Parents' Beliefs about Medicines and Their Influence on Inhaled Corticosteroid Adherence in Children with Asthma.

The most widespread chronic condition observed amid children globally is asthma. Only half of children with asthma adhere to their prescribed inhaled corticosteroids (ICS) therapy. Parents' emotions and perspectives regarding asthma have an impact on inhalation corticosteroid adherence. The participants in this study were 148 parents of children with asthma, with the aim to redintegrate their beliefs about medicines in general and specifically of ICS and the impact on ICS adherence in children with asthma. Children were mostly male (66.9%), older than five years (58.8%), parents were female, mean age 38, employed, and with a history of consumption of some form of corticosteroids. Parents' answers show that 50% of them disagreed with the statement that medicines are addictive, and 90% agree that medicine helps many to live better. A percentage of 77.7% of parents acknowledge that their child's health relies on inhaled corticosteroids (ICS), and 86.5% of parents agree that these medications safeguard their child from worsening health. Most of the parents (93.2%) adhere to the guidelines and instructions of the doctor. In summary, parents who hold the belief that medicines are neither overused nor harmful tend to exhibit a higher adherence. Furthermore, those with elevated adherence levels express lower levels of concern regarding the use of inhaled corticosteroids (ICS) in their children's asthma therapy.

Perception of Illness and Fear of Inhaled Corticosteroid Use among Parents of Children with Asthma.

The most prevalent children's chronic disease worldwide is asthma which has notable negative impacts on patients' and parent's quality of life. Daily inhaled corticosteroids (ICS) therapy is a preferred controller choice. This study was conducted on 148 parents of asthmatic children to establish parents' perception of illness and fear of inhaled corticosteroids using B-IPQ and TOPICOP questionnaires. Children were in the majority male (66.9%), older than five years (58.8%), with comorbidities, and family history of atopy. Parents were female, with a mean age of 38, employed, and with a history of some form of corticosteroid use. Most parents were not afraid of ICS usage (71.6%). Unemployed parents and parents who had no medical education had a statistically significantly higher fear of using ICS (p = 0.002, p = 0.03). A child's illness affects the parents' lives and parents who are afraid of using ICS react more emotionally to the child's illness. Better understanding and less concerned about child's disease are parents of children with controlled asthma. The parents' perspective of children's asthma will affect the duration and dose of ICS treatment they will give to their children and directly influence the level of asthma control.

Sleep EEG composition in the first three months of life in monozygotic and dizygotic twins.

We investigated genetic influence on sleep electroencephalogram (EEG) composition by a classical twin study of monozygotic (MZ) and dizygotic (DZ) twins in the first 3 months of life. Polysomnographic (PSG) recordings were obtained in 10 MZ and 20 DZ twin pairs in the 37th, 46th, and 52nd week of postmenstrual age (PMA). The EEG power spectra were generated on the basis of fast Fourier transformation (FFT). Genetic influence on active sleep/rapid eye movement (AS/REM)] and quiet sleep/non rapid eye movement (QS/NREM) sleep composition was estimated by calculating within pair concordance and the intraclass correlation coefficients (ICCs) for delta (0.5-3.5 Hz), theta (4-7.5 Hz), alpha (8-11.5 Hz), sigma (12-14 Hz), and beta (14.5-20 Hz) at central derivation. MZ twins show higher ICCs than DZ twins for alpha, sigma, and beta spectral powers during QS/NREM sleep in the 37th, 46th, and 52nd week PMA. However, there was no significant difference (P > .05) between the 2 types of twins in absolute differences of EEG spectral power of the alpha, beta, and sigma frequency ranges in the 37th, 46th, and 52nd week PMA. The greatest mean absolute difference within MZ and DZ twin pairs and also between MZ and DZ twin groups was identified in the delta frequency range. Our findings gave an indication of genetic influence on alpha, sigma, and beta frequency ranges in the QS/NREM sleep stage.

EEG polysomnographic study of maturational differences between twins.

The purpose of this pilot study is to asses the effects of multiple pregnancies on the maturation of the developing brain using the polysomnographic EEG recordings. Data from prospectively recorded 10 twin sets, born prematurely (mean 36 gestational week; range 33 - 38 GW) in the Split University Hospital Center, were analysed. We compared sleep architecture parameters in the twins at 37h and 44th postmenstrual age (PMA) with parameters that were expected at that PMA. The same parameters were compared within each twin pair using the Man Whitne test. At first measurement indeterminate sleep (IS) proportion was greater in the first twin than in the second one. The IS sleep proportion was 1.6 fold greater in the first twin (p=0.028), and 1,8 fold less percentage of quite sleep (QS) than the second twin (p=0.054). The length of sleep stages among the twins was similar at the second measurement. Measures of sleep architecture were not significantly different within the twins in second recording. The results of this study obtained on a relatively small number of twins (longer IS and shorter QS in the first twin at the 38th week recordings), showed that the maturational differences among twins exist in utero and shortly after birth, and then disappear until the end of the first month of the postnatal life.

Attitudes towards science and alternative medicine of medical, economics and business, and electrical engineering students in Split, Croatia.

AIM: To assess attitudes of students at the Split University Schools of Medicine, Economics and Business, and Electrical Engineering towards science and alternative medicine. METHODS: There were 275 respondents surveyed for their opinion on science and different aspects of alternative medicine. The respondents were grouped into three major groups: medical students (83 or 30%), economics and business students (95 or 35%), and electrical engineering students (97 or 35%). Each group was composed of two subgroups: first and final year students. We used a specially designed questionnaire composed of four parts to collect students' demographic data and investigate their scientific experience and attitudes towards science and alternative medicine. ANOVA was used to test the differences among the three major groups of students and between first and final year students within each group. RESULTS: There was no significant difference among the first year students at three different schools in their scores on attitude towards science (ANOVA; F=0.001, p=0.99) and the attitude towards alternative medicine (F=2.61, p=0.08). However, there was a significant difference among the final year students at the three schools, with medical students being the most positive in their score on the attitude towards science (F=7.30, p=0.001) and least positive in their score on the attitude towards alternative medicine (F=30.7, p<0.001). There was a negative correlation between attitudes towards science and alternative medicine (r=-0.37, p<0.001) for all schools. CONCLUSION: Medical students showed the most positive attitude towards science and least positive attitude towards alternative medicine, compared with the students of economics and business or electrical engineering. The curriculum of the Medical School, unlike the curricula of other two schools, could have an impact on students' attitudes towards science.