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1.
Ir J Med Sci ; 185(1): 59-62, 2016 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-25359223

RESUMO

AIM: Airway changes, difficult ventilation, and intubation are the leading causes of morbidity and mortality in pregnancy, but no prospective study has evaluated the relationship between airway changes and brain natriuretic peptide (BNP) before and after cesarean section operations. The purpose of this study was to evaluate the relationship between BNP and airway changes in women undergoing delivery and during the postoperative period. MATERIALS AND METHODS: Included in this prospective study were a total of 35 pregnant females with ASA I physical status who were scheduled for cesarean section under general anesthesia. BNP levels, Mallampati classification, mouth opening, thyromental distance, sternomental distance, and the degree of neck extension were recorded before cesarean section and 24 h after the operation. Laryngeal views were also documented after intubation. RESULTS: Significant differences in BNP levels, Mallampati classification, mouth opening, thyromental distance, sternomental distance, and the degree of neck extension measurements arose between initial measurements and those measurements made 24 h postoperatively. Pre-delivery Mallampati I, II, III, IV scores of 6, 18, 7, 4 had by 24 h after cesarean section changed to 13, 13, 6, 3, respectively (p < 0.05). Initial BNP levels were 7.59 ± 6.30; postoperative levels were 52.39 ± 48.17. In this study we found a correlation between perioperative BNP levels and difficult intubation parameters. CONCLUSIONS: Within 24 h postpartum, Mallampati scores changed in 13 patients (30.95 %). Besides the correlation between BNP levels and difficult intubation parameters, we also found significant differences in initial and postoperative BNP values.


Assuntos
Cesárea/métodos , Intubação Intratraqueal/métodos , Peptídeo Natriurético Encefálico/metabolismo , Adulto , Anestesia Geral/métodos , Parto Obstétrico/métodos , Feminino , Humanos , Pescoço , Período Perioperatório , Gravidez , Estudos Prospectivos , Adulto Jovem
3.
Int J Tuberc Lung Dis ; 18(6): 671-5, 2014 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-24903937

RESUMO

BACKGROUND: The antimicrobial peptide cathelicidin LL-37/hCAP-18 and human ß-defensins (hBD) are key factors in innate immune responses of the respiratory tract. OBJECTIVE: To determine LL-37 and hBD-2 concentrations in the bronchoalveolar lavage (BAL) fluid of paediatric patients (aged <16 years) with pulmonary tuberculosis (TB) and to compare these with concentrations in healthy children. METHODS: We measured peptide concentrations using an immunosorbent assay (ELISA). RESULTS Forty TB patients and 40 healthy controls were enrolled in the study (mean age 9.2 ± 4.7 and 8.3 ± 4.2 years, respectively, P = 0.97). The two groups exhibited no statistically significant difference in terms of sex, body mass index, relative weight or 25-hydroxyvitamin D levels. The mean BAL LL-37 level of the TB group was significantly higher than that of the control group (0.95 ± standard deviation [SD] 1.33 vs. 0.35 ± SD 0.51 ng/ml, P = 0.01, t = 2.54). The hBD-2 level was also higher in the TB group; however, the difference was not statistically significant (0.30 ± SD 0.58 vs. 0.14 ± SD 0.30 ng/ml, P = 0.11). There was no correlation between LL-37, hBD-2 and 25-hydroxyvitamin D levels. CONCLUSIONS Our data suggest that LL-37 and hBD-2 may play an important role in TB pathogenesis in children. To our knowledge, this is the first study on BAL LL-37 and hBD-2 concentrations in children with pulmonary TB.


Assuntos
Líquido da Lavagem Broncoalveolar/química , Catelicidinas/análise , Imunidade Inata , Tuberculose Pulmonar/metabolismo , beta-Defensinas/análise , Adolescente , Fatores Etários , Peptídeos Catiônicos Antimicrobianos , Biomarcadores/análise , Líquido da Lavagem Broncoalveolar/imunologia , Líquido da Lavagem Broncoalveolar/microbiologia , Estudos de Casos e Controles , Criança , Pré-Escolar , Ensaio de Imunoadsorção Enzimática , Feminino , Humanos , Lactente , Masculino , Valor Preditivo dos Testes , Tuberculose Pulmonar/imunologia , Tuberculose Pulmonar/microbiologia , Regulação para Cima
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