[Late thyroid and pancreas metastases from a clear cell renal carcinoma. Report of two cases]. / Metástasis tardias en tiroides y páncreas de carcinoma renal de células claras. Presentación de dos casos.

OBJECTIVE: To report two cases of late metastases of clear cell renal cell carcinoma. METHODS: Two patients, a male and a female with history of nephrectomy 17 and 16 years before for renal cell carcinomas, presented new tumours in the thyroid and pancreas, which were excised. RESULTS: Pathology reported that both lesions were clear cell tumours and immunohistochemically they were consistent with metastases from clear renal cell carcinomas. CONCLUSIONS: 1) Previous history of any type of carcinoma should suggest the possibility of metastases when facing a thyroid or pancreatic nodule. 2) All-life follow-up should be made, nephrectomy (resection) for a renal cell carcinoma. 3) In the presence of a clear cell tumour of the thyroid or pan-creatic glands, the differential diagnosis must always include metastatic renal cell carcinoma. 4) The treatment of choice is surgical resection.

Metástasis tardías en tiroides y páncreas de carcinoma renal de células claras. Presentación de dos casos / Late thyroid and pancreas metastases from a clear cel renal carcinoma. Report of two cases

Objetivo: Comunicar dos casos de metástasis tardías de carcinoma renal de células claras. Métodos: Dos pacientes, hombre y mujer, con historia de nefrectomía previa hacía 17 y 16 años respectivamente, presentaron nuevos tumores en tiroides y páncreas, que se extirparon. Resultados: La histopatología de ambas lesiones correspondió a tumores de células claras y el estudio inmunohistoquímico fue compatible con metástasis de carcinoma renal de células claras. Conclusiones: 1º) Ante nódulos en tiroides o páncreas, en pacientes con historia previa de cualquier tipo de carcinoma, se debe considerar la posibilidad de una metástasis. 2º) Los pacientes con carcinoma renal de células claras y nefrectomía (resección), deben tener un seguimiento de por vida, con una actitud de alerta a la aparición de nódulos en tiroides o en páncreas. 3º) En presencia de un tumor de células claras en tiroides o en páncreas, se debe incluir la posibilidad de un carcinoma renal metastático en el diagnóstico diferencial. 4º) El tratamiento de elección es la resección quirúrgica (AU)

Objective: To report two cases of late metastases of clear cell renal cell carcinoma. Methods: Two patients, a male and a female with history of nephrectomy 17 and 16 years before for renal cell carcinomas, presented new tumours in the thyroid and pancreas, which were excised. Results: Pathology reported that both lesions were clear cell tumours and immunohistochemically they were consistent with metastases from clear renal cell carcinomas. Conclusions: 1º) Previous history of any type of carcinoma should suggest the possibility of metastases when facing a thyroid or pancreatic nodule. 2) All-life follow-up should be made, nephrectomy (resection) for a renal cell carcinoma. 3) In the presence of a clear cell tumour of the thyroid or pancreatic glands, the differential diagnosis must always include metastatic renal cell carcinoma. 4) The treatmet of choice is surgical resection (AU)

Metaplasia ósea en dermatofibroma cutáneo / Osseous metaplasia in cutaneous dermatofibroma

Distintos tipos histológicos de dermatofibromas cutáneos han sido descritos. En la literatura, solo hemos encontrado publicado un caso con metaplasmaósea. Presentamos un dermatofibroma cutáneo osificante, con las peculiaridades clínicas de ser mayor de 1 cm, ser doloroso y aparecer inicialmenteen un varón joven

Different types of cutaneous dermatofibromas have been described. In the literature, we have only found one case with osseous metaplasia. We presentan ossifying cutaneous dermatofibroma with the clinical peculiarities of a size bigger than 1 cm, being very painful and it appearance initially in ayoung male

[Squamous carcinoma of the penis with a rhabdoid phenotype]. / Carcinoma escamoso de pene con fenotipo rabdoide.

OBJECTIVE: To describe a squamous cell carcinoma of the penis with rhabdoid phenotype. We believe that only three squamous cell carcinomas with rhabdoid cells have been previously published and none of them was located in the penis. METHODS AND RESULTS: A 76 year old man presented a tumoral lesión in his penis, which had all the light microscopic and immunohistochemical features of a squamous cell carcinoma with rhabdoid phenotype. Rhabdoid cells were mainly located in areas with an alveolar pattern, most of them being isolated and intermixed with necrotic cells and necrotic debris. CONCLUSIONS: First case of rhabdoid squamous cell carcinoma located in the penis. We suggest that rhabdoid phenotype could represent a type of degeneration, or a preliminary stage before apoptosis or cell necrosis occurs, instead of a specific differentiation. The most important prognostic factors in extrarenal tumors with rhabdoid features are stage and histologic type of tumors.

Carcinoma escamoso de pene con fenotipo rabdoide / Penile squamous cell carcinoma with rhabdoid phenotype

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Squamous cell carcinoma of the penis with rhabdoid features.

A 76-year-old man presented with a tumoral lesion in his penis that had all the light microscopic and immunohistochemical features of a squamous cell carcinoma with rhabdoid phenotype. We believe that this is the fourth reported case of squamous cell carcinoma with rhabdoid features and the first one located in the penis. Rhabdoid cells were primarily located in areas with an alveolar pattern, most of them being isolated and intermixed with necrotic cells and necrotic debris. We suggest that the rhabdoid phenotype could represent a type of degeneration, or a preliminary stage before apoptosis or cell necrosis, instead of a specific differentiation. In extrarenal tumors with rhabdoid features, stage and histologic types of tumors where rhabdoid changes occur are the most important prognostic factors.