Metástasis en ganglios axilares no centinelas asociada con micrometástasis en ganglio centinela en pacientes con cáncer de mama invasivo / No disponible

Objetivos: Determinar la frecuencia de metástasis en ganglios no centinelas en pacientes con micrometástasis en ganglio centinela e identificar factores predictivos de metástasis en ganglios no centinelas. Material y métodos: Estudio retrospectivo de pacientes diagnosticadas de carcinoma infiltrante de mama en las que se realizó linfadenectomía axilar por micrometástasis en ganglio centinela. Se estudiaron características clínicas (edad, tamaño tumoral clínico, estadio clínico, quimioterapia neoadyuvante) e histopatológicas (tamaño tumoral patológico, tipo histológico, grado histológico, receptores hormonales, Herceptest® e invasión linfovascular). Se estudió la relación entre la afectación tumoral de ganglios no centinelas y las variables estudiadas. Resultados: En 18 pacientes se practicó linfadenectomía axilar por micrometástasis en ganglio centinela. Cuatro (22%) presentaron metástasis en ganglios no centinelas. Tras la linfadenectomía, la clasificación ganglionar pasó de pN1(mic)gc a pN1a en dos casos, a pN2a en un caso y en otra paciente se mantuvo pN1(mic). El análisis bivariante no encontró relación entre la afectación tumoral de ganglios no centinelas y las características clínicas e histopatológicas. Conclusiones: La linfadenectomía cambió la estadificación de los ganglios axilares en el 17% de los casos. No se encontró relación entre la afectación de ganglios no centinelas y las características clínicas e histopatológicas(AU)

Aims: To determine the frequency of metastases in nonsentinel lymph nodes of patients with sentinel lymph node micrometastases and to identify predictive factors for metastatic disease in non sentinel nodes from infiltrating breast cancer patients. Material and methods: A set of patients with infiltrating breast cancer and micrometastases in sentinel lymph node biopsy was retrospectively followed-up. Clinical (age, tumor size, clinical stage, neoadjuvant therapy) and histopathological (pathological tumor size, histologic type and grade, hormone receptor and HER-2 status and lymph-vascular invasion) were recorded as well as metastases size. The relationship between these factors was studied. Results: Axillary lymphadenectomy was performed in 18 cases with sentinel lymph node micrometastases and metastases were identified in 4 (22%) of them. Node staging shifted from pN1(mic)sn to pN1a in two cases, to pN2a in one, and not modified in one case. Bivariant analysis did not find relationship between tumoral afectation of non sentinel lymph nodes and clinical and pathological features. Conclusion: In our sample lymphadenectomy changed node staging in 17% of the cases. No relationship between clinicopathological features and non sentinel node afectation was found(AU)

[Anisakiasis at the ileal level]. / Anisakiasis a nivel ileal.

Two cases of ileal anisakiasis are presented here. Symptoms were compatible with appendicitis. Either of them were operated on, the both were found and ileal tumour. Damage zone was removed. Pathological examination of piece showed us anisakis simplex larva set in the mucosa. The evolution of patients had no complications, currently they are asymptomatic. Both of them had eaten uncooked anchovy some days before. Anisakiasis cases are quite strange in Spain. There was only seven cases of anisakiasis in Spanish literature previously.