RESUMO
AIMS: Currently available therapies do improve survival in advanced stage non-small cell lung cancer (NSCLC), but only to a limited degree. Talabostat mesilate (PT-100) is an orally available amino boronic dipeptide that specifically inhibits dipeptidyl peptidases (including fibroblast activation protein) and enhances an immune response. The aim of this study was to determine the efficacy and safety of talabostat in NSCLC patients. MATERIALS AND METHODS: A phase II trial was conducted to evaluate talabostat in combination with docetaxel in patients with advanced NSCLC after failure of previous platinum-based chemotherapy. In total, 42 patients were enrolled. RESULTS: Talabostat was well tolerated. Two patients achieved a partial response and one achieved a complete response. CONCLUSION: There was no evidence that talabostat enhanced the clinical activity of docetaxel in patients with NSCLC.
Assuntos
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Carcinoma Pulmonar de Células não Pequenas/tratamento farmacológico , Neoplasias Pulmonares/tratamento farmacológico , Adulto , Idoso , Idoso de 80 Anos ou mais , Ácidos Borônicos/administração & dosagem , Ácidos Borônicos/efeitos adversos , Carcinoma Pulmonar de Células não Pequenas/patologia , Dipeptídeos/administração & dosagem , Dipeptídeos/efeitos adversos , Docetaxel , Humanos , Neoplasias Pulmonares/patologia , Pessoa de Meia-Idade , Taxoides/administração & dosagem , Taxoides/efeitos adversosRESUMO
Amid divided opinion among professionals about the effect of nutrition on the outcome of pregnancy, one indisputable fact which emerges is that a good diet is essential during pregnancy and lactation. The role of the midwife in counseling and educating pregnant women on their own and their babies' nutritional need is discussed.
PIP: Despite the existence of numerous and conflicting schools of thought on the effect of nutrition of the course and outcome of pregnancy, it is generally accepted that nutrition is 1 of several socioeconomic factors influencing birth weight. The balanced diet of the mother during pregnancy should provide for an average physiologic weight gain of 12.5 kg. Dietary advice to the mother should include warnings against such agents as cigarettes, alcohol and drugs, which have a significant influence on dietary intake and its assimilation and can have detrimental effects on both mother and fetus. The nutritional needs of the infant in the first 4-6 months can best be met with breast milk. The midwife is in a unique position to encourage healthy physical and mental development by stressing the importance of sound dietary habits. To enable the midwife to fulfill this preventive role, she must be adequately prepared to give accurate and consistent dietary advice and must recognize her potential in this aspect of health education. The midwife training program needs to include adequate study of nutrition and be updated as necessary to consider advances in nutritional knowledge.