HETEROGENEITY OF CLINICAL MANIFESTATIONS OF HYPERPROLACTINEMIA (REVIEW AND OWN OBSERVATIONS).

The article is devoted to the features of the clinical picture of hyperprolactinemia, which can be partially determined by both gender and age of patients. Along with the well-known "classic" manifestations of hyperprolactinemiс syndrome, such as clinical signs of hypogonadism and mechanical pressure of the pituitary tumor on adjacent anatomical structures, there are others that are poorly known to a wide range of practicing physicians. Less frequent manifestations of hyperprolactinemia include the development of hypopituitarism, osteoporosis or osteopenia, alopecia. The analysis of literature data is illustrated with clinical examples from our own practice. It is noted that the pronounced heterogeneity of the clinical manifestations of hyperprolactinemia determines the need to develop continuity and consistency between doctors of different specialties for timely diagnosis and adequate treatment of this pathology.

[INFORMATIVITY ANALYSIS OF IMMUNOLOGIC MARKERS OF SLOWLY PROGRESSIVE AUTOIMMUNE DIABETES IN ADULTS (LADA)].

A survey of 116 patients with slowly progressive autoimmune diabetes of adults. (LADA) substantiates the need to define at least two kinds of antibodies for final verification of the diagnosis. It's been found that GAD ab and/or IA-2A ab are 'the most conclusive. Gender and age-specific rate of antibodies have been defined. In persons under 45 years ICA ab positive titer was detected significantly less frequently than in patients of middle age (45-59 years), a positive titer IA-2A ab detected more often in younger patients than in middle-aged persons. In women, the frequency of a positive titer ICA ab is significantly higher than that of men, but the incidence of positive titer IA-2A ab. is significantly higher in men than in women. The obtained data on the gender and age particularities of antibody in patients with LADA can be used while defining purposeful examination of the patients.