Rapidly Growing Chest Wall Lipoma: Case Report and Calculating Volume Doubling Time.

Chest wall lipoma is a rare disease that might be asymptomatic and discovered incidentally. Chest wall lipomas are presumed to grow slowly, but no reports have evaluated the tumor volume doubling time (TVDT). The present study herein reports the case of a 35-year-old female patient with a relatively fast-growing chest wall lipoma. Lipomas have their characteristic shape and grow very slowly, so they are rarely completely resected, even though they are monitored and repeated imaging studies are performed. Homogeneous very low density, clear margins, and no invasion to the surrounding structure are characteristic finding on imaging, but some patients without these characteristics here have been reported here. As there has been no report of TVDT for chest wall lipoma, comparison was not possible, but TDVT for lipoma in this patient ranged from 235-412 days. Compared with reports that patients with non-small cell lung cancer showed TVDT of less than 450 days, TVDT in the patient described here did not appear to be slow. Accumulation of knowledge about this rare disease will help to elucidate it further.

Atypical Remitting Seronegative Symmetrical Synovitis with Pitting Edema Syndrome in an Elderly Lung Cancer Patient.

Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome develops in patients with various underlying diseases. The involvement of vascular endothelial growth factor in the development of this syndrome has been suggested and malignant disease could be one of the underlying diseases of RS3PE syndrome. This syndrome is interpreted as one of the paraneoplastic syndromes that often have a poor prognosis. There have been few reports of lung cancer patients who developed RS3PE syndrome, and the prognosis of these patients has been rarely discussed. The present case report describes a very elderly lung cancer patient with RS3PE syndrome. We believe he is the oldest patient with advanced lung cancer to have developed RS3PE syndrome. Edema of the dorsum of both hands disappeared by one month after the start of first-line chemotherapy. The relatively long disease control period of the first and later lines of chemotherapy led to a long-term survival of 45 months. The existence of a patient with such a slow clinical course should be considered valuable for future research. It is important to continue optimal treatment even in elderly patients with RS3PE syndrome, one of the paraneoplastic syndromes.

Development of formaldehyde sensing element using porous glass impregnated with beta-diketone.

We have developed a sensor element for detecting formaldehyde. The sensor element is made of porous glass impregnated with both beta-diketone and ammonium ions. We used three kinds of beta-diketone; acetylacetone, 1-phenyl-1,3-butanedione, and 1,3-diphenyl-1,3-propanedione. The three kinds of sensor element, which are initially colorless, turn yellow after exposure to formaldehyde, and absorption with a peak wavelength of 407-424nm appears. There is a linear relationship between the 407-424nm absorbance of the sensor element after exposure to formaldehyde, and the formaldehyde concentration. The sensor element also works cumulatively, and the absorbance changes of the three kinds of sensor elements are acetylacetone>1-phenyl-1,3-butanedione>1,3-diphenyl-1,3-propanedione, when exposed to the same concentration of formaldehyde in the atmosphere. We also found that both the formation and decomposition reactions of lutidine derivative (yellow dye) occur on the acetylacetone element at 20 degrees C, and the kinetic constant of the former is 100,000 times larger than that of the latter. On the other hand, only the formation reaction occurs on the 1-phenyl-1,3-butanedione element at 20 degrees C. Therefore, the acetylacetone element would be suitable for short-term measurements and the 1-phenyl-1,3-butanedione would be suitable for long-term measurements.