgeusia was also associated with less food consumption (P = 0.010). Last, patients with dysgeusia had clinically-significant alterations in HRQL scales.Conclusion: Presence of dysgeusia in NSCLC patients before undergoing chemotherapy is associated with worse nutritional outcomes. The routine assessment of dysgeusia in treatment-naïve patients should be encouraged to timely assess and follow nutritional parameters.


Assuntos
Carcinoma Pulmonar de Células não Pequenas/patologia , Disgeusia/epidemiologia , Neoplasias Pulmonares/patologia , Estado Nutricional , Qualidade de Vida , Anorexia/fisiopatologia , Feminino , Humanos , Incidência , Masculino , México/epidemiologia , Pessoa de Meia-Idade , Náusea/fisiopatologia , Autorrelato , Inquéritos e Questionários
2.
Nutr Cancer ; 71(3): 409-417, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30273069

RESUMO

Lung cancer (LC) has a high rate of anorexia, which negatively affects quality-of-life and prognosis; however prevalence values may vary as per diagnostic test. There is no standard for anorexia diagnosis, currently the anorexia cachexia scale (A/CS) has been proposed as a tool for diagnosing anorexia with a consensus cutoff value of ≤24, nonetheless a validated cutoff value is required. The A/CS was evaluated in advanced Non-Small Cell Lung Cancer (NSCLC) patients to establish a cutoff value. The appetite item from the QLQ-C30 questionnaire and survival served as a standard reference. The cutoff value was associated with clinical and nutritional characteristics along with quality-of-life. Three hundred and twelve (312) NSCLC patients were evaluated. The mean A/CS value was 31 ± 9 and the identified cutoff value was 32.5 (sensitivity: 80.3% and specificity: 85%). The proportion of anorexia accurately diagnosed with the cutoff value of 24 was 26%, while with 32 it was 50%. The A/CS cutoff value of 32 was associated with clinical parameters, nutritional consumption, and quality-of-life, and independently associated with overall survival. A score of ≤32 in the A/CS is proposed for anorexia diagnosis in order to identify patients at risk of complications involving malnutrition related to LC.


Assuntos
Anorexia/diagnóstico , Caquexia/diagnóstico , Carcinoma Pulmonar de Células não Pequenas/complicações , Neoplasias Pulmonares/complicações , Adenocarcinoma/complicações , Adenocarcinoma/tratamento farmacológico , Idoso , Anorexia/terapia , Apetite , Caquexia/terapia , Carcinoma Pulmonar de Células não Pequenas/tratamento farmacológico , Comportamento Alimentar , Feminino , Humanos , Neoplasias Pulmonares/tratamento farmacológico , Masculino , Pessoa de Meia-Idade , Qualidade de Vida , Valores de Referência , Inquéritos e Questionários
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